Melinda G. Hollingshead
- Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006/09/26 by Muthukaman Nagarajan, Andrew Morrell, Alexandra Ioanoviciu +6 · 12 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Bioactive Compounds and Antitumor Agents #Synthesis and bioactivity of alkaloids
- Antiviral (RNA) Activity of Selected Amaryllidaceae Isoquinoline Constituents and Synthesis of Related Substances
1992/11/01 by Bjarne Gabrielsen, Thomas P. Monath, John W. Huggins +17 · 3 citations
Chemistry · #Chemical synthesis and alkaloids
- Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006/07/28 by Muthukaman Nagarajan, Andrew Morrell, Smitha Antony +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cancer therapeutics and mechanisms #Synthesis and biological activity #Bioactive Compounds and Antitumor Agents
- Bisindenoisoquinoline Bis-1,3-(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylaminopropane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006/06/24 by Smitha Antony, Keli K. Agama, Keli Agama +11 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections
- Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
2006/06/06 by Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Neutropenia and Cancer Infections #Synthesis and bioactivity of alkaloids
- Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
2010/10/06 by Robert J. Kinders, Melinda G. Hollingshead, Scott M. Lawrence +9 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #Colorectal Cancer Treatments and Studies #PARP inhibition in cancer therapy