Bart L. Staker
- Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
2005/02/24 by Bart L. Staker, M.D. Feese, Mark Cushman +4 · 18 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Antibiotics Pharmacokinetics and Efficacy #Lung Cancer Research Studies
- Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
2005/06/23 by Alexandra Ioanoviciu, Smitha Antony, Yves Pommier +3 · 12 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
2006/02/01 by Christophe Marchand, Smitha Antony, Kurt W. Kohn +6 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Neutropenia and Cancer Infections
- Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1
2023/09/18 by Julia Moorefield, Yagmur Konuk, Jordan O. Norman +11 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · #ATP Synthase and ATPases Research #Enzyme Structure and Function #Legionella and Acanthamoeba research
- The mechanism of topoisomerase I poisoning by a camptothecin analog
2002/11/08 by Bart L. Staker, Kathryn A. Hjerrild, M.D. Feese +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · Chemistry · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Neutropenia and Cancer Infections #Camptothecin #Topoisomerase #Topotecan #DNA #Binding site #Chemistry #Stereochemistry #Biochemistry #Cleavage (geology) #Intercalation (chemistry) #Base pair #Enzyme #Biophysics #Biology #Genetics