The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

2024/06/18 by Oliver T. Burton, Orian Bricard, Samar Tareen +15 · 2 voices · 32 citations
Immunology and Microbiology · #T-cell and B-cell Immunology #Immune Cell Function and Interaction #Atherosclerosis and Cardiovascular Diseases

paper · pdf · doi:10.1016/j.immuni.2024.05.023

Abstract

regulatory T (Treg) cells in non-lymphoid tissues with unique characteristics compared with lymphoid Treg cells. However, tissue Treg cells have not been considered holistically across tissues. Here, we performed a systematic analysis of the Treg cell population residing in non-lymphoid organs throughout the body, revealing shared phenotypes, transient residency, and common molecular dependencies. Tissue Treg cells from different non-lymphoid organs shared T cell receptor (TCR) sequences, with functional capacity to drive multi-tissue Treg cell entry and were tissue-agnostic on tissue homing. Together, these results demonstrate that the tissue-resident Treg cell pool in most non-lymphoid organs, other than the gut, is largely constituted by broadly self-reactive Treg cells, characterized by transient multi-tissue migration. This work suggests common regulatory mechanisms may allow pan-tissue Treg cells to safeguard homeostasis across the body.

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Discussions

• Scientists have discovered that a type of white blood cell exists as a single large population of cells that move throughout the body looking for, and repairing, damaged tissue | Discovery of ‘new rul [lemmy, 70 points, 0 comments]
• Interesting! I wonder if these TCRs share identical nt sequences or if they are examples of convergent recombination positively selected against the same antigen(s). Adrian Liston reported shared Tre [bsky, 4 points, 0 comments]

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