Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression

2016/03/31 by Iván M. Lengyel, Luis G. Morelli · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Physics and Astronomy · #Autoregulation #Bacterial Genetics and Biotechnology #Binding site #Biology #Bursting #Cell biology #DNA binding site #Gene #Gene Regulatory Network Analysis #Gene expression #Genetics #Neuroscience #Promoter #Psychological repression #RNA Research and Splicing #Repressor #Transcription (linguistics) #Transcription factor #physics.bio-ph #q-bio.MN

paper · pdf · doi:10.1103/physreve.95.042412

published as Phys. Rev. E 95, 042412 (2017)

openalex publication_date 2017/04/26 · arxiv created 2017/05/20 · arxiv updated 2017/05/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters. We study a stochastic description of negative autoregulation with multiple binding sites for the repressor. We find that increasing the number of binding sites induces regular bursting of gene products. By tuning the threshold for repression, we show that multiple binding sites can also suppress fluctuations. Our results highlight possible roles for the presence of multiple binding sites of negative autoregulators.

Citations

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