- Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory
2022/03/23 by Angus D. Cowan, Alessio Ciulli · 8 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biochemistry #Biology #Cell biology #Chemistry #Computational biology #DNA ligase #Enzyme #Peptidase Inhibition and Analysis #Proteasome #Protein Degradation and Inhibitors #Protein degradation #Protein structure #Proteolysis #Substrate specificity #Ternary complex #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase #Ubiquitin-Protein Ligases
- Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
2017/11/08 by Scott J. Hughes, Scott J. Hughes, Alessio Ciulli · 3 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biochemistry #Biology #Chemistry #Computational biology #Computer science #Cooperativity #Enzyme #Gene #Intramolecular force #Molecular recognition #Molecule #Peptidase Inhibition and Analysis #Plasma protein binding #Protein Data Bank #Protein Degradation and Inhibitors #Protein design #Protein ligand #Protein structure #Small molecule #Stereochemistry #Target protein #Ternary complex #Ternary operation #Ubiquitin and proteasome pathways
- PhLP3 Modulates CCT-mediated Actin and Tubulin Folding via Ternary Complexes with Substrates
2006/01/17 by Peter C. Stirling, Jorge Cuéllar, Gabriel Alfaro +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · #Heat shock proteins research #Cellular Mechanics and Interactions #14-3-3 protein interactions #Tubulin #Ternary operation #Folding (DSP implementation) #Biophysics #Chemistry #Actin #Cell biology #Ternary complex #Microtubule #Biochemistry #Biology #Computer science #Engineering #Programming language
- Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
2003/09/08 by Scott Classen, Stéphane Olland, James M. Berger · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #ATPase #Adenosine triphosphate #Binding site #Biochemistry #Biology #Cancer therapeutics and mechanisms #Chemistry #DNA #DNA Repair Mechanisms #DNA gyrase #Drug Transport and Resistance Mechanisms #Enzyme #Escherichia coli #Gene #Mutation #Point mutation #Protein subunit #Saccharomyces cerevisiae #Ternary complex #Topoisomerase #Yeast
- Crystal Structures of Substrates and Products Bound to the Phosphoglycerate Kinase Active Site Reveal the Catalytic Mechanism
1998/03/01 by Bradley E. Bernstein, B Bernstein, Wim G. J. Hol · 23 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Biochemical and Molecular Research #Biochemistry #Carbohydrate Chemistry and Synthesis #Catalysis #Chemistry #Crystallography #Enzyme #Glycogen Storage Diseases and Myoclonus #Nucleotide #Phosphoglycerate kinase #Stereochemistry #Ternary complex
- Universal chemical assay for the detection and determination of siderophores
1987/01/01 by Bernhard Schwyn, B. Schwyn, J. B. Neilands +1 · 67 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Nursing · #Agar #Agar plate #Bacteria #Biochemistry #Biology #Chelation #Chemistry #Chromatography #Enterobactin #Escherichia coli #Inorganic chemistry #Legume Nitrogen Fixing Symbiosis #Magnetic and Electromagnetic Effects #Microbial Metabolites in Food Biotechnology #Mutant #Nuclear chemistry #Orange (colour) #Siderophore #Ternary complex