- Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN -Amplified Cancers
2025/08/07 by Giulia Montuori, Fengyu Tu, Di Qin +33 · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer Genomics and Diagnostics #Cancer research #Cell cycle #Copy-number variation #Extrachromosomal DNA #Gene #Gene dosage #Gene duplication #Gene expression #Genetics #Genome #Neuroblastoma Research and Treatments #Oncogene #Phenotype #Pluripotent Stem Cells Research
- Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends
2024/12/10 by Saishree S. Iyer, Fangrui Chen, Funso E. Ogunmolu +21 · 8 citations
Biochemistry, Genetics and Molecular Biology · #Biochemistry #Biology #Cell #Cell biology #Cell cycle #Centriole #Centrosome #Ciliogenesis #Cilium #Genetic and Kidney Cyst Diseases #Microtubule #Microtubule and mitosis dynamics #Microtubule nucleation #Microtubule-associated protein #Nuclear Structure and Function
- The central scaffold protein CEP350 coordinates centriole length, stability, and maturation
2022/10/31 by Onur Rojhat Karasu, Annett Neuner, Enrico Salvatore Atorino +2 · 7 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Cell #Cell biology #Cell cycle #Centriole #Centrosome #Genetics #Microtubule #Microtubule and mitosis dynamics #Photosynthetic Processes and Mechanisms #Protist diversity and phylogeny #Scaffold protein #Signal transduction
- MNX1-AS1 Promotes Phase Separation of IGF2BP1 to Drive c-Myc–Mediated Cell-Cycle Progression and Proliferation in Lung Cancer
2022/10/10 by Qingqing Zhu, Chongguo Zhang, Tianyu Qu +7 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer research #Cancer-related Molecular Pathways #Cancer-related molecular mechanisms research #Carcinogenesis #Cell cycle #Cell growth #E2F #E2F1 #Ferroptosis and cancer prognosis #Genetics #Lung cancer #Medicine #Oncology
- Evidence of immunogenic cancer cell death induced by honey-processed Astragalus polysaccharides in vitro and in vivo
2021/11/23 by Xinrui Sha, Xia Xu, Shuangye Liao +3 · 14 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Biochemistry #Biology #CD40 #CD8 #CD80 #CD86 #Cell biology #Cell cycle #Cell growth #Cytotoxic T cell #Flow cytometry #Immune system #Immunogenic cell death #Immunology #In vitro #Major histocompatibility complex #Metabolomics and Mass Spectrometry Studies #Molecular biology #Programmed cell death #T cell #Tea Polyphenols and Effects #Traditional Chinese Medicine Analysis
- A ciliopathy complex builds distal appendages to initiate ciliogenesis
2021/06/15 by Dhivya Kumar, Addison B. Rains, Addison Rains +15 · 23 citations
Biochemistry, Genetics and Molecular Biology · #Anatomy #Appendage #Biology #Cell #Cell biology #Cell cycle #Centriole #Centrosome #Ciliogenesis #Ciliopathies #Ciliopathy #Cilium #Genetic and Kidney Cyst Diseases #Genetics #Hedgehog Signaling Pathway Studies #Microtubule #Microtubule and mitosis dynamics
- In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis
2021/03/03 by Francisco Reigosa-Chamorro, Francisco Reigosa, Luís R. Raposo +9 · 11 citations
Chemistry · #Angiogenesis #Apoptosis #Biochemistry #Biology #Cancer research #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Cell biology #Cell culture #Cell cycle #Chemistry #Chorioallantoic membrane #Click Chemistry and Applications #Cytotoxicity #In vitro #In vivo #Intracellular
- Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences
2020/12/28 by C. Louwrens Braal, Elisabeth M. Jongbloed, Saskia M. Wilting +5 · 27 citations
Medicine · #Advanced Breast Cancer Therapies #Breast cancer #Cancer #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Cyclin-dependent kinase #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Internal medicine #Medicine #Metastatic breast cancer #Oncology #Palbociclib #Pharmacodynamics #Pharmacokinetics #Pharmacology
- Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence
2020/12/02 by Kristbjorn O. Gudmundsson, Nhu Nguyen, Kevin Oakley +7 · 12 citations
Immunology and Microbiology · Medicine · #Biology #Cancer research #Cell biology #Cell cycle #Conditional gene knockout #Gene #Gene expression #Genetics #Haematopoiesis #Hematopoietic Stem Cell Transplantation #Hematopoietic stem cell #Immune Cell Function and Interaction #PRDM16 #Phenotype #Regulator #Stem cell #T-cell and B-cell Immunology #Transcription factor
- Knockdown of ALPK2 blocks development and progression of renal cell carcinoma
2020/04/22 by Jie Jiang, Peng Han, Jian Qian +4 · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Breast Cancer Therapies #Apoptosis #Biology #Cancer research #Cancer-related Molecular Pathways #Cell #Cell cycle #Cell growth #Cyclin D1 #Cyclin-dependent kinase 6 #Flow cytometry #Gene knockdown #Microtubule and mitosis dynamics #Molecular biology #PI3K/AKT/mTOR pathway #Protein kinase B
- Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis
2020/02/14 by Linda Viol, Shoji Hata, Ana Pastor-Peidro +6 · 23 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Aurora A kinase #Biology #Cell #Cell biology #Cell cycle #Centriole #Centrosome #Centrosome cycle #Chemistry #Ciliogenesis #Cilium #Genetic and Kidney Cyst Diseases #Genetics #Hedgehog Signaling Pathway Studies #Microtubule and mitosis dynamics #Mitosis
- Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
2019/06/06 by Marc Hafner, Caitlin E. Mills, Kartik Subramanian +8 · 2 citations
Medicine · #Advanced Breast Cancer Therapies #Biology #Breast cancer #CDK inhibitor #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Computational biology #Cyclin-dependent kinase #Cyclin-dependent kinase 1 #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Genetics #Internal medicine #Kinase #Medicine #Metastatic breast cancer #Palbociclib #Pharmacology #Protein kinase A
- Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review
2018/11/27 by Kamal Pandey, Hee Jung An, Hee‐Jung An +8 · 26 citations
Medicine · #Acquired resistance #Advanced Breast Cancer Therapies #Bioinformatics #Biology #Breast cancer #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Cyclin-dependent kinase #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Internal medicine #Mechanism (biology) #Medicine #Metastatic breast cancer #Palbociclib #Pharmacology
- A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability
2018/09/04 by Jessica B.A. Sadler, Jessica B. A. Sadler, Dawn M. Wenzel +10 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Abscission #Biology #Cancer #Cancer research #Cell #Cell biology #Cell cycle #Cell cycle checkpoint #Cell division #Cellular transport and secretion #Chromosome #Chromosome instability #Chromosome segregation #Cytokinesis #DNA #DNA damage #ESCRT #Endosome #G2-M DNA damage checkpoint #Gene #Genetics #Genome instability #Microtubule and mitosis dynamics #Midbody #Mitosis #Renal Diseases and Glomerulopathies
- EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer
2018/09/05 by Hai-Ting Liu, Haiting Liu, Sen Liu +4 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer research #Cancer-related molecular mechanisms research #Cell cycle #Cell cycle progression #Cholangiocarcinoma and Gallbladder Cancer Studies #EGR1 #Gene #Genetics #HNF1A #RNA modifications and cancer #Transcription (linguistics) #Transcription factor
- Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels
2017/03/10 by Michal Sobecki, Karim Mrouj, Jacques Colinge +7 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer #Cancer Genomics and Diagnostics #Cancer cell #Cancer research #Cancer-related Molecular Pathways #Cell #Cell biology #Cell cycle #Cell growth #Cyclin #Cyclin-dependent kinase 6 #Genetic factors in colorectal cancer #Genetics #Immunohistochemistry #Immunology #Ki-67 #Mitosis #Molecular biology
- Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region
2014/12/25 by Sarine Markossian, Subbulakshmi Suresh, Aysha H. Osmani +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Anaphase #Biology #Cell #Cell biology #Cell cycle #Chromatin #DNA #Gene #Genetics #Genomics and Chromatin Dynamics #Interphase #Meiosis #Microtubule and mitosis dynamics #Mitosis #Mitotic exit #Polo-like kinase #Prophase #Ubiquitin and proteasome pathways
- Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process
2014/11/27 by B. Ian Hutchins, Susan Wray · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Microtubule and mitosis dynamics #Cellular Mechanics and Interactions #Cellular transport and secretion #Microtubule #Cell biology #Biology #Cytoskeleton #Neuroscience #Cell migration #Microtubule organizing center #Actin #Cell #Centrosome #Genetics #Cell cycle
- Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
2014/05/29 by Anil Narasimha, Manuel Kaulich, Gary S. Shapiro +3 · 3 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biochemistry #Biology #Cancer Genomics and Diagnostics #Cancer research #Cancer-related Molecular Pathways #Cell #Cell biology #Cell cycle #Chemistry #Cyclin #Cyclin A #Cyclin A2 #Cyclin D #Cyclin D1 #Cyclin E #Cyclin-dependent kinase #Cyclin-dependent kinase 2 #Cyclin-dependent kinase complex #E2F #Epigenetics and DNA Methylation #Molecular biology #Phosphorylation #Protein kinase A
- CP110 exhibits novel regulatory activities during centriole assembly in Drosophila
2013/12/02 by Anna Franz, Hélio Roque, Saroj Saurya +2 · 28 citations
Biochemistry, Genetics and Molecular Biology · #Basal body #Biology #Cell #Cell biology #Cell cycle #Cell division #Centriole #Centrosome #Ciliogenesis #Cilium #Flagellum #Gene #Genetic and Kidney Cyst Diseases #Genetics #Microtubule #Microtubule and mitosis dynamics #Nuclear Structure and Function
- TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity
2013/12/01 by Shafat Ali, Muneeb U. Rehman, Ali Mohd Yatoo +7 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Bone Metabolism and Diseases #Cancer #Cancer cell #Cancer research #Carcinogenesis #Cell biology #Cell cycle #Connective Tissue Growth Factor Research #Epidermal growth factor receptor #Metastasis #NF-κB Signaling Pathways #Oncogene #Pancreatic and Hepatic Oncology Research #R-SMAD #SMAD #Signal transduction #Stromal cell #TGF alpha #TGF-β signaling in diseases #Transforming growth factor
- Feedforward Regulation Ensures Stability and Rapid Reversibility of a Cellular State
2013/05/16 by Andreas Doncic, Jan M. Skotheim, Jan M. Skotheim · 1 citation
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Biology #Bistability #Cell #Cell biology #Cell cycle #Cell cycle checkpoint #Extracellular #Feed forward #Feedback regulation #Fungal and yeast genetics research #Gene #Gene Regulatory Network Analysis #Gene expression #Gene regulatory network #Genetics #Negative feedback #Positive feedback #Signal transduction
- The Cell Cycle is a Limit Cycle
2012/01/01 by Claude Gérard, Albert Goldbeter · 1 citation
Biochemistry, Genetics and Molecular Biology · Mathematics · #Gene Regulatory Network Analysis #Microtubule and mitosis dynamics #Protein Structure and Dynamics #Cyclin-dependent kinase #Cell cycle #Limit cycle #Cyclin #Biological system #Kinetics #Mathematics #Computer science #Limit (mathematics) #Biology #Cell #Physics #Biochemistry #Mathematical analysis
- PR-domain–containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function
2011/06/11 by Yi Zhang, Sandra Stehling-Sun, Kimberly Lezon-Geyda +7 · 25 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Acute Myeloid Leukemia Research #Biology #Cancer research #Cell biology #Cell cycle #Epigenetics and DNA Methylation #Gene #Gene silencing #Genetics #Haematopoiesis #Hematopoietic stem cell #Immune Cell Function and Interaction #Regulator #Stem cell
- Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly
2010/10/18 by Moe R. Mahjoub, Zhigang Xie, Tim Stearns · 28 citations
Biochemistry, Genetics and Molecular Biology · #Basal body #Biology #Cell #Cell biology #Cell cycle #Cell division #Centriole #Centrosome #Cilium #Flagellum #Gene #Genetic and Kidney Cyst Diseases #Genetics #Microtubule #Microtubule and mitosis dynamics #Mitochondrial Function and Pathology
- Centriole symmetry: A big tale from small organisms
2009/09/10 by Maria Giovanna Riparbelli, Romano Dallai, David Mercati +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Microtubule and mitosis dynamics #Genetic and Kidney Cyst Diseases #Protist diversity and phylogeny #Centriole #Biology #Centrosome #Flagellum #Axoneme #Microtubule #Cell biology #Basal body #Cilium #Organelle #Microtubule organizing center #Mitosis #Genetics #Cell #Cell cycle
- PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
2009/04/08 by Ming Zhang, Rong Xie, Wei Hou +7 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Bone Metabolism and Diseases #Bone health and treatments #Cancer research #Cell #Cell biology #Cell cycle #Cyclin A #Cyclin D #Cyclin D1 #Cyclin-dependent kinase #Gene #Gene expression #MG132 #Molecular biology #NF-κB Signaling Pathways #Phosphorylation #Proteasome #Proteasome inhibitor #RUNX2
- DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
2008/09/15 by Zhiyong Mao, Michael J. Bozzella, Andrei Seluanov +1 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #CRISPR and Genetic Engineering #Cell #Cell biology #Cell cycle #DNA #DNA Repair Mechanisms #DNA damage #DNA mismatch repair #DNA repair #DNA-binding protein #Gene #Genetics #Genome instability #Homologous recombination #Homology directed repair #Ku80 #Molecular biology #Non-homologous end joining #PARP inhibition in cancer therapy #Somatic cell
- Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008/07/24 by Deborah L. Burkhart, Julien Sage · 5 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer research #Cancer-related Molecular Pathways #Carcinogenesis #Cell cycle #Gene #Genetics #Ocular Oncology and Treatments #Retinoblastoma #Retinoblastoma protein #Suppressor #Tumor suppressor gene #Ubiquitin and proteasome pathways
- The cell cycle and Toxoplasma gondii cell division: Tightly knit or loosely stitched?
2008/07/25 by Marc-Jan Gubbels, Marc‐Jan Gubbels, Michael W. White +2 · 25 citations
Immunology and Microbiology · Medicine · #Biology #Cell #Cell biology #Cell cycle #Cell division #Cytomegalovirus and herpesvirus research #Cytoplasm #Division (mathematics) #Genetics #Herpesvirus Infections and Treatments #Immunology #Toxoplasma gondii #Toxoplasma gondii Research Studies
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