Inflammation and cancer: An ancient link with novel potentials

2007/09/24 by S. Perwez Hussain, Curtis C. Harris · 29 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #MicroRNA in disease regulation #Cancer-related molecular mechanisms research #Immune cells in cancer

paper · pdf · doi:10.1002/ijc.23173

Abstract

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer.

Cited by

• Tumor necrosis: A synergistic consequence of metabolic stress and inflammation
• Modifiable risk factors in periodontitis: at the intersection of aging and disease
• Regulation of hypoxia-inducible factor-1α by NF-κB
• JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance
• Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. [europepmc]
• Luteolin, a flavonoid with potential for cancer prevention and therapy. [europepmc]
• Inflammation: a driving force speeds cancer metastasis. [europepmc]
• MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. [europepmc]
• The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. [europepmc]
• Oxidative stress, inflammation, and cancer: how are they linked? [europepmc]
• Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. [europepmc]
• Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. [europepmc]
• Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. [europepmc]
• Chronic inflammation in cancer development. [europepmc]
• Urinary biomarkers of oxidative status. [europepmc]
• NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. [europepmc]
• Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review. [europepmc]
• Molecular mechanisms underlying chronic inflammation-associated cancers. [europepmc]
• Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes. [europepmc]
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. [europepmc]
• A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2. [europepmc]
• Role of Antioxidants and Natural Products in Inflammation. [europepmc]
• Immunological Approaches Towards Cancer and Inflammation: A Cross Talk. [europepmc]
• Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis. [europepmc]
• Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. [europepmc]
• Inflammation and cancer. [europepmc]
• Role of the NLRP3 inflammasome in cancer. [europepmc]
• The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review. [europepmc]
• The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders. [europepmc]

Related

• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
• Inflammation and tumor progression: signaling pathways and targeted intervention
• Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers
• Genomic instability, inflammatory signaling and response to cancer immunotherapy
• Function and regulation of IL‐1α in inflammatory diseases and cancer