- Insights into the Mechanism of Ozone Activation and Singlet Oxygen Generation on N-Doped Defective Nanocarbons: A DFT and Machine Learning Study
2022/05/26 by Guangfei Yu, Yiqiu Wu, Hongbin Cao +4 · 7 citations
Chemistry · Energy · Materials Science · #Active site #Adsorption #Atomic physics #Catalysis #Catalytic Processes in Materials Science #Chemistry #Computational chemistry #Density functional theory #Doping #Electrocatalysts for Energy Conversion #Electrochemical Analysis and Applications #Excited state #Materials science #Molecule #Optoelectronics #Organic chemistry #Oxygen #Oxygen atom #Photochemistry #Physical chemistry #Physics #Reaction mechanism #Reactive oxygen species #Singlet oxygen #Singlet state
- Metal Dependence of the Xylose Isomerase fromPiromycessp. E2 Explored by Activity Profiling and Protein Crystallography
2017/10/18 by Misun Lee, Henriëtte J. Rozeboom, H.J. Rozeboom +5 · 13 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Medicine · #Active site #Biochemical and Molecular Research #Biochemistry #Chemistry #Enzyme #Enzyme Structure and Function #Fermentation #Histidine #Isomerase #Metal #Organic chemistry #Pancreatic function and diabetes #Stereochemistry #Xylose #Xylose isomerase #Xylose metabolism
- Arginase of Helicobacter Gastric Pathogens Uses a Unique Set of Non-catalytic Residues for Catalysis
2017/03/01 by Ginto George, Mamata Kombrabail, Nikunj Raninga +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Amino acid #Arginase #Arginine #Biochemical and Molecular Research #Biochemistry #Biology #Catalysis #Catalytic triad #Chemistry #Clostridium difficile and Clostridium perfringens research #Genetics #Helicobacter pylori #Helicobacter pylori-related gastroenterology studies
- Transition state theory for enzyme kinetics
2015/05/23 by Donald G. Truhlar · 11 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Mathematics · #Activation energy #Active site #Biochemistry #Chemistry #Classical mechanics #Condensed matter physics #Enzyme #Enzyme kinetics #Hemoglobin structure and function #Kinetics #Mathematics #Non-equilibrium thermodynamics #Photosynthetic Processes and Mechanisms #Physical chemistry #Physics #Protein Structure and Dynamics #Quantization (signal processing) #Quantum tunnelling #Reaction rate constant #State (computer science) #Statistical physics #Thermodynamics #Transition (genetics) #Transition state theory
- Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
2014/03/19 by Brendan J. Hilbert, Steven R. Grossman, Celia A. Schiffer +1 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Active site #Binding site #Biochemistry #Biology #Cancer-related gene regulation #Cell biology #Chemistry #Dehydrogenase #Enzyme #Genetic Syndromes and Imprinting #Hydrolase #Kruppel-like factors research #NAD+ kinase #Stereochemistry #Substrate (aquarium)
- Molecular basis of [FeFe]-hydrogenase function
2013/03/16 by Martin Winkler, Julian Esselborn, Thomas Happe · 31 citations
Chemistry · Energy · Materials Science · #Active site #Biochemistry #Biology #Chemistry #Cofactor #Combinatorial chemistry #Electrocatalysts for Energy Conversion #Enzyme #Function (biology) #Gene #Hydrogen Storage and Materials #Hydrogenase #Materials science #Metalloenzymes and iron-sulfur proteins #Metalloprotein #Mutagenesis #Mutation #Nanotechnology
- Water Molecules in the Nucleotide Binding Cleft of Actin: Effects on Subunit Conformation and Implications for ATP Hydrolysis
2011/08/14 by Marissa G. Saunders, Gregory A. Voth · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #ATP hydrolysis #ATPase #Actin #Active site #Advanced Fluorescence Microscopy Techniques #Biochemistry #Biology #Biophysics #Catalysis #Cellular Mechanics and Interactions #Chemistry #Crystallography #Deprotonation #Enzyme #Microtubule and mitosis dynamics #Nucleotide #Organic chemistry #Protein filament #Protein structure #Protein subunit
- N2O binding at a [4Cu:2S] copper–sulphur cluster in nitrous oxide reductase
2011/08/11 by Anja Pomowski, Walter G. Zumft, Peter M. H. Kroneck +1 · 2 citations
Chemistry · Energy · Environmental Science · #Active site #Bacteria #Binding site #Biochemistry #Bioinorganic chemistry #Chemistry #Cluster (spacecraft) #Copper #Crystallography #Enzyme #Inorganic chemistry #Metal #Metal-Catalyzed Oxygenation Mechanisms #Metalloenzymes and iron-sulfur proteins #Microbial Fuel Cells and Bioremediation #Nitrate reductase #Nitrite reductase #Nitrogen #Nitrous oxide #Nitrous-oxide reductase #Organic chemistry #Pseudomonas stutzeri #Stereochemistry #Substrate (aquarium)
- Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone
2011/05/20 by Wangsa T. Ismaya, Henriëtte J. Rozeboom, H.J. Rozeboom +6 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Nursing · #Active site #Agaricus bisporus #Biochemical Analysis and Sensing Techniques #Biochemistry #Chemistry #Dimer #Enzyme #Mushroom #Organic chemistry #Phytochemicals and Antioxidant Activities #Protein subunit #Stereochemistry #Tetramer #Tropolone #Tyrosinase #melanin and skin pigmentation
- Mapping active site residues in glutamate‐5‐kinase. The substrate glutamate and the feed‐back inhibitor proline bind at overlapping sites
2006/10/20 by Isabel Pérez-Arellano, Isabel Pérez‐Arellano, Vicente Rubio +2 · 9 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Active site #Amino acid #Binding site #Biochemistry #Biology #Chemistry #Enzyme #Enzyme Structure and Function #Glutamate receptor #Mass Spectrometry Techniques and Applications #Proline #Protein Structure and Dynamics #Receptor #Stereochemistry #Substrate (aquarium) #Transferase
- Crystal Structure of NADP(H)-Dependent 1,5-Anhydro-d-fructose Reductase from Sinorhizobium morelense at 2.2 Å Resolution: Construction of a NADH-Accepting Mutant and Its Application in Rare Sugar Synthesis,
2006/08/01 by Tresfore Dambe, Tresfore R. Dambe, Annette M. Kühn +4 · 9 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Binding site #Biochemistry #Chemistry #Cofactor #Diet, Metabolism, and Disease #Enzyme #Metabolism, Diabetes, and Cancer #Moiety #Mutant #NAD+ kinase #Oxidoreductase #Plant nutrient uptake and metabolism #Reductase #Site-directed mutagenesis #Stereochemistry
- Proteasome Assembly Triggers a Switch Required for Active-Site Maturation
2006/07/01 by Susanne Witt, Young Do Kwon, Michal Sharon +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Biochemistry #Biology #Biophysics #Cell biology #Chemistry #Cleavage (geology) #Enzyme #Gene #Glycosylation and Glycoproteins Research #Mutant #Peptidase Inhibition and Analysis #Proteasome #Ubiquitin and proteasome pathways
- Role of Protein Dynamics in Reaction Rate Enhancement by Enzymes
2005/10/08 by Pratul K. Agarwal · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Physics and Astronomy · #Active site #Biochemistry #Catalysis #Chemical physics #Chemistry #Computational chemistry #Enzyme #Enzyme catalysis #Function (biology) #Isomerization #Lipid Membrane Structure and Behavior #Molecular dynamics #Protein Structure and Dynamics #Protein dynamics #Protein engineering #Protein structure #Reaction coordinate #Solvation #Solvent #Spectroscopy and Quantum Chemical Studies #Stereochemistry #Transition state
- Crystal Structure of Phenylalanine Ammonia Lyase: Multiple Helix Dipoles Implicated in Catalysis,
2004/08/20 by Joseph C. Calabrese, Douglas B. Jordan, Amechand Boodhoo +2 · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Active site #Amino acid #Biochemistry #Biology #Chemistry #Crystallography #Enzyme #Enzyme Structure and Function #Helix (gastropod) #Lyase #Phenylalanine #Phenylalanine ammonia-lyase #Plant Gene Expression Analysis #Polyamine Metabolism and Applications #Protein structure #Residue (chemistry) #Stereochemistry
- Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex
2004/07/01 by Yinong Zong, T.W. Bice, Todd W. Bice +7 · 26 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Social Sciences · #Active site #Binding site #Biochemical and Structural Characterization #Biochemistry #Botanical Research and Chemistry #Chemistry #Enzyme #French Urban and Social Studies #Microbial Natural Products and Biosynthesis #Peptide #Peptide sequence #Protein Data Bank (RCSB PDB) #Protein structure #Serine #Sortase #Sortase A #Stereochemistry #Threonine
- Crystal Structures of Prostaglandin D2 11-Ketoreductase (AKR1C3) in Complex with the Nonsteroidal Anti-Inflammatory Drugs Flufenamic Acid and Indomethacin
2004/03/01 by Andrew L. Lovering, Jon P. Ride, Christopher M. Bunce +3 · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Aldo-keto reductase #Aldose Reductase and Taurine #Biochemistry #Cancer research #Chemistry #Eicosanoids and Hypertension Pharmacology #Enzyme #Flufenamic acid #Heme Oxygenase-1 and Carbon Monoxide #Medicine #Pharmacology #Prostaglandin #Reductase
- Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase
2003/06/30 by Véronique Hannaert, Marie‐Astrid Albert, Daniel J. Rigden +9 · 20 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · Medicine · #Active site #Amino acid #Biochemistry #Biology #Enolase #Enzyme #Enzyme Structure and Function #Enzyme kinetics #Gene #Hydrolase #Molecular biology #Peptidase Inhibition and Analysis #Protein Structure and Dynamics #Saccharomyces cerevisiae #Trypanosoma brucei #Yeast
- Molybdenum and tungsten in biology
2002/07/01 by Russ Hille · 2 citations
Chemistry · Energy · Medicine · #Active site #Biochemistry #Catalysis #Chemistry #Inorganic chemistry #Materials science #Metal complexes synthesis and properties #Metal-Catalyzed Oxygenation Mechanisms #Metalloenzymes and iron-sulfur proteins #Metallurgy #Molybdenum #Nanotechnology #Transition metal #Tungsten #Tungsten Compounds
- Engineering the properties of a cold active enzyme through rational redesign of the active site
2001/10/01 by Iason Tsigos, Konstantinos Mavromatis, Maria Tzanodaskalaki +3 · 5 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Alkaline Phosphatase Research Studies #Biochemical and Molecular Research #Biochemistry #Biology #Biophysics #Chemistry #Enzyme #Enzyme assay #Flexibility (engineering) #Folate and B Vitamins Research #Gene #Mutagenesis #Mutant #Protein engineering #Psychrophile #Site-directed mutagenesis #Stereochemistry #Strain (injury) #Wild type
- Elucidating the Process of Activation of Methyl-Coenzyme M Reductase
2001/01/01 by Divya Prakash, Yonnie Wu, Sang-Jin Suh +3 · 29 citations
Arts and Humanities · Biochemistry, Genetics and Molecular Biology · Chemistry · Energy · Neuroscience · #Active site #Biochemistry #Biology #Chemistry #Coenzyme A #Cofactor #Enzyme #French Historical and Cultural Studies #Metalloenzymes and iron-sulfur proteins #Neurological diseases and metabolism #Porphyrin Metabolism and Disorders #Reductase #Stereochemistry
- The Molecular Mechanism of Lead Inhibition of Human Porphobilinogen Synthase
2001/01/01 by Eileen K. Jaffe, Jacob Martins, Jian Li +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Environmental Science · Chemistry · #Porphyrin Metabolism and Disorders #Folate and B Vitamins Research #Arsenic contamination and mitigation #Chemistry #Mutant #Cysteine #Allosteric regulation #Ligand (biochemistry) #Active site #Stereochemistry #Catalytic cycle #Biochemistry #Enzyme #Receptor
- The active sites of molybdenum- and tungsten-containing enzymes
1998/04/01 by J McMaster, Jonathan McMaster, John H. Enemark +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Energy · #Active site #Biochemistry #Chemistry #Cofactor #Enzyme #Hydroxylation #Inorganic chemistry #Metal-Catalyzed Oxygenation Mechanisms #Metalloenzymes and iron-sulfur proteins #Molybdenum #Molybdenum cofactor #Organic chemistry #Pterin #RNA modifications and cancer #Stereochemistry #Tungsten
- Crystal Structures of Substrates and Products Bound to the Phosphoglycerate Kinase Active Site Reveal the Catalytic Mechanism
1998/03/01 by B Bernstein, Bradley E. Bernstein, Wim G. J. Hol · 23 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Biochemical and Molecular Research #Biochemistry #Carbohydrate Chemistry and Synthesis #Catalysis #Chemistry #Crystallography #Enzyme #Glycogen Storage Diseases and Myoclonus #Nucleotide #Phosphoglycerate kinase #Stereochemistry #Ternary complex
- Crystal Structure of Pig Pancreatic α‐amylase Isoenzyme II, in Complex with the Carbohydrate Inhibitor Acarbose
1996/06/01 by C. Gilles, Coralie Gilles, Jean‐Pierre Astier +4 · 19 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Nursing · #Acarbose #Active site #Biochemistry #Carbohydrate #Chemistry #Crystal (programming language) #Crystal structure #Crystallography #Enzyme #Enzyme Production and Characterization #Enzyme Structure and Function #Ligand (biochemistry) #Molecule #Organic chemistry #Receptor #Stereochemistry #Vitamin K Research Studies
- X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes
1993/07/01 by Clayton R. Randall, Yan Zang, Anne E. True +7 · 17 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Antibiotic Resistance in Bacteria #Carboxylate #Chemistry #Crystallography #Cysteine #Enzyme #Ferrous #Ligand (biochemistry) #Metal complexes synthesis and properties #Metal-Catalyzed Oxygenation Mechanisms #Organic chemistry #Stereochemistry #Substrate (aquarium)
- Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure
1984/04/01 by Jack F. Kirsch, Gregor Eichele, Geoffrey C. Ford +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Active site #Amino Acid Enzymes and Metabolism #Biochemistry #Chemistry #Cofactor #Enzyme #Enzyme Structure and Function #Lyase #Moiety #Protein Structure and Dynamics #Pyridoxal #Stereochemistry #Transamination
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
1973/12/01 by Cheng Yung-Chi, Yung-Chi Cheng, William H. Prusoff · 95 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Active site #Biochemistry #Biology #Chemistry #Enzyme #Enzyme kinetics #Kinetics #Non-competitive inhibition #Physics #Protein purification and stability #Receptor Mechanisms and Signaling #Stereochemistry #Substrate (aquarium) #Uncompetitive inhibitor #Viral Infectious Diseases and Gene Expression in Insects