- Latent endogenous viral elements drive active infection and inheritance in a multicellular host
2025/09/15 by Carole Duchêne, Rory J. Craig, Cláudia Martinho +7 · 1 voice · 3 citations
Agricultural and Biological Sciences · Environmental Science · #Animal Disease Management and Epidemiology #Bacteriophages and microbial interactions #Gene #Genome #Giant Virus #Host (biology) #Inheritance (genetic algorithm) #Multicellular organism #Suppressor
- Targeting the Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers
2021/03/31 by Liudmila L. Kodach, Maikel P. Peppelenbosch · 1 citation
Immunology and Microbiology · Medicine · #Blockade #Cancer #Cancer cell #Cancer research #Carcinogenesis #Gastric Cancer Management and Outcomes #Gastrointestinal Tumor Research and Treatment #Immune cells in cancer #Immune checkpoint #Immune system #Immunology #Internal medicine #Medicine #Myeloid-derived Suppressor Cell #Oncology #Receptor #Suppressor #T cell
- The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells
2020/01/30 by Hua Yang, Shengyan Xiang, Aslamuzzaman Kazi +2 · 17 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Antioxidant #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cell biology #Chemistry #Colorectal cancer #Free Radicals and Antioxidants #GTPase #Genetics #Genomics, phytochemicals, and oxidative stress #Glutathione Transferases and Polymorphisms #KRAS #Signal transduction #Small GTPase #Suppressor
- β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells
2019/09/30 by Hemn Mohammadpour, Cameron R. MacDonald, Guanxi Qiao +6 · 36 citations
Chemistry · Medicine · Neuroscience · #Biology #Cancer research #Cancer, Stress, Anesthesia, and Immune Response #Cell biology #Chemistry #Chemokine receptors and signaling #Gene #Genetics #Immunology #Internal medicine #Medicine #Myeloid #Neuropeptides and Animal Physiology #Receptor #Signal transduction #Suppressor
- Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity
2018/10/22 by Hui-Ming Chen, Huiming Chen, William van der Touw +27 · 28 citations
Immunology and Microbiology · #Biology #Cancer #Cancer research #Cell biology #Galectins and Cancer Biology #Immune Cell Function and Interaction #Immune cells in cancer #Immune checkpoint #Immune system #Immunology #Immunotherapy #Inflammation #Myeloid #Myeloid-derived Suppressor Cell #Proinflammatory cytokine #Suppressor #Tumor microenvironment
- KDM5 demethylases and their role in cancer cell chemoresistance
2018/09/24 by Johana Plch, Jan Hrabeta, Jan Hraběta +2 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer epigenetics #Cancer research #Cancer-related gene regulation #DNA methylation #Downregulation and upregulation #Epigenetics #Epigenetics and DNA Methylation #Gene #Gene expression #Genetics #Histone #Histone Deacetylase Inhibitors Research #Histone methylation #Histone methyltransferase #Medicine #Methylation #Population #Suppressor
- Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development
2017/09/08 by Christine Dethlefsen, Louise Hansen, Louise S. Hansen +9 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Breast cancer #Cancer #Cancer research #Hippo pathway signaling and YAP/TAZ #Hippo signaling pathway #Immunology #Internal medicine #Medicine #Oncology #Suppressor
- Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment
2015/11/02 by Peng Qu, Li-zhen Wang, Lizhen Wang +1 · 2 citations
Immunology and Microbiology · Medicine · #Angiogenesis #Biology #Cancer #Cancer research #Immune Response and Inflammation #Immune cells in cancer #Immune system #Immunology #Inflammation biomarkers and pathways #Internal medicine #Medicine #Metastasis #Myeloid #Myeloid cells #Myeloid-derived Suppressor Cell #Suppressor #Tumor cells #Tumor microenvironment #Tumor progression
- Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
2015/08/31 by Stefano Ugel, Francesco De Sanctis, Susanna Mandruzzato +1 · 30 citations
Immunology and Microbiology · Medicine · #Angiogenesis #Biology #Cancer #Cancer Cells and Metastasis #Cancer Immunotherapy and Biomarkers #Cancer research #Cell biology #Haematopoiesis #Immune cells in cancer #Immunology #Metastasis #Myeloid #Myeloid-derived Suppressor Cell #Myelopoiesis #Stem cell #Stromal cell #Suppressor #Tumor cells #Tumor microenvironment #Tumor progression
- Inhibition of B Lymphopoiesis by Adipocytes and IL-1–Producing Myeloid-Derived Suppressor Cells
2015/08/13 by Domenick E. Kennedy, Domenick E Kennedy, Katherine L. Knight +1 · 26 citations
Chemistry · Immunology and Microbiology · #Adipocyte #Adipose tissue #Arginase #Biochemistry #Biology #Bone marrow #Cancer research #Cell biology #Chemistry #Endocrinology #Haematopoiesis #Immune Cell Function and Interaction #Immune cells in cancer #Immunology #Inflammation biomarkers and pathways #Lymphopoiesis #Myeloid #Myeloid-derived Suppressor Cell #Myelopoiesis #Stem cell #Stromal cell #Suppressor
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
2014/04/28 by Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji +6 · 38 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Biology #Blockade #CD40 #CD80 #CD86 #Cancer #Cancer research #Cancer, Hypoxia, and Metabolism #Chemistry #Cytotoxic T cell #Hypoxia (environmental) #Immune Cell Function and Interaction #Immune cells in cancer #Immune checkpoint #Immune system #Immunology #Immunotherapy #In vitro #Internal medicine #Medicine #Myeloid-derived Suppressor Cell #Receptor #Suppressor #T cell #Tumor hypoxia #Tumor microenvironment
- MicroRNA‐30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2
2013/11/29 by Wen‐Ting Liao, Wenting Liao, Y. Ye +18 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Biology #Cancer #Cancer research #Cancer-related molecular mechanisms research #Cell cycle #Cell growth #Colorectal cancer #Gene #Genetics #Immunology #Internal medicine #KRAS #Medicine #MicroRNA in disease regulation #Oncogene #Pathogenesis #RNA Research and Splicing #Suppressor #microRNA
- PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma
2013/09/05 by Michela Boi, Andrea Rinaldi, Ivo Kwee +29 · 27 citations
Immunology and Microbiology · Medicine · #Anaplastic large-cell lymphoma #Anaplastic lymphoma kinase #Biology #Cancer research #Gene #Genetics #Immunology #Lymphoma #Lymphoma Diagnosis and Treatment #Medicine #Pathology #Suppressor #T-cell and Retrovirus Studies #Viral-associated cancers and disorders
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
2013/07/02 by Zaheed Husain, Yannu Huang, Pankaj Seth +2 · 31 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Biochemistry #Biology #Cancer research #Cancer, Hypoxia, and Metabolism #Chemistry #Gene #Immune Cell Function and Interaction #Immune cells in cancer #Immune system #Immunology #Myeloid #Myeloid cells #Myeloid-derived Suppressor Cell #Suppressor #Tumor cells
- Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
2013/03/07 by Marco A. Briones‐Orta, Marco A. Briones-Orta, Laurence Lévy +6 · 21 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer Cells and Metastasis #Cancer research #Carcinogenesis #Cell biology #Cell culture #Developmental Biology and Gene Regulation #Gene knockdown #Genetics #Metastasis #Suppressor #TGF-β signaling in diseases #Transforming growth factor #Tumor progression
- Regulation of Foxp3+ Inducible Regulatory T Cell Stability by SOCS2
2013/03/02 by Camille Knosp, Camille A Knosp, Chris Schiering +21 · 23 citations
Chemistry · Immunology and Microbiology · Medicine · #Biology #Cell biology #Chemistry #Cytokine Signaling Pathways and Interactions #FOXP3 #Gene #Genetics #IL-2 receptor #Immune Cell Function and Interaction #Immune system #Regulatory T cell #SOCS2 #Suppressor #T cell #T-cell and B-cell Immunology
- IL‐1β regulates a novel myeloid‐derived suppressor cell subset that impairs NK cell development and function
2010/11/25 by Moshe Elkabets, Vera S. G. Ribeiro, Charles A. Dinarello +4 · 30 citations
Immunology and Microbiology · #Biology #Cancer #Cancer research #FOXP3 #Immune Cell Function and Interaction #Immune cells in cancer #Immune system #Immunology #Inflammation #Inflammation biomarkers and pathways #Myeloid #Myeloid-derived Suppressor Cell #Suppressor #T cell #Tumor microenvironment #Tumor progression
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
2010/09/27 by Cesar A. Corzo, Thomas Condamine, Lily Lu +11 · 39 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Biology #Cancer #Cancer research #Cancer, Hypoxia, and Metabolism #Cell biology #Chemistry #Immune Response and Inflammation #Immune cells in cancer #Immune system #Immunology #Myeloid #Myeloid-derived Suppressor Cell #Suppressor #Tumor microenvironment
- Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma
2010/04/20 by Bethany E. Schaffer, Kwon-Sik Park, Gloria Yiu +7 · 28 citations
Medicine · #Biology #Cancer research #Carcinogenesis #Carcinoma #Gene #Genetics #Internal medicine #Knockout mouse #Lung #Lung Cancer Research Studies #Lung cancer #Medicine #Mutant #Neuroendocrine Tumor Research Advances #Pathology #Peptidase Inhibition and Analysis #Small Cell Lung Carcinoma #Small-cell carcinoma #Suppressor #Tumor suppressor gene
- Actin-Based Protrusions: Promoters or Inhibitors of Cancer Invasion?
2009/07/01 by Laura M. Machesky, Hao Ran Tang, Hao Tang · 1 citation
Biochemistry, Genetics and Molecular Biology · #Actin #Actin cytoskeleton #Biology #Cancer #Cancer cell #Cancer research #Carcinogenesis #Cell #Cell biology #Cellular Mechanics and Interactions #Cytoskeleton #Gene #Genetics #Microtubule and mitosis dynamics #RNA Research and Splicing #Suppressor #Tumor progression #Tumor suppressor gene
- Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008/07/24 by Deborah L. Burkhart, Julien Sage · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cancer #Cancer research #Cancer-related Molecular Pathways #Carcinogenesis #Cell cycle #Gene #Genetics #Ocular Oncology and Treatments #Retinoblastoma #Retinoblastoma protein #Suppressor #Tumor suppressor gene #Ubiquitin and proteasome pathways
- Inflammation and cancer: An ancient link with novel potentials
2007/09/24 by S. Perwez Hussain, Curtis C. Harris · 30 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Biology #Cancer #Cancer research #Cancer-related molecular mechanisms research #Carcinogenesis #DNA methylation #Epigenetics #Gene #Gene expression #Genetics #Immune cells in cancer #Immune system #Immunity #Immunology #Inflammation #Innate immune system #MicroRNA in disease regulation #Suppressor #microRNA
- Kinetic Computational Alanine Scanning: Application to p53 Oligomerization
2006/01/18 by Lillian T. Chong, William C. Swope, Jed W. Pitera +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alanine #Alanine scanning #Amino acid #Biochemistry #Biology #Biophysics #Cancer-related Molecular Pathways #Chemistry #Computational biology #Epigenetics and DNA Methylation #Gene #Genomics and Chromatin Dynamics #Kinetics #Mutagenesis #Mutation #P53 protein #Physics #Protein stability #Suppressor #Transition (genetics)
- Apoptosis and cancer chemotherapy
2000/03/23 by Guy Makin, John A. Hickman · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Bioinformatics #Biology #Cancer #Cancer cell #Cancer research #Cancer-related Molecular Pathways #Cell #Cell biology #Cell death mechanisms and regulation #Chemotherapeutic drugs #Drug #Drug resistance #Effector #Gene #Genetics #Mechanism (biology) #PARP inhibition in cancer therapy #Pharmacology #Programmed cell death #Suppressor
- Influences on Anglo-French relations, 1814-1818
1997/01/01 by Mary T Duarte, Hyo Rim Ko, Yun Sil Chang +2 · 16 citations
Arts and Humanities · Biochemistry, Genetics and Molecular Biology · Medicine · #Binding protein #Biochemical and Molecular Research #Biochemistry #Biology #Cancer-related Molecular Pathways #Carcinogenesis #Cell biology #ERBB3 #European Political History Analysis #Gene #Gene isoform #Historical Studies and Socio-cultural Analysis #History #Linguistics #PI3K/AKT/mTOR pathway #Peptidase Inhibition and Analysis #Philosophy #Phosphorylation #Political science #Protein kinase B #Receptor tyrosine kinase #Signal transduction #Suppressor
- SYTL4 acts as a tumor suppressor in colorectal cancer by promoting ubiquitination and degradation of SEC31B
2026/07/23 by Li J, Jinlei Li, Xiaodong Zhang +11
Biochemistry, Genetics and Molecular Biology · #Cellular transport and secretion #Colorectal cancer #Deubiquitinating enzyme #Effector #Gene knockdown #Mdm2 #Microtubule and mitosis dynamics #Neddylation #Suppressor #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase