- Inhibitors supercharge kinase turnover through native proteolytic circuits
2025/11/26 by Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus +27 · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #ASK1 #Chaperone (clinical) #Chemical biology #Click Chemistry and Applications #Kinase #MAP kinase kinase kinase #Protein Degradation and Inhibitors #Protein degradation #Protein kinase A #Small molecule #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase
- PKC and PKN in heart disease
2019/02/10 by Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler +4 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ASK1 #Biology #Cardiac electrophysiology and arrhythmias #Cell biology #Internal medicine #Kinase #Medicine #Mitogen-activated protein kinase kinase #P70-S6 Kinase 1 #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Protein kinase B #Protein kinase C #Signal transduction #Signaling Pathways in Disease #c-Raf
- Dickkopf-3 attenuates pressure overload-induced cardiac remodelling
2014/01/09 by Yan Zhang, Yu Liu, Xue‐Hai Zhu +20 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ASK1 #Biochemistry #Biology #Cardiac Fibrosis and Remodeling #Cardiac fibrosis #Cardiac function curve #Cardiac hypertrophy #Cell biology #Conditional gene knockout #Congenital heart defects research #Endocrinology #Fibrosis #Gene #Genetically modified mouse #Heart failure #Internal medicine #Kinase #Medicine #Mitogen-activated protein kinase kinase #Muscle hypertrophy #Phenotype #Pressure overload #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Transgene
- Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy
2002/01/01 by Yasuchika Takeishi, Y Takeishi · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ASK1 #Biology #Cardiac Fibrosis and Remodeling #Cardiac electrophysiology and arrhythmias #Cell biology #Cyclin-dependent kinase 2 #Internal medicine #Kinase #MAP kinase kinase kinase #MAP2K7 #MAPK14 #Medicine #Melanoma and MAPK Pathways #Mitogen-activated protein kinase #Mitogen-activated protein kinase kinase #Protein kinase A #p38 mitogen-activated protein kinases
- JNK3 contributes to c‐Jun activation and apoptosis but not oxidative stress in nerve growth factor‐deprived sympathetic neurons
2001/07/15 by Shane Bruckner, Shane R. Bruckner, Steven P. Tammariello +5 · 11 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #ASK1 #Apoptosis #Biochemistry #Biology #Cell biology #Cell death mechanisms and regulation #Chemistry #Endocrinology #Gene #Gene isoform #Internal medicine #Kinase #Medicine #Melanoma and MAPK Pathways #Mitogen-activated protein kinase kinase #Nerve growth factor #Oxidative stress #Phosphorylation #Programmed cell death #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Receptor #Signal transduction #Transcription factor #c-jun
- NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells
1999/05/01 by Masaaki Awane, M. Awane, Pietro G Andres +4 · 14 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #ASK1 #Biology #Cell biology #Chemistry #Chemokine #Cytokine Signaling Pathways and Interactions #Immunology #Inflammation #Kinase #MAP kinase kinase kinase #Mitogen-activated protein kinase kinase #Molecular biology #Mycobacterium research and diagnosis #NF-κB Signaling Pathways #Protein kinase A #Signal transduction #p38 mitogen-activated protein kinases
- SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis
1998/11/30 by Jacques Huot, François Houle, Simon Rousseau +3 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Heat shock proteins research #Cellular Mechanics and Interactions #Tendon Structure and Treatment #Cell biology #Biology #Hsp27 #Focal adhesion #Bleb (medicine) #MDia1 #ASK1 #Microfilament #Cytochalasin D #Actin remodeling #Actin cytoskeleton #Stress fiber #Cytoskeleton #Protein kinase A #Mitogen-activated protein kinase kinase #Kinase #Heat shock protein #Signal transduction #Biochemistry #Cell #Hsp70