Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

2004/11/06 by Smitha Antony, Glenda Kohlhagen, Keli Agama +6 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids

paper · doi:10.1124/mol.104.003889

openalex publication_date 2004/11/06 · crossref created 2004/11/06 · crossref issued 2005/02/01 · crossref published 2005/02/01 · crossref published-print 2005/02/01 · crossref deposited 2025/02/20 · openalex created_date 2025/10/10 · crossref indexed 2026/05/12 · openalex updated_date 2026/08/01

Citations

• Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
• Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

Cited by

• Topoisomerase I inhibitors: camptothecins and beyond
• Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
• The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
• Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
• Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
• Topoisomerase inhibitor [wikipedia]