Mark Cushman

1. Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-c]isoquinoline system
   1978/09/01 by Mark Cushman, Leung Cheng · 10 citations
   Chemistry · Biochemistry, Genetics and Molecular Biology · #Axial and Atropisomeric Chirality Synthesis #Asymmetric Synthesis and Catalysis #Phenothiazines and Benzothiazines Synthesis and Activities
2. Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
   2000/09/19 by Mark Cushman, Muthusamy Jayaraman, Jeffrey A. Vroman +5 · 15 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
3. Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
   2005/02/24 by Bart L. Staker, M.D. Feese, Mark Cushman +4 · 18 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Antibiotics Pharmacokinetics and Efficacy #Lung Cancer Research Studies
4. Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
   2003/11/21 by Muthukaman Nagarajan, Xiangshu Xiao, Smitha Antony +3 · 11 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · #Cancer therapeutics and mechanisms #Synthesis and Biological Evaluation #Synthesis and Biological Activity
5. The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
   2009/04/22 by Yves Pommier, Mark Cushman · 5 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Antibiotics Pharmacokinetics and Efficacy #Lung Cancer Research Studies
6. Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
   2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 11 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
7. Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
   2005/06/23 by Alexandra Ioanoviciu, Smitha Antony, Yves Pommier +3 · 12 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
8. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
   2006/02/01 by Christophe Marchand, Smitha Antony, Kurt W. Kohn +6 · 5 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Neutropenia and Cancer Infections
9. Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
   2007/08/15 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
10. Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
    2004/11/06 by Smitha Antony, Glenda Kohlhagen, Keli Agama +6 · 6 citations
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids
11. Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
    2008/07/17 by Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer +3 · 5 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
12. Total synthesis of (.+-.)-chelidonine
    1980/12/01 by Mark Cushman, Tung-Chung Choong, Joseph T. Valko +1 · 2 citations
    Pharmacology, Toxicology and Pharmaceutics · Medicine · Chemistry · #Plant-based Medicinal Research #Berberine and alkaloids research #Chromatography in Natural Products
13. Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
    2007/11/01 by Smitha Antony, Keli Agama, Ze‐Hong Miao +8 · 5 citations
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
14. Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors
    2007/08/04 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
15. Total synthesis of (.+-.)-14-epicorynoline, (.+-.)-corynoline, and (.+-.)-6-oxocorynoline
    1983/05/01 by Mark Cushman, Aziz Abbaspour, Yash Pal Gupta · 2 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Traditional and Medicinal Uses of Annonaceae #Marine Sponges and Natural Products #Carbohydrate Chemistry and Synthesis
16. A Versatile Solid Phase Synthesis of Lavendustin A and Certain Biologically Active Analogs
    1996/01/01 by Rajesh Devraj, Mark Cushman · 2 citations
    Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Microbial Natural Products and Biosynthesis #Chemical Synthesis and Analysis #Synthetic Organic Chemistry Methods
17. Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
    2006/07/28 by Muthukaman Nagarajan, Andrew Morrell, Smitha Antony +8 · 4 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
18. Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
    2006/06/24 by Smitha Antony, Keli Agama, Keli K. Agama +11 · 4 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
19. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
    2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids
20. Efficient Total Synthesis of Ammosamide B
    2010/06/01 by P. Venkat Reddy, Biplab Banerjee, Mark Cushman · 1 citation
    Chemistry · Medicine · #Chemical synthesis and alkaloids #Advanced Synthetic Organic Chemistry #Microbial Natural Products and Biosynthesis
21. Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy
    2021/12/08 by Mark Cushman · 1 citation
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Chemistry · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and biological activity
22. Condensation of succinic anhydrides with Schiff bases. Scope and mechanism
    1971/11/01 by Neal Castagnoli, Mark Cushman · 2 citations
    Chemistry · Medicine · #Synthesis and biological activity #Multicomponent Synthesis of Heterocycles #Synthesis of Organic Compounds
23. Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents
    2010/11/23 by Evgeny Kiselev, Thomas S. Dexheimer, Yves Pommier +1 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
24. Synthesis of (.+-.)-thalictricavine, berlambine, and (.+-.)-canadine from a common intermediate
    1979/02/01 by Mark Cushman, Frederick W. Dekow · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Alkaloids: synthesis and pharmacology #Chemical synthesis and alkaloids #Traditional and Medicinal Uses of Annonaceae
25. Total synthesis of (.+-.)-14-epicorynoline, (.+-.)-corynoline, and (.+-.)-6-oxocorynoline [Erratum to document cited in CA98(21):179711f]
    1990/07/01 by Mark Cushman, Aziz Abbaspour, Yash Pal Gupta · 1 citation
    Chemistry · Biochemistry, Genetics and Molecular Biology · #Chemical synthesis and alkaloids #Traditional and Medicinal Uses of Annonaceae #Carbohydrate Chemistry and Synthesis
26. The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode
    2010/06/21 by Maris A. Cinelli, Andrew E. Morrell, Andrew Morrell +5 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotics Pharmacokinetics and Efficacy #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
27. A total synthesis of corydaline
    1978/01/01 by Mark Cushman, Frederick W. Dekow · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical synthesis and alkaloids #Marine Sponges and Natural Products #Synthesis and Biological Activity
28. Synthesis of epimeric 6,7-bis(trifluoromethyl)-8-ribityllumazine hydrates. Stereoselective interaction with the light riboflavin synthase of Bacillus subtilis
    1991/07/01 by Mark Cushman, Donald A. Patrick, Adelbert Bacher +1 · 1 citation
    Pharmacology, Toxicology and Pharmaceutics · Biochemistry, Genetics and Molecular Biology · Materials Science · #Fluorine in Organic Chemistry #Biochemical and Molecular Research #Enzyme Structure and Function
29. Conversion of allylic alcohols to homologous amides by N,N-dimethylformamide acetals
    1974/08/01 by G. Büchi, Mark Cushman, Hans Wüest · 1 citation
    Chemistry · Biochemistry, Genetics and Molecular Biology · #Advanced Synthetic Organic Chemistry #Chemical Synthesis and Analysis #Chemical Synthesis and Reactions
30. Activity of Indenoisoquinolines against African Trypanosomes
    2008/09/30 by Rahul P. Bakshi, Dongpei Sang, Andrew Morrell +2 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Cancer therapeutics and mechanisms #Synthesis and Biological Evaluation #Synthesis and bioactivity of alkaloids
31. Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships
    2009/09/07 by Maris A. Cinelli, Brenda Cordero, Thomas S. Dexheimer +2 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
32. Malformin C, a new metabolite of Aspergillus niger
    1976/05/01 by Robert J. Anderegg, K. Biemann, George Buechi +1 · 1 citation
    Medicine · Chemistry · #Microbial Natural Products and Biosynthesis #Fungal Biology and Applications #Chemical synthesis and alkaloids
33. Structure-Based Design, Synthesis, and Biological Studies of New Anticancer Norindenoisoquinoline Topoisomerase I Inhibitors
    2010/02/15 by Yunlong Song, Zhiyu Shao, Thomas S. Dexheimer +3 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Lung Cancer Research Studies #Bioactive Compounds and Antitumor Agents
34. Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC
    2019/06/03 by Kai‐Bo Wang, Mohamed Elsayed, Guanhui Wu +3 · 2 citations
    Biochemistry, Genetics and Molecular Biology · #Cancer therapeutics and mechanisms #DNA and Nucleic Acid Chemistry #Advanced biosensing and bioanalysis techniques