- Dissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport
2026/03/19 by Nina Kim Stoffel, Srimeenakshi Sankaranarayanan, Kira Müntjes +4 · 2 voices
Biochemistry, Genetics and Molecular Biology · #Binding site #Endosome #Function (biology) #Messenger RNA #Nuclear Structure and Function #Plasma protein binding #RNA #RNA Research and Splicing #RNA modifications and cancer #RNA-binding protein #Regulon #Transport protein
- A near-complete map of human cytosolic degrons and their relevance for disease
2026/02/06 by Vasileios Voutsinos, Kristoffer E. Johansson, Fia B. Larsen +8 · 1 voice · 5 citations
Biochemistry, Genetics and Molecular Biology · #Binding site #Cell death mechanisms and regulation #Cricetulus #Cytosol #Degron #Plasma protein binding #Proteasome #Protein Data Bank (RCSB PDB) #Protein Degradation and Inhibitors #Protein degradation #Proteolysis #Ubiquitin #Ubiquitin and proteasome pathways
- The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb
2026/01/16 by Ying Zhang, Lorenz Grundmann, Leonie Vollmar +9 · 2 voices
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #ATP hydrolysis #Binding site #Folding (DSP implementation) #Function (biology) #Heat shock proteins research #Plasma protein binding #RNA and protein synthesis mechanisms #Ribosomal protein #Ribosome #Saccharomyces cerevisiae #Toxin Mechanisms and Immunotoxins #Translation (biology) #Yeast
- Crystallographic and EPR-based characterisation of Cu 2+ -binding to serum albumin: ATCUN coordination and additional sites
2026/01/01 by Michal Gucwa, K.B. Handing, Vanessa Amanda Bijak +10 · 3 voices
Biochemistry, Genetics and Molecular Biology · Medicine · Nursing · #Albumin #Binding site #Copper #Homeostasis #Metal complexes synthesis and properties #Plasma protein binding #Protein Interaction Studies and Fluorescence Analysis #Serum albumin #Trace Elements in Health
- Phage nuclease-mediated defense activation of the bacterial Retron-Eco7 toxin–antitoxin system
2025/11/13 by Zhikang Dai, Chang Liu, Yanjing Wang +9 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Bacillus and Francisella bacterial research #Bacterial Genetics and Biotechnology #Bacteriophages and microbial interactions #Binding site #DNA #Effector #Endonuclease #Phage display #Plasma protein binding #RNA #RNA-Directed DNA Polymerase #Reverse transcriptase
- Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
2025/10/15 by Piotr Drączkowski, Szu-Ni Chen, Ting Chen +10 · 1 voice · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Binding site #Mechanism (biology) #Peptidase Inhibition and Analysis #Plasma protein binding #Proteasome #Protein–protein interaction #RNA modifications and cancer #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase #Ubiquitin-Protein Ligases #Ubiquitins
- Photoaffinity Labeling Reveals a Role for the Unusual Triply Acylated Phospholipid N -Acylphosphatidylethanolamine in Lactate Homeostasis
2025/09/05 by Din-Chi Chiu, Yuan‐Ting Cho, Hening Lin +1 · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Binding site #Biochemistry #Biophysics #Cannabis and Cannabinoid Research #Cell biology #Chemistry #Homeostasis #Lipid Membrane Structure and Behavior #Membrane #Pancreatic function and diabetes #Phospholipid #Photoaffinity labeling #Stereochemistry
- Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis
2024/09/11 by Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp · 3 voices
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #ATPase #Bacillus subtilis #Bacterial Genetics and Biotechnology #Binding site #Cell division #Cell membrane #Escherichia coli #Membrane #Membrane protein #RNA and protein synthesis mechanisms
- Gating and modulation of an inward-rectifier potassium channel
2022/12/16 by Vishwanath Jogini, Morten Ø. Jensen, David E. Shaw · 9 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Binding site #Biochemistry #Biology #Biophysics #Cardiac electrophysiology and arrhythmias #Chemistry #Crystallography #Gating #Inward-rectifier potassium ion channel #Ion channel #Ion channel regulation and function #KcsA potassium channel #Ligand-gated ion channel #Neuroscience and Neuropharmacology Research #Potassium channel #Receptor #Spermine
- The Disordered MAX N-terminus Modulates DNA Binding of the Transcription Factor MYC:MAX
2022/09/26 by Stefan Schütz, Christian Bergsdorf, Benedikt Goretzki +4 · 14 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #B3 domain #Binding domain #Binding site #Biochemistry #Biology #Biophysics #Chemistry #DNA #DNA binding site #DNA-binding domain #DNA-binding protein #Gene #Gene expression #HMG-box #Intrinsically disordered proteins #Monoclonal and Polyclonal Antibodies Research #Nuclear magnetic resonance spectroscopy #Peptidase Inhibition and Analysis #Promoter #Protein Degradation and Inhibitors #Stereochemistry #Transcription factor
- NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2
2022/01/08 by Heidi Erlandsen, Anne M. Jecrois, Jeffry C. Nichols +2 · 8 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Binding site #Biochemistry #Biology #Biophysics #Chemistry #Cofactor #Dimer #Dissociation constant #Enzyme #Gene #Isothermal titration calorimetry #Kruppel-like factors research #Microbial metabolism and enzyme function #NAD+ kinase #Nucleotide #Plasma protein binding #RNA modifications and cancer #Receptor #Stereochemistry #Tetramer
- TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
2021/08/10 by Martina Hallegger, Anob M. Chakrabarti, Flora Lee +14 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #RNA Research and Splicing #Amyotrophic Lateral Sclerosis Research #Neurogenetic and Muscular Disorders Research #Biology #RNA #RNA-binding protein #Cell biology #Context (archaeology) #Plasma protein binding #Binding site #Transcriptome #Gene #Biophysics #Gene expression #Genetics
- CLIP and complementary methods
2021/03/04 by Markus Hafner, Maria Katsantoni, Tino Köster +5 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Binding site #Biology #Computational biology #Computer science #Gene #Genetics #Immunoprecipitation #RNA #RNA Research and Splicing #RNA and protein synthesis mechanisms #RNA modifications and cancer #RNA-binding protein #Ribonucleoprotein
- Mechanics of allostery: contrasting the induced fit and population shift scenarios
2019/06/30 by Riccardo Ravasio, Solange Marie Flatt, Solange Flatt +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Mathematics · Physics and Astronomy · #Allosteric enzyme #Allosteric regulation #Binding site #Biology #Biophysics #Chemistry #Consistency (knowledge bases) #Cooperative binding #Cooperativity #Enzyme Structure and Function #Evolutionary biology #Function (biology) #Geometry #Hemoglobin structure and function #Mathematics #Physics #Population #Protein Structure and Dynamics #Receptor #Statistical physics #Stiffness #Thermodynamics #cond-mat.soft #physics.bio-ph
- Insights into the Cooperative Nature of ATP Hydrolysis in Actin Filaments
2018/09/01 by Harshwardhan H. Katkar, Aram Davtyan, Aleksander E. P. Durumeric +5 · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Materials Science · #ATP hydrolysis #ATPase #Actin #Adhesion, Friction, and Surface Interactions #Binding site #Biochemistry #Biology #Biophysics #Cellular Mechanics and Interactions #Chemical physics #Chemistry #Cooperative binding #Cooperativity #Crystallography #Granularity #Kinetics #Material Dynamics and Properties #Nucleotide #Physics #Protein filament
- The cytochrome bc complex inhibitor Ametoctradin has an unusual binding mode
2018/04/25 by Adalbert Dreinert, Antje Wolf, Tobias Mentzel +2 · 7 citations
Agricultural and Biological Sciences · Chemistry · #Binding site #Biochemistry #Biology #Chemistry #Coenzyme Q – cytochrome c reductase #Cytochrome #Cytochrome P450 reductase #Cytochrome b #Cytochrome c #Enzyme #Fungal Plant Pathogen Control #Gene #Mitochondrial DNA #Mitochondrion #Plant Pathogens and Resistance #Plant-Microbe Interactions and Immunity #Stereochemistry #Ubiquinol
- Global RNA recognition patterns of post‐transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo
2016/04/04 by Erik Holmqvist, Patrick R. Wright, Lei Li +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · #RNA and protein synthesis mechanisms #Bacterial Genetics and Biotechnology #Bacteriophages and microbial interactions #Biology #RNA #RNA-binding protein #Transcriptome #Transfer RNA #Gene #Genetics #Messenger RNA #Binding site #Post-transcriptional regulation #Regulation of gene expression #Computational biology #Cell biology #Gene expression
- Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
2016/03/31 by Iván M. Lengyel, Luis G. Morelli · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Physics and Astronomy · #Autoregulation #Bacterial Genetics and Biotechnology #Binding site #Biology #Bursting #Cell biology #DNA binding site #Gene #Gene Regulatory Network Analysis #Gene expression #Genetics #Neuroscience #Promoter #Psychological repression #RNA Research and Splicing #Repressor #Transcription (linguistics) #Transcription factor #physics.bio-ph #q-bio.MN
- Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
2016/03/28 by Eric L Van Nostrand, Eric L. Van Nostrand, Gabriel A Pratt +18 · 7 citations
Biochemistry, Genetics and Molecular Biology · #Binding site #Biology #Computational biology #Gene #Gene expression #Genetics #Immunoprecipitation #RNA #RNA Research and Splicing #RNA and protein synthesis mechanisms #RNA modifications and cancer #RNA-binding protein #Ribonucleoprotein #Transcriptome
- Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)
2015/08/28 by Wu He, Bin Zhou, Weijia Liu +16 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Binding site #Biochemistry #Biology #Cancer-related molecular mechanisms research #Chemistry #Endocrinology #Fat mass #Identification (biology) #Obesity #Pharmacology #Plasma protein binding #RNA Research and Splicing #RNA modifications and cancer #Small molecule
- Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
2014/03/19 by Brendan J. Hilbert, Steven R. Grossman, Celia A. Schiffer +1 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Active site #Binding site #Biochemistry #Biology #Cancer-related gene regulation #Cell biology #Chemistry #Dehydrogenase #Enzyme #Genetic Syndromes and Imprinting #Hydrolase #Kruppel-like factors research #NAD+ kinase #Stereochemistry #Substrate (aquarium)
- Structural and Functional Analysis of Human SIRT1
2013/10/10 by Andrew M. Davenport, Ferdinand M. Huber, Ferdinand Huber +1 · 28 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Binding site #Biochemistry #Biology #Biophysics #Calcium signaling and nucleotide metabolism #Chemistry #Cofactor #Enzyme #Gene #NAD+ kinase #Plasma protein binding #Protein structure #Sirtuin #Sirtuin 1 #Sirtuins and Resveratrol in Medicine #Stereochemistry #Toxin Mechanisms and Immunotoxins
- Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Novel Compounds
2013/09/05 by Cameron S. Brand, Harrison J. Hocker, Alemayehu A. Gorfe +3 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Adenylyl cyclase #Allosteric regulation #Amino acid #Binding site #Biochemistry #Chemistry #Enzyme #Forskolin #Gene #Gene isoform #Phosphodiesterase function and regulation #Protein Kinase Regulation and GTPase Signaling #Receptor #Receptor Mechanisms and Signaling #Transmembrane protein
- Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites
2012/07/02 by Gregory R. Bowman, Phillip L. Geissler · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Protein Structure and Dynamics #RNA and protein synthesis mechanisms #Bacterial Genetics and Biotechnology #Allosteric regulation #Ligand (biochemistry) #Allosteric enzyme #Computational biology #Drug discovery #RNase P #Protein dynamics #Binding site #Docking (animal) #Biology #Protein structure #Chemistry #Bioinformatics #Genetics #Biochemistry #RNA #Receptor
- DNA Binding Regulates the Self-Association of the ETS Domain of PU.1 in a Sequence-Dependent Manner
2012/04/26 by Gregory M. K. Poon, Gregory M.K. Poon · 9 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Binding site #Biochemistry #Biology #Biophysics #Chemistry #Cooperative binding #Cooperativity #Crystallography #DNA #DNA Repair Mechanisms #DNA and Nucleic Acid Chemistry #DNA binding site #DNA-binding domain #Dimer #Drug Transport and Resistance Mechanisms #Footprinting #Gene #Isothermal titration calorimetry #Monomer #Plasma protein binding #Promoter #Transcription factor
- Analysis of Protein–RNA Interactions with Single‐Nucleotide Resolution Using iCLIP and Next‐Generation Sequencing
2011/12/14 by Julian König, Nicholas J. McGlincy, Jernej Ule · 1 citation
Biochemistry, Genetics and Molecular Biology · #RNA and protein synthesis mechanisms #RNA Research and Splicing #RNA modifications and cancer #Computational biology #RNA-binding protein #RNA #Nucleotide #Biology #Gene #Binding site #Genetics
- The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
2011/11/23 by K. Saraboji, Kadhirvel Saraboji, M. Håkansson +11 · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Binding site #Biochemistry #Chemistry #Computational chemistry #Crystallography #Galectins and Cancer Biology #Glycosylation and Glycoproteins Research #Hydrogen bond #Isothermal titration calorimetry #Ligand (biochemistry) #Molecular dynamics #Molecular recognition #Molecule #Nuclear magnetic resonance spectroscopy #Organic chemistry #Physical chemistry #Stereochemistry #Toxin Mechanisms and Immunotoxins
- N2O binding at a [4Cu:2S] copper–sulphur cluster in nitrous oxide reductase
2011/08/11 by Anja Pomowski, Walter G. Zumft, Peter M. H. Kroneck +1 · 2 citations
Chemistry · Energy · Environmental Science · #Active site #Bacteria #Binding site #Biochemistry #Bioinorganic chemistry #Chemistry #Cluster (spacecraft) #Copper #Crystallography #Enzyme #Inorganic chemistry #Metal #Metal-Catalyzed Oxygenation Mechanisms #Metalloenzymes and iron-sulfur proteins #Microbial Fuel Cells and Bioremediation #Nitrate reductase #Nitrite reductase #Nitrogen #Nitrous oxide #Nitrous-oxide reductase #Organic chemistry #Pseudomonas stutzeri #Stereochemistry #Substrate (aquarium)
- Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
2011/07/10 by Tomas Malinauskas, A.R. Aricescu, A Radu Aricescu +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #Binding site #Biochemistry #Biology #Cancer-related gene regulation #Cell biology #Chemistry #Fibroblast Growth Factor Research #Plasma protein binding #Signal transduction #Wnt signaling pathway #Wnt/β-catenin signaling in development and cancer
- Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
2010/04/01 by Markus Hafner, Markus Landthaler, Lukas Burger +13 · 20 citations
Biochemistry, Genetics and Molecular Biology · #Binding site #Biology #Computational biology #Gene #Gene expression #Genetics #Heterogeneous ribonucleoprotein particle #Polyadenylation #RNA #RNA Research and Splicing #RNA and protein synthesis mechanisms #RNA modifications and cancer #RNA-binding protein #Ribonucleoprotein #Three prime untranslated region #Transcriptome #Untranslated region #microRNA
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