John A. Hickman
- The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
2016/10/01 by András Kotschy, Zoltán Szlavik, Zoltán Szlávik +68 · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cancer-related Molecular Pathways #Cell death mechanisms and regulation #Chemistry #Downregulation and upregulation #Genetics #In vivo #Internal medicine #MCL1 #Medicine #Ubiquitin and proteasome pathways
- S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth
2018/04/13 by Patrick Casara, James Davidson, Audrey Clapéron +35 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Chronic Lymphocytic Leukemia Research #Cell death mechanisms and regulation #Ubiquitin and proteasome pathways
- Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
2014/09/01 by John A. Hickman, Ralph Graeser, Ronald De Hoogt +4 · 1 citation
Engineering · Medicine · Biochemistry, Genetics and Molecular Biology · #3D Printing in Biomedical Research #Cancer Cells and Metastasis #Cellular Mechanics and Interactions
- Membrane targets in cancer chemotherapy
1988/08/01 by J.A. Hickman, John A. Hickman · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer-related Molecular Pathways #DNA and Nucleic Acid Chemistry #Drug Transport and Resistance Mechanisms
- Limits to Personalized Cancer Medicine
2016/09/28 by Ian F. Tannock, John A. Hickman · 2 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Cancer Genomics and Diagnostics #Statistical Methods in Clinical Trials #Lung Cancer Treatments and Mutations
- Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
2004/09/01 by Elizabeth A. Jonas, John A. Hickman, Mushtaque Chachar +9 · 1 citation
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neuroscience and Neuropharmacology Research #Mitochondrial Function and Pathology #Ion channel regulation and function
- Membrane targets in cancer chemotherapy
1984/01/01 by John A. Hickman, Kevin J. Scanlon, Thomas R. Tritton · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Psychology · #Biological Research and Disease Studies #Cancer #Cancer chemotherapy #Chemotherapy #Drug Transport and Resistance Mechanisms #Internal medicine #Medicine #Oncology #Psychology #Psychotherapist
- The European Union and personalised cancer medicine
2021/04/21 by John A. Hickman, Ian F. Tannock, Lydie Meheus +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Bioinformatics #Biology #Business #Cancer #Cancer Genomics and Diagnostics #Economic policy #Engineering #European union #Genetic factors in colorectal cancer #Internal medicine #Limiting #Lung Cancer Treatments and Mutations #Medicine #Pathology #Personalized medicine #Political science #Precision medicine #Risk analysis (engineering)
- Apoptosis and cancer chemotherapy
2000/03/23 by Guy Makin, John A. Hickman · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Bioinformatics #Biology #Cancer #Cancer cell #Cancer research #Cancer-related Molecular Pathways #Cell #Cell biology #Cell death mechanisms and regulation #Chemotherapeutic drugs #Drug #Drug resistance #Effector #Gene #Genetics #Mechanism (biology) #PARP inhibition in cancer therapy #Pharmacology #Programmed cell death #Suppressor
- Apoptosis induced by anticancer drugs
1992/09/01 by John A. Hickman · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #Apoptosis #Biology #Cancer research #Cancer therapeutics and mechanisms #Cell biology #Cell death mechanisms and regulation #Chromatin #Cytotoxic T cell #Cytotoxicity #DNA #DNA damage #Drug #Gene #Genetics #In vitro #Pharmacology #Programmed cell death #Synthesis and biological activity #Topoisomerase