Topoisomerase I inhibitors: camptothecins and beyond

2006/09/22 by Yves Pommier · 13 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Lung Cancer Research Studies #Neutropenia and Cancer Infections

paper · pdf · doi:10.1038/nrc1977

openalex publication_date 2006/09/22 · crossref created 2006/09/22 · crossref issued 2006/10/01 · crossref published 2006/10/01 · crossref published-print 2006/10/01 · crossref deposited 2023/05/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/01

Citations

• Topoisomerase I inhibitors: selectivity and cellular resistance
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
• Histone H2A variants H2AX and H2AZ
• Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
• Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
• Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
• Induction of a Common Pathway of Apoptosis by Staurosporine
• Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives
• Molecular Interaction Maps of Bioregulatory Networks: A General Rubric for Systems Biology

Cited by

• Perspectives on Biologically Active Camptothecin Derivatives
• Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships
• Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission
• Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
• Recent developments in topoisomerase-targeted cancer chemotherapy
• Topoisomerases as anticancer targets
• DNA topoisomerases as molecular targets for anticancer drugs
• Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
• Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
• The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
• Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
• Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
• Topoisomerase inhibitor [wikipedia]