1. Coumarins link iron deficiency to TOR inhibition in plants
   2026/07/01 by Huikyong Cho, Ilyeong Choi, Sachi Horibata +7 · 2 voices
   Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Arabidopsis #Arabidopsis thaliana #Coumarin #Endogeny #Kinase #Metabolism #Nitrogen and Sulfur Effects on Brassica #PI3K/AKT/mTOR signaling in cancer #Plant nutrient uptake and metabolism #Regulator #Second messenger system #Signal transduction #TOR signaling
2. Inhibitors supercharge kinase turnover through native proteolytic circuits
   2025/11/26 by Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus +27 · 1 voice · 7 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · #ASK1 #Chaperone (clinical) #Chemical biology #Click Chemistry and Applications #Kinase #MAP kinase kinase kinase #Protein Degradation and Inhibitors #Protein degradation #Protein kinase A #Small molecule #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase
3. Negative feedback regulation of the hemi-arrestin MAPK scaffold Sms1 prevents untimely mating
   2025/09/25 by Boris Sieber, Laura Merlini, W. Li +4 · 2 voices · 2 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Kinase #MAPK/ERK pathway #Mitogen-activated protein kinase #Nuclear Receptors and Signaling #Phosphorylation #Protein kinase A #Receptor Mechanisms and Signaling #Renin-Angiotensin System Studies #Scaffold #Scaffold protein #Signal transduction
4. Cysteine-rich receptor-like kinases mediate Wall Teichoic Acid perception in Arabidopsis
   2025/09/21 by Leon Pierdzig, C. Seinsche, Stefan Kalla +7 · 1 voice · 1 citation
   Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Cell wall #Function (biology) #Gene #Kinase #Pathogen-associated molecular pattern #Pattern recognition receptor #Photosynthetic Processes and Mechanisms #Plant Stress Responses and Tolerance #Polysaccharides and Plant Cell Walls #Salicylic acid #Teichoic acid
5. A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration
   2025/08/07 by John W. Quinn, Mariah C. Lee, Chloe Van Hazel +2 · 1 voice · 1 citation
   Immunology and Microbiology · Materials Science · Mathematics · Medicine · #Biology #Cell biology #Effector #Enhancer #Gene #Gene expression #Genetics #Hippo signaling pathway #Invertebrate Immune Response Mechanisms #JAK-STAT signaling pathway #Kinase #Receptor tyrosine kinase #Regeneration (biology) #Signal transduction #Silk-based biomaterials and applications #Wound Healing and Treatments #stat
6. A high-throughput zebrafish screen identifies novel candidate treatments for kaposiform lymphangiomatosis (KLA)
   2025/07/03 by Ivan Bassi, Amani Jabali, Lotan Levin +18 · 3 citations
   Engineering · Medicine · #Biology #Bosutinib #Bruton's tyrosine kinase #CNS Lymphoma Diagnosis and Treatment #Cancer research #Cell biology #Dasatinib #Gene #Genetics #Immunology #Islanding Detection in Power Systems #KRAS #Kinase #Lymphangiomatosis #Lymphatic system #MAPK/ERK pathway #Mutation #Neuroblastoma RAS viral oncogene homolog #Receptor tyrosine kinase #Signal transduction #Trametinib #Tyrosine kinase #Vascular Malformations and Hemangiomas #Zebrafish
7. Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis
   2024/02/12 by Hailin Liu, Lian Zhou, Xifeng Wang +9 · 23 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Biology #Cell biology #Chemistry #Downregulation and upregulation #Endocrinology #Erythrocyte Function and Pathophysiology #Glucocorticoid #Glucocorticoid receptor #Immunology #In vitro #Inflammation #Kinase #Macrophage #Neonatal Health and Biochemistry #Protein kinase B #SGK1 #Signal transduction #Sphingolipid Metabolism and Signaling
8. The V-ATPase–ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response
   2023/12/12 by Tomoya Eguchi, Maria Sakurai, Yingxue Wang +6 · 28 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #AMPK #ATG16L1 #ATG8 #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Calcium signaling and nucleotide metabolism #Cell biology #Cellular transport and secretion #Chemistry #Enzyme #Kinase #LRRK2 #Lipid-anchored protein #Lysosome #Mutation #Protein kinase A #Secretion #ULK1
9. LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway
   2023/05/29 by Jing Zhao, Meini Le, Jie Li +14 · 16 citations
   Biochemistry, Genetics and Molecular Biology · #Apoptosis #Biochemistry #Biology #Cancer-related molecular mechanisms research #Cell biology #Cell culture #Circular RNAs in diseases #Endocrinology #Gene knockdown #Kinase #MAPK/ERK pathway #Neuroblastoma #Neuroprotection #Oxidative stress #Pharmacology #Protein kinase A #RNA modifications and cancer #SH-SY5Y #Signal transduction #p38 mitogen-activated protein kinases
10. Esketamine is neuroprotective against traumatic brain injury through its modulation of autophagy and oxidative stress via AMPK/mTOR-dependent TFEB nuclear translocation
    2023/05/13 by Tang Yanbin, Yanbin Tang, Yufang Liu +5 · 26 citations
    Chemistry · Medicine · Neuroscience · #AMPK #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cannabis and Cannabinoid Research #Cell biology #Chemistry #Internal medicine #Kinase #Medicine #Neuroprotection #Neuroscience #Neuroscience and Neuropharmacology Research #Oxidative stress #PI3K/AKT/mTOR pathway #Protein kinase A #Signal transduction #TFEB
11. Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
    2022/07/10 by Chris Arter, Luke Trask, Sarah Ward +2 · 28 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Allosteric regulation #Biochemistry #Biology #Cell biology #Chemistry #Computational biology #Cyclin-dependent kinase 2 #Enzyme #Gene #Kinase #MAP2K7 #Melanoma and MAPK Pathways #PI3K/AKT/mTOR signaling in cancer #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Protein kinase domain #Structural biology #c-Raf
12. Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice
    2022/03/09 by Krishna C. Penumatsa, A. Singhal, Adit A. Singhal +12 · 3 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biology #Cell biology #Chemistry #Endocrinology #Hypoxia (environmental) #Internal medicine #Kinase #Medicine #Muscle hypertrophy #Oxygen #PI3K/AKT/mTOR signaling in cancer #Pharmacology #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Pulmonary Hypertension Research and Treatments #Pulmonary artery #Pulmonary hypertension #ROCK1 #ROCK2 #Rho-associated protein kinase #Right ventricular hypertrophy #Signal transduction
13. Urolithin A attenuates RANKL-induced osteoclastogenesis by co-regulating the p38 MAPK and Nrf2 signaling pathway
    2022/02/26 by Wei Wei, Chenjian Peng, Renjun Gu +6 · 13 citations
    Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Nursing · #Activator (genetics) #Biochemistry #Biology #Bone Metabolism and Diseases #Bone resorption #Cancer research #Cell biology #Chemistry #Cynara cardunculus studies #Endocrinology #Inflammation #Internal medicine #Kinase #MAPK/ERK pathway #Medicine #NF-κB #Osteoclast #Phosphorylation #Pomegranate: compositions and health benefits #Protein kinase A #RANKL #Receptor #Signal transduction #p38 mitogen-activated protein kinases
14. Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC
    2021/10/19 by Moshe T. Gordon, Brian P. Ziemba, Joseph J. Falke · 8 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · #AKT1 #Biology #Cell biology #Cellular transport and secretion #Chemistry #Kinase #PI3K/AKT/mTOR signaling in cancer #Phosphatidylinositol #Phosphorylation #Protein Kinase Regulation and GTPase Signaling #Protein kinase B #Protein kinase C #Signal transduction
15. Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats
    2021/09/20 by Xiao-Jun Cao, Rui Wu, Heya Qian +9 · 10 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #AMPK #Anatomy #Biochemical effects in animals #Chemistry #Diabetes mellitus #Dorsal root ganglion #Dorsum #Endocrinology #Internal medicine #Kinase #Medicine #Metabolism, Diabetes, and Cancer #Metformin #Neuropathic pain #Pain Mechanisms and Treatments #Pharmacology #Protein kinase A
16. Multiple functions of pyruvate kinase M2 in various cell types
    2021/07/26 by Yoon‐Beom Lee, Jung K. Min, Jung Ki Min +18 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Acetylation #Biochemistry #Biology #Cancer #Cancer cell #Cancer, Hypoxia, and Metabolism #Cell biology #Enzyme #Gene #Genetics #Glycogen Storage Diseases and Myoclonus #Glycolysis #Isozyme #Kinase #Metabolism, Diabetes, and Cancer #PKM2 #Phosphorylation #Protein kinase A #Pyruvate kinase
17. The development of inhibitors of leucine‐rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play
    2021/05/29 by Sonia Azeggagh, Daniel C. Berwick · 17 citations
    Medicine · Neuroscience · #Alzheimer's disease research and treatments #Biology #Cell biology #Current (fluid) #Disease #Internal medicine #Kinase #LRRK2 #Leucine-rich repeat #Medicine #Neuroscience #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pharmacology #Physics
18. Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity
    2021/01/28 by Dianne K. Bryce, C. Ware, Chris M. Ware +16 · 7 citations
    Chemistry · Medicine · Neuroscience · #Amino acid #Biochemistry #Biology #Cell biology #Chemistry #Cholinesterase and Neurodegenerative Diseases #Kinase #Leucine #Nuclear Receptors and Signaling #Parkinson's Disease Mechanisms and Treatments #Pharmacology #Protein kinase A
19. Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy
    2020/11/21 by Yuan Fang, Fang Yuan, Yingying Xu +4 · 9 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #AMPK #ATG5 #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Calcitriol #Cancer research #Cell biology #Chemistry #Endocrinology #Erythrocyte Function and Pathophysiology #Heme Oxygenase-1 and Carbon Monoxide #Hepatocyte #In vitro #Kinase #PI3K/AKT/mTOR pathway #Pharmacology #Protein kinase A #Viability assay #Vitamin D and neurology
20. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
    2020/03/26 by Ryan Choi, Matthew A. Hulverson, Wenlin Huang +27 · 26 citations
    Medicine · Veterinary · #Biology #Cell biology #Computational biology #Helminth infection and control #Kinase #Pharmacology #Research on Leishmaniasis Studies #Trypanosoma species research and implications
21. RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells
    2020/03/12 by Mi Wang, Hao Wan, Shuchao Wang +11 · 23 citations
    Biochemistry, Genetics and Molecular Biology · #Apoptosis #Biochemistry #Biology #Cell biology #Cell death mechanisms and regulation #Hippo pathway signaling and YAP/TAZ #Kinase #Mitochondrial Function and Pathology #Necroptosis #Phosphorylation #Programmed cell death #Regulator #Retinal #Retinal ganglion cell
22. Astragalus polysaccharides alleviates LPS‐induced inflammation via the NF‐κB/MAPK signaling pathway
    2020/02/09 by Na Dong, Xinran Li, Chenyu Xue +4 · 25 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Biochemistry #Biology #Cell biology #Chemokine #Gene #Gene expression #Immune Response and Inflammation #Immune cells in cancer #Immunology #Inflammation #Inflammatory Bowel Disease #IκBα #KEGG #Kinase #Lipopolysaccharide #MAPK/ERK pathway #Molecular biology #NF-κB #Protein kinase A #Signal transduction #Transcriptome #Western blot #p38 mitogen-activated protein kinases
23. Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis
    2020/01/16 by Ahmed B. Alarabi, Zubair A. Karim, Jean E. Montes Ramirez +5 · 1 citation
    Medicine · Neuroscience · #Smoking Behavior and Cessation #Ion Channels and Receptors #Platelet Disorders and Treatments #Hemostasis #Platelet #Medicine #Thrombus #Platelet activation #Thrombosis #Nicotine #Kinase #Immunology #Internal medicine #Cell biology #Biology
24. Stress granules as a feedback mechanism of MAPK signaling by sequestering PKC/Pck2
    2020/01/01 by Yuki Kanda, Ryosuke Satoh, Teruaki Takasaki +8 · 11 citations
    Biochemistry, Genetics and Molecular Biology · #Biochemistry #Biology #Cell #Cell biology #Cell growth #Chromosomal translocation #Cytoplasm #Endoplasmic Reticulum Stress and Disease #Fungal and yeast genetics research #Gene #Heat shock proteins research #Kinase #MAPK/ERK pathway #Mitogen-activated protein kinase #Protein kinase A #Protein kinase C #Signal transduction
25. ERK inhibition effectively overcomes acquired resistance of epidermal growth factor receptor‐mutant non–small cell lung cancer cells to osimertinib
    2019/12/10 by Yiting Li, Hongjing Zang, Guoqing Qian +4 · 25 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer #Cancer research #Cell biology #Cytokine Signaling Pathways and Interactions #Epidermal growth factor #Epidermal growth factor receptor #Erlotinib #Internal medicine #Kinase #Lung Cancer Treatments and Mutations #Lung cancer #MAPK/ERK pathway #Medicine #Melanoma and MAPK Pathways #Mutant #Oncology #Osimertinib #Receptor
26. Neuroprotective effects of DAAO are mediated via the ERK1/2 signaling pathway in a glaucomatous animal model
    2019/12/04 by Xuejin Zhang, Rong Zhang, Junyi Chen +1 · 10 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Amino Acid Enzymes and Metabolism #Apoptosis #Biochemistry #Biology #Cell biology #Chemistry #Glaucoma and retinal disorders #Kinase #MAPK/ERK pathway #Molecular biology #Neuroprotection #Neuroscience #Neuroscience and Neuropharmacology Research #Pharmacology #Phosphorylation #Protein kinase A #Retina #Retinal ganglion cell #Signal transduction #TUNEL assay #p38 mitogen-activated protein kinases
27. Propionate suppresses hepatic gluconeogenesis via GPR43/AMPK signaling pathway
    2019/07/26 by Hiroki Yoshida, Megumi Ishii, Mitsugu Akagawa · 26 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #AMP-activated protein kinase #AMPK #Biochemistry #Biology #Butyrate #Carbohydrate metabolism #Chemistry #Diet, Metabolism, and Disease #Enzyme #Gluconeogenesis #Kinase #Metabolism #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Phosphoenolpyruvate carboxykinase #Propionate #Protein kinase A
28. CSE1L silence inhibits the growth and metastasis in gastric cancer by repressing GPNMB via positively regulating transcription factor MITF
    2019/07/25 by Yijun Li, Shanshan Yuan, Jiaming Liu +4 · 22 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer research #Cell biology #Gene #Kinase #MAPK/ERK pathway #Medicine #MicroRNA in disease regulation #Microphthalmia-associated transcription factor #PI3K/AKT/mTOR pathway #Protein kinase A #Protein kinase B #RNA Research and Splicing #RNA modifications and cancer #Signal transduction #Transcription factor
29. Cadmium activates ZmMPK3-1 and ZmMPK6-1 via induction of reactive oxygen species in maize roots
    2019/06/26 by Yukun Liu, Lixia Liu, Jianhua Qi +2 · 11 citations
    Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Biology #Cadmium #Cell biology #Chemistry #Kinase #MAPK/ERK pathway #Plant Gene Expression Analysis #Plant Stress Responses and Tolerance #Plant-Microbe Interactions and Immunity #Protein kinase A #Reactive oxygen species #Signal transduction
30. Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
    2019/06/06 by Marc Hafner, Caitlin E. Mills, Kartik Subramanian +8 · 2 citations
    Medicine · #Advanced Breast Cancer Therapies #Biology #Breast cancer #CDK inhibitor #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Computational biology #Cyclin-dependent kinase #Cyclin-dependent kinase 1 #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Genetics #Internal medicine #Kinase #Medicine #Metastatic breast cancer #Palbociclib #Pharmacology #Protein kinase A

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