- Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
2025/09/13 by Sarah K. Walker, Joris van der Veeken, Alexander Y. Rudensky +1 · 1 voice · 1 citation
Immunology and Microbiology · Medicine · #CD8 #Cytomegalovirus and herpesvirus research #Cytotoxic T cell #Immune Cell Function and Interaction #Immune system #Immunotherapy #Population #Progenitor cell #Regulatory T cell #T cell #T-cell and B-cell Immunology
- De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
2025/07/24 by K. Johansen, Darian S. Wolff, Beatrice Scapolo +24 · 1 voice · 16 citations
Chemistry · Immunology and Microbiology · Medicine · #Antigen #Biochemistry #Biology #CAR-T cell therapy research #CD8 #Cancer immunotherapy #Cell biology #Chemistry #Computational biology #Cytotoxic T cell #Cytotoxicity #Gene #Human leukocyte antigen #Immune system #Immunology #Immunotherapy #Immunotherapy and Immune Responses #In silico #In vitro #Major histocompatibility complex #Panning (audio) #Streptamer #T cell #T-cell and B-cell Immunology #T-cell receptor
- Daratumumab in pediatric relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma: the DELPHINUS study
2024/08/19 by Teena Bhatla, Laura E. Hogan, Laura Hogan +32 · 17 citations
Medicine · #Acute Lymphoblastic Leukemia research #Acute lymphocytic leukemia #Childhood Cancer Survivors' Quality of Life #Chronic Myeloid Leukemia Treatments #Daratumumab #Gastroenterology #Hematopoietic stem cell transplantation #Immune system #Immunology #Internal medicine #Lenalidomide #Leukemia #Lymphoblastic Leukemia #Lymphoblastic lymphoma #Lymphoma #Medicine #Minimal residual disease #Multiple myeloma #Oncology #T cell #Transplantation
- The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program
2024/06/18 by Oliver T. Burton, Orian Bricard, Samar Tareen +15 · 2 voices · 32 citations
Immunology and Microbiology · Medicine · #Atherosclerosis and Cardiovascular Diseases #Biology #Cell #Cell biology #FOXP3 #Gene #Genetics #Homing (biology) #IL-2 receptor #Immune Cell Function and Interaction #Immune system #Immunology #Lymphatic system #Medicine #Phenotype #Population #Regulatory T cell #T cell #T-cell and B-cell Immunology #T-cell receptor
- Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants
2024/04/09 by Matthias Bruhn, Maureen Obara, Md. Abdus Salam +10 · 10 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Antigen-presenting cell #B cell #BCL6 #Biology #Gene #Genetics #Germinal center #Immune system #Immunoglobulin class switching #Immunology #Memory B cell #Naive B cell #SARS-CoV-2 and COVID-19 Research #Single-cell and spatial transcriptomics #Somatic hypermutation #T cell #T-cell and B-cell Immunology #Virology #Virus
- Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors
2023/10/24 by Xiuxiu Zhu, Jun Chen, Wuling Li +8 · 27 citations
Chemistry · Immunology and Microbiology · Medicine · #Biochemistry #Biology #CAR-T cell therapy research #Cancer research #Cell #Cell biology #Cell growth #Chemistry #Chimeric antigen receptor #Cytotoxic T cell #Downregulation and upregulation #Hypoxia (environmental) #Immune Cell Function and Interaction #Immune system #Immunology #In vitro #Monoclonal and Polyclonal Antibodies Research #Oxygen #Reprogramming #T cell #Tumor cells #Tumor microenvironment
- Impact of delayed PBMC processing on functional and genomic assays
2023/06/21 by Ping-Cheng Yi, Luting Zhuo, Julie Lin +3 · 15 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Andrology #Biochemistry #Biology #Dendritic cell #ELISPOT #Ex vivo #Flow cytometry #Immune Cell Function and Interaction #Immune system #Immunology #Immunophenotyping #In vitro #Medicine #Molecular biology #Peripheral blood mononuclear cell #Single-cell and spatial transcriptomics #T cell #T-cell and B-cell Immunology #Whole blood
- O -GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation
2023/03/21 by Qiang Zhu, Hongxing Wang, Siyuan Chai +4 · 28 citations
Chemistry · Immunology and Microbiology · Medicine · #Biology #Cancer research #Cell biology #Chemistry #Chronic Lymphocytic Leukemia Research #Immune Cell Function and Interaction #Immune checkpoint #Immune system #Immunology #Immunotherapy #Immunotherapy and Immune Responses #Intracellular #PD-L1 #T cell
- Acidity‐mediated induction of FoxP3 + regulatory T cells
2023/02/14 by Disha Rao, Johanna A. Stunnenberg, Ruben Lacroix +9 · 19 citations
Immunology and Microbiology · #Bacteria #Biochemistry #Biology #Cancer research #Cell biology #Effector #Extracellular #FOXP3 #Glycolysis #IL-2 receptor #Immune Cell Function and Interaction #Immune cells in cancer #Immune system #Immunology #In vivo #Lactic acid #Metabolism #Regulatory T cell #T cell #T-cell and B-cell Immunology #Tumor microenvironment
- Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
2022/06/15 by Kevin M. Sullivan, Kevin M Sullivan, Xiuyun Jiang +33 · 26 citations
Medicine · #Antigen #Biology #CAR-T cell therapy research #CD8 #Cancer Cells and Metastasis #Cancer Immunotherapy and Biomarkers #Cancer research #Immune system #Immunology #T cell
- IL‐13 in dermal type‐2 dendritic cell specialization: From function to therapeutic targeting
2022/06/02 by Olivier Lamiable, Maia Brewerton, Franca Ronchese · 8 citations
Immunology and Microbiology · Medicine · #Acquired immune system #Antigen #Antigen presentation #Antigen-presenting cell #Biology #Cell #Cell biology #Cell type #Dendritic cell #Dermatology and Skin Diseases #Immune Cell Function and Interaction #Immune system #Immunology #Immunotherapy and Immune Responses #Innate lymphoid cell #T cell
- SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron
2022/01/02 by Syed Faraz Ahmed, Ahmed Abdul Quadeer, Matthew R. McKay · 2 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Biology #Cell #Coronavirus disease 2019 (COVID-19) #Disease #Epitope #Genetics #Immune system #Immunology #Immunotherapy and Immune Responses #Infectious disease (medical specialty) #Medicine #SARS-CoV-2 and COVID-19 Research #Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) #T cell #Virology #vaccines and immunoinformatics approaches
- Evidence of immunogenic cancer cell death induced by honey-processed Astragalus polysaccharides in vitro and in vivo
2021/11/23 by Xinrui Sha, Xia Xu, Shuangye Liao +3 · 14 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Biochemistry #Biology #CD40 #CD8 #CD80 #CD86 #Cell biology #Cell cycle #Cell growth #Cytotoxic T cell #Flow cytometry #Immune system #Immunogenic cell death #Immunology #In vitro #Major histocompatibility complex #Metabolomics and Mass Spectrometry Studies #Molecular biology #Programmed cell death #T cell #Tea Polyphenols and Effects #Traditional Chinese Medicine Analysis
- Disruption of adenosine 2A receptor improves the anti-tumor function of anti-mesothelin CAR T cells both in vitro and in vivo
2021/10/19 by Guodi Liu, Qian Zhang, Guoping Liu +7 · 20 citations
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Antigen #Biology #CAR-T cell therapy research #Cancer #Cancer cell #Cancer research #Chimeric antigen receptor #Immune system #Immunology #Mesothelin #Ovarian cancer #Silicon Carbide Semiconductor Technologies #T cell #Tumor microenvironment #Virus-based gene therapy research
- JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy
2021/08/24 by Joseph M. McGraw, Flavian Thelen, Eric Hampton +4 · 1 citation
Immunology and Microbiology · Medicine · #Biology #Blockade #CAR-T cell therapy research #CD8 #Cancer Immunotherapy and Biomarkers #Cancer immunotherapy #Cancer research #Cytotoxic T cell #Immune Cell Function and Interaction #Immune checkpoint #Immune system #Immunity #Immunology #Immunotherapy #In vitro #Receptor #T cell #Tumor-infiltrating lymphocytes
- CAR T cells: Building on the CD19 paradigm
2021/07/02 by Anat Globerson Levin, Isabelle Rivière, Zelig Eshhar +1 · 25 citations
Engineering · Immunology and Microbiology · Medicine · #Antigen #Biology #CAR-T cell therapy research #CD19 #Cancer immunotherapy #Cell biology #Chimeric antigen receptor #Immune Cell Function and Interaction #Immune system #Immunology #Immunotherapy #Major histocompatibility complex #Nanowire Synthesis and Applications #T cell
- Targeting of the Tec Kinase ITK Drives Resolution of T Cell–Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis
2021/07/03 by Kristina Lechner, Stefanie Mott, Ragheed Al-Saifi +14 · 13 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer research #Colitis #Cytokine #Disease #Immune system #Immunology #Inflammatory bowel disease #Internal medicine #Medicine #Melanoma and MAPK Pathways #NF-κB Signaling Pathways #Signaling Pathways in Disease #T cell #Ulcerative colitis
- Platelet MHC class I mediates CD8+ T-cell suppression during sepsis
2021/04/25 by Li Guo, Sikui Shen, Jesse W. Rowley +18 · 25 citations
Immunology and Microbiology · Medicine · #Antigen #Antigen presentation #Biochemistry #Biology #CD8 #Complement system in diseases #Cytotoxic T cell #Immune Cell Function and Interaction #Immune system #Immunology #In vitro #MHC class I #Major histocompatibility complex #Platelet #Platelet Disorders and Treatments #T cell
- Targeting the Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers
2021/03/31 by Liudmila L. Kodach, Maikel P. Peppelenbosch · 1 citation
Immunology and Microbiology · Medicine · #Blockade #Cancer #Cancer cell #Cancer research #Carcinogenesis #Gastric Cancer Management and Outcomes #Gastrointestinal Tumor Research and Treatment #Immune cells in cancer #Immune checkpoint #Immune system #Immunology #Internal medicine #Medicine #Myeloid-derived Suppressor Cell #Oncology #Receptor #Suppressor #T cell
- Macrophage-Based Approaches for Cancer Immunotherapy
2020/11/17 by Nicholas R. Anderson, Nicholas G. Minutolo, Saar Gill +1 · 30 citations
Immunology and Microbiology · Medicine · #Adoptive cell transfer #Biology #CAR-T cell therapy research #Cancer #Cancer immunotherapy #Cancer research #Chimeric antigen receptor #Effector #Immune cells in cancer #Immune system #Immunology #Immunotherapy #In vitro #Internal medicine #Macrophage #Medicine #Phagocytosis and Immune Regulation #T cell
- Results from Lummicar-2: A Phase 1b/2 Study of Fully Human B-Cell Maturation Antigen-Specific CAR T Cells (CT053) in Patients with Relapsed and/or Refractory Multiple Myeloma
2020/11/04 by Shaji K. Kumar, Shaji Kumar, Rachid Baz +13 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antigen #Biology #CAR-T cell therapy research #Cancer research #Chimeric antigen receptor #Immune system #Immunology #Insect Resistance and Genetics #Internal medicine #Lenalidomide #Medicine #Multiple Myeloma Research and Treatments #Multiple myeloma #Refractory (planetary science) #T cell
- Interleukin‐6‐mediated resistance to immunotherapy is linked to impaired myeloid cell function
2020/09/02 by Elham Beyranvand Nejad, Camilla Labrie, Tetje C. van der Sluis +6 · 11 citations
Immunology and Microbiology · Medicine · #Biology #Cancer research #Cytokine Signaling Pathways and Interactions #Immune cells in cancer #Immune system #Immunology #Immunotherapy #Immunotherapy and Immune Responses #MHC class I #Major histocompatibility complex #Medicine #Myeloid #Myeloid leukemia #T cell #Tumor microenvironment
- Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID‐19 patients with pneumonia
2020/07/24 by Sara De Biasi, Domenico Lo Tartaro, Marianna Meschiari +18 · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibody #Antigen #Antigen-presenting cell #B cell #Biology #COVID-19 Clinical Research Studies #Diabetes and associated disorders #Flow cytometry #Humoral immunity #Immune system #Immunoglobulin G #Immunoglobulin M #Immunology #Internal medicine #Medicine #Memory B cell #Naive B cell #Pneumonia #SARS-CoV-2 and COVID-19 Research #T cell
- Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes
2020/01/05 by Diana Y. Chen, David Wolski, Jasneet Aneja +13 · 26 citations
Immunology and Microbiology · Medicine · #Biology #CD8 #Chronic infection #Cytotoxic T cell #Downregulation and upregulation #Hepatitis C virus #Hepatitis C virus research #Immune Cell Function and Interaction #Immune system #Immunology #In vitro #T cell #T-cell and B-cell Immunology #Viremia #Virology #Virus
- Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination
2019/11/07 by M Smits, Maike Smits, Katharina Zoldan +15 · 25 citations
Immunology and Microbiology · Medicine · #Antibody #B cell #Biology #Germinal center #Hepatitis C virus #Hepatitis C virus research #Immune Cell Function and Interaction #Immune system #Immunology #Medicine #Population #T cell #T-cell and B-cell Immunology #Virology #Virus
- Impact of tissue enzymatic digestion on analysis of immune cells in mouse reproductive mucosa with a focus on γδ T cells
2019/09/13 by Katarzyna Skulska, Agnieszka Węgrzyn, Agnieszka S. Wegrzyn +3 · 12 citations
Immunology and Microbiology · Medicine · #Andrology #Biochemistry #Biology #Collagenase #Dispase #Endocrinology #Enzyme #Estrous cycle #Immune Cell Function and Interaction #Immune system #Immunology #Internal medicine #Medicine #Molecular biology #Proteolytic enzymes #Reproductive System and Pregnancy #T cell #T-cell and B-cell Immunology #Uterus
- Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity
2019/03/13 by Yuanyuan Cheng, Mariano Makara, Emma Peel +3 · 1 citation
Medicine · Immunology and Microbiology · #Veterinary Oncology Research #Microbial infections and disease research #T-cell and B-cell Immunology #Repertoire #Biology #T-cell receptor #Immunity #Disease #Immunology #Cancer #Evolutionary biology #Immune system #T cell #Genetics #Medicine #Pathology
- Evolution of chimeric antigen receptor (CAR) T cell therapy: current status and future perspectives
2019/03/04 by Young-Ho Lee, Chan Hyuk Kim · 1 citation
Engineering · Medicine · #Advancements in Semiconductor Devices and Circuit Design #Antigen #Bioinformatics #Biology #CAR-T cell therapy research #CD19 #Cancer research #Cell #Cell therapy #Chimeric antigen receptor #Food and drug administration #Genetics #Immune system #Immunology #Medicine #Nanowire Synthesis and Applications #Pharmacology #T cell
- T cell receptor–triggered nuclear actin network formation drives CD4 + T cell effector functions
2019/01/04 by Nikolaos Tsopoulidis, Sheetal Kaw, Vibor Laketa +5 · 2 citations
Immunology and Microbiology · Medicine · Neuroscience · Chemistry · #T-cell and B-cell Immunology #CAR-T cell therapy research #Neuroinflammation and Neurodegeneration Mechanisms #Cell biology #Actin #Effector #Cell #T cell #Biology #Chemistry #Immunology #Biochemistry #Immune system
- ID2 and ID3 are indispensable for Th1 cell differentiation during influenza virus infection in mice
2018/12/22 by Xiaojuan Han, Hongtao Liu, Huarong Huang +5 · 11 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Antigen #Biology #CD8 #Cell #Cell biology #Cellular differentiation #Cytotoxic T cell #Diabetes and associated disorders #Effector #Gene #Genetics #Immune Cell Function and Interaction #Immune system #Immunology #In vitro #T cell #T-cell and B-cell Immunology
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