Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay

2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids

paper · doi:10.1016/j.bmcl.2006.05.048

openalex publication_date 2006/06/06 · crossref created 2006/06/06 · crossref issued 2006/08/01 · crossref published 2006/08/01 · crossref published-print 2006/08/01 · openalex created_date 2025/10/10 · crossref deposited 2025/10/18 · crossref indexed 2026/05/12 · openalex updated_date 2026/08/01

Citations

• Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
• Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
• Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
• Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
• Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-c]isoquinoline system

Cited by

• Topoisomerase I inhibitors: camptothecins and beyond
• The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
• Activity of Indenoisoquinolines against African Trypanosomes
• Topoisomerase inhibitor [wikipedia]