Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence

2020/12/02 by Kristbjorn O. Gudmundsson, Nhu Nguyen, Kevin Oakley +7 · 12 citations
Medicine · Immunology and Microbiology · #Hematopoietic Stem Cell Transplantation #Immune Cell Function and Interaction #T-cell and B-cell Immunology

paper · doi:10.1073/pnas.2017626117

Abstract

Significance Regulation of quiescence is critical for the maintenance of adult HSCs, and the underlying mechanisms are poorly understood. Using a novel mouse conditional knockout allele of transcription factor gene Prdm16 , we show that its deletion in the adult hematopoietic system led to a gradual loss of adult HSCs over time. This loss of adult HSCs was associated with their significantly increased cycling. We further found that Prdm16 promotes the quiescence of adult HSCs by activating the transcription of HSC cell cycle inhibitors including Cdkn1a and Egr1 . Our study identifies Prdm16 as a critical regulator of adult HSC quiescence.

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