Andrew Morrell
- Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 11 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
2007/08/15 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
2008/07/17 by Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer +3 · 5 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
2007/11/01 by Smitha Antony, Keli Agama, Ze‐Hong Miao +8 · 5 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
- Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors
2007/08/04 by Andrew Morrell, Michael S. Placzek, Seth Parmley +4 · 6 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids #Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006/07/28 by Muthukaman Nagarajan, Andrew Morrell, Smitha Antony +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006/06/24 by Smitha Antony, Keli Agama, Keli K. Agama +11 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids
- Activity of Indenoisoquinolines against African Trypanosomes
2008/09/30 by Rahul P. Bakshi, Dongpei Sang, Andrew Morrell +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #Cancer therapeutics and mechanisms #Synthesis and Biological Evaluation #Synthesis and bioactivity of alkaloids
- The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode
2010/06/21 by Maris A. Cinelli, Andrew Morrell, Andrew E. Morrell +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotics Pharmacokinetics and Efficacy #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections