Alexandra Ioanoviciu

1. Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
   2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 11 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
2. Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
   2005/06/23 by Alexandra Ioanoviciu, Smitha Antony, Yves Pommier +3 · 12 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
3. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
   2006/02/01 by Christophe Marchand, Smitha Antony, Kurt W. Kohn +6 · 5 citations
   Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Neutropenia and Cancer Infections
4. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
   2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids