Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

2006/06/24 by Smitha Antony, Keli K. Agama, Keli Agama +11 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections

paper · doi:10.1124/mol.106.024372

openalex publication_date 2006/06/24 · crossref created 2006/06/24 · crossref issued 2006/09/01 · crossref published 2006/09/01 · crossref published-print 2006/09/01 · openalex created_date 2016/06/24 · crossref deposited 2025/02/19 · crossref indexed 2025/12/03 · openalex updated_date 2026/08/01

Citations

• Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
• Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
• Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
• Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
• Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
• Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
• Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-c]isoquinoline system

Cited by

• Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
• The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
• Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
• Topoisomerase inhibitor [wikipedia]