Marc Hafner
- Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
2016/05/02 by Marc Hafner, Mario Niepel, Mirra Chung +2 · 3 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Computational Drug Discovery Methods #Genomics and Chromatin Dynamics #Protein Degradation and Inhibitors
- ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer
2025/01/13 by Jackson Liang, Xiaosai Yao, Patrick Aouad +17 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #BRCA gene mutations in cancer #Cancer-related Molecular Pathways #Genomics and Chromatin Dynamics
- Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
2019/06/06 by Marc Hafner, Caitlin E. Mills, Kartik Subramanian +8 · 2 citations
Medicine · #Advanced Breast Cancer Therapies #Biology #Breast cancer #CDK inhibitor #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Computational biology #Cyclin-dependent kinase #Cyclin-dependent kinase 1 #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Genetics #Internal medicine #Kinase #Medicine #Metastatic breast cancer #Palbociclib #Pharmacology #Protein kinase A
- A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines
2019/07/01 by Mario Niepel, Marc Hafner, Caitlin E. Mills +32 · 2 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Cell Image Analysis Techniques #Computational Drug Discovery Methods #Advanced Biosensing Techniques and Applications
- Evaluation of statistical approaches for association testing in noisy drug screening data
2022/05/18 by Petr Smirnov, Ian C. P. Smith, Zhaleh Safikhani +9 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Mathematics · #Genetic Associations and Epidemiology #Statistical Methods and Inference #Statistical Methods in Clinical Trials
- Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
2021/08/28 by Caitlin E. Mills, Kartik Subramanian, Marc Hafner +9 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Medicine · #Advanced Fluorescence Microscopy Techniques #Biochemistry #Bioinformatics #Biology #Biomedical engineering #Cell #Cell Image Analysis Techniques #Chemistry #Computational biology #Computer science #Drop (telecommunication) #Engineering #Flow cytometry #High-content screening #High-throughput screening #Limiting #Materials science #Medicine #Molecular biology #Multiplexing #Nanotechnology #Single-cell and spatial transcriptomics