Keli Agama
- Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 11 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
2004/11/06 by Smitha Antony, Glenda Kohlhagen, Keli Agama +6 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids
- Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
2007/11/01 by Smitha Antony, Keli Agama, Ze‐Hong Miao +8 · 5 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006/07/28 by Muthukaman Nagarajan, Andrew Morrell, Smitha Antony +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- 4-Nitroquinoline-1-Oxide Induces the Formation of Cellular Topoisomerase I-DNA Cleavage Complexes
2006/07/01 by Ze‐Hong Miao, V. Ashutosh Rao, Keli Agama +3 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #DNA Repair Mechanisms #Acute Lymphoblastic Leukemia research
- Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006/06/24 by Smitha Antony, Keli K. Agama, Keli Agama +11 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
2009/07/01 by Thomas D. Pfister, William C. Reinhold, Keli Agama +7 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neuroblastoma Research and Treatments #Lung Cancer Research Studies
- The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode
2010/06/21 by Maris A. Cinelli, Andrew Morrell, Andrew E. Morrell +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotics Pharmacokinetics and Efficacy #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections