Crystallographic and EPR-based characterisation of Cu 2+ -binding to serum albumin: ATCUN coordination and additional sites

2026/01/01 by Michal Gucwa, K.B. Handing, Vanessa Amanda Bijak +10 · 3 voices
Biochemistry, Genetics and Molecular Biology · Nursing · Medicine · #Protein Interaction Studies and Fluorescence Analysis #Trace Elements in Health #Metal complexes synthesis and properties

paper · pdf · doi:10.1039/d6qi00150e

Abstract

equivalents. These findings support a dynamic, multi-site binding model in which short-range distances arise from ATCUN and site B co-occupancy, while longer-range peaks reflect contributions from distal histidine sites.

Discussions

• Just published: copper(II) binding to Human Serum Albumin. 1st structure including the ATCUN site that is square planar as expected. There are multiple copper(II) sites and EPR (including hyperfine an [bsky, 15 points, 1 comments]
• Cu(II) binding to Human Serum Albumin. 1st structure including the square-planar ATCUN site, as expected. Multiple Cu(II) sites exist, and EPR reveals occupation of several sites at low loading. More [bsky, 2 points, 0 comments]
• 🔔Welcome to Issue 9! Please read the Inside Front Cover article: Crystallographic and EPR-based characterisation of Cu²⁺-binding to serum albumin: ATCUN coordination and additional sites by Alan J [bsky, 1 points, 0 comments]

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