Yves Pommier
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012/10/31 by Junko Murai, Shar-yin N. Huang, Benu Brata Das +7 · 46 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Engineering · #PARP inhibition in cancer therapy #DNA Repair Mechanisms #Integrated Circuits and Semiconductor Failure Analysis
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
2010/05/01 by Yves Pommier, Elisabetta Leo, Hongliang Zhang +1 · 10 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Antibiotics Pharmacokinetics and Efficacy
- Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
2000/09/19 by Mark Cushman, Muthusamy Jayaraman, Jeffrey A. Vroman +5 · 15 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
2005/02/24 by Bart L. Staker, M.D. Feese, Mark Cushman +4 · 18 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Antibiotics Pharmacokinetics and Efficacy #Lung Cancer Research Studies
- DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009/05/29 by Yves Pommier · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #HIV/AIDS drug development and treatment #Synthesis and bioactivity of alkaloids
- Topoisomerase I inhibitors: camptothecins and beyond
2006/09/22 by Yves Pommier · 13 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Lung Cancer Research Studies #Neutropenia and Cancer Infections
- Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
2003/11/21 by Muthukaman Nagarajan, Xiangshu Xiao, Smitha Antony +3 · 11 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Cancer therapeutics and mechanisms #Synthesis and Biological Evaluation #Synthesis and Biological Activity
- Topoisomerase I inhibitors: selectivity and cellular resistance
1999/10/01 by Yves Pommier, Philippe Pourquier, Yoshimasa Urasaki +2 · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
2009/04/22 by Yves Pommier, Mark Cushman · 5 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Antibiotics Pharmacokinetics and Efficacy #Lung Cancer Research Studies
- Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 11 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Induction of a Common Pathway of Apoptosis by Staurosporine
1994/04/01 by Richard Bertrand, Eric Solary, Éric Solary +4 · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cell death mechanisms and regulation #Metal complexes synthesis and properties
- Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
2005/06/23 by Alexandra Ioanoviciu, Smitha Antony, Yves Pommier +3 · 12 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
2006/02/01 by Christophe Marchand, Smitha Antony, Kurt W. Kohn +6 · 5 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Neutropenia and Cancer Infections
- Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
2007/08/15 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
2004/11/06 by Smitha Antony, Glenda Kohlhagen, Keli Agama +6 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids
- Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
2008/07/17 by Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer +3 · 5 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
2007/11/01 by Smitha Antony, Keli Agama, Ze‐Hong Miao +8 · 5 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
- Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors
2007/08/04 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006/07/28 by Muthukaman Nagarajan, Andrew Morrell, Smitha Antony +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- 4-Nitroquinoline-1-Oxide Induces the Formation of Cellular Topoisomerase I-DNA Cleavage Complexes
2006/07/01 by Ze‐Hong Miao, V. Ashutosh Rao, Keli Agama +3 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #DNA Repair Mechanisms #Acute Lymphoblastic Leukemia research
- Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006/06/24 by Smitha Antony, Keli Agama, Keli K. Agama +11 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- Molecular Interaction Maps of Bioregulatory Networks: A General Rubric for Systems Biology
2005/11/03 by Kurt W. Kohn, Mirit I. Aladjem, John N. Weinstein +1 · 5 citations
Biochemistry, Genetics and Molecular Biology · #Gene Regulatory Network Analysis #Bioinformatics and Genomic Networks #Microbial Metabolic Engineering and Bioproduction
- Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids
- Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
2009/07/01 by Thomas D. Pfister, William C. Reinhold, Keli Agama +7 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neuroblastoma Research and Treatments #Lung Cancer Research Studies
- Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
2009/10/18 by Sandie Tuduri, Laure Crabbé, Chiara Conti +11 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Cancer therapeutics and mechanisms #DNA Repair Mechanisms #Genomics and Chromatin Dynamics
- Structure-Based Design, Synthesis, and Biological Studies of New Anticancer Norindenoisoquinoline Topoisomerase I Inhibitors
2010/02/15 by Yunlong Song, Zhiyu Shao, Thomas S. Dexheimer +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Lung Cancer Research Studies #Bioactive Compounds and Antitumor Agents
- Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents
2010/11/23 by Evgeny Kiselev, Thomas S. Dexheimer, Yves Pommier +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Depicting combinatorial complexity with the molecular interaction map notation
2006/10/03 by Kurt W Kohn, Kurt W. Kohn, Mirit I Aladjem +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · #Computational Drug Discovery Methods #Gene Regulatory Network Analysis #History and advancements in chemistry
- The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode
2010/06/21 by Maris A. Cinelli, Andrew Morrell, Andrew E. Morrell +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotics Pharmacokinetics and Efficacy #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission
2008/06/14 by Olivier Sordet, Abby R. Goldman, Christophe E. Redon +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Cancer therapeutics and mechanisms #Cell death mechanisms and regulation #DNA Repair Mechanisms
- Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
2010/10/06 by Robert J. Kinders, Melinda G. Hollingshead, Scott M. Lawrence +9 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Colorectal Cancer Treatments and Studies #PARP inhibition in cancer therapy
- Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints
2004/09/01 by Yves Pommier · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis of β-Lactam Compounds #Chemical Reactions and Isotopes
- Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships
2009/09/07 by Maris A. Cinelli, Brenda Cordero, Thomas S. Dexheimer +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections