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1. Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis?
   2023/04/04 by David A. Hume, David Hume · 6 citations
   Immunology and Microbiology · Medicine · #Biology #Bone marrow #Cell biology #Cre recombinase #Embryo #Fate mapping #Gene #Genetically modified mouse #Genetics #Haematopoiesis #Immune cells in cancer #Immunology #Macrophage #Mononuclear phagocyte system #Neonatal Respiratory Health Research #Progenitor cell #Reproductive System and Pregnancy #Stem cell #Transgene #Yolk sac
2. Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice
   2023/03/03 by Yi-ying Wang, Yiying Wang, Yu-ning Zhou +16 · 21 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Advanced Glycation End Products research #Alzheimer's disease research and treatments #Biochemistry #Biology #Colocalization #Dendritic spine #Dentate gyrus #Endocrinology #Gene #Genetically modified mouse #Glycation #Hippocampal formation #Hippocampus #Inflammation #Internal medicine #Medicine #Microglia #Neuroinflammation and Neurodegeneration Mechanisms #Neuroscience #Rage (emotion) #Receptor #Synapse #Synapsin I #Transgene
3. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice
   2017/03/18 by Hayk Davtyan, Wesley W. Chen, Karen Zagorski +8 · 17 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Alzheimer's disease research and treatments #Antibody #Biology #DNA vaccination #Disease #ELISPOT #Epitope #Genetically modified mouse #Immune system #Immunization #Immunohistochemistry #Immunology #Medicinal Plants and Neuroprotection #Medicine #Neurodegeneration #Pathology #T cell #Tauopathy #Transgene #Transgenic Plants and Applications #Vaccination
4. Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies
   2015/10/03 by James P. Fuller, Jeffrey B. Stavenhagen, Søren Christensen +3 · 18 citations
   Medicine · Neuroscience · #Alzheimer's disease research and treatments #Antibody #Biology #CD68 #Genetically modified mouse #Immune system #Immunohistochemistry #Immunology #Inflammation #Integrin alpha M #Medicine #Microglia #Neuroinflammation #Neuroinflammation and Neurodegeneration Mechanisms #Pathology #Transgene #Tryptophan and brain disorders
5. Dickkopf-3 attenuates pressure overload-induced cardiac remodelling
   2014/01/09 by Yan Zhang, Yu Liu, Xue‐Hai Zhu +20 · 25 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #ASK1 #Biochemistry #Biology #Cardiac Fibrosis and Remodeling #Cardiac fibrosis #Cardiac function curve #Cardiac hypertrophy #Cell biology #Conditional gene knockout #Congenital heart defects research #Endocrinology #Fibrosis #Gene #Genetically modified mouse #Heart failure #Internal medicine #Kinase #Medicine #Mitogen-activated protein kinase kinase #Muscle hypertrophy #Phenotype #Pressure overload #Protein Kinase Regulation and GTPase Signaling #Protein kinase A #Transgene
6. Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells
   2013/08/01 by Yukiteru Ouji, Fukumi Nakamura‐Uchiyama, Fukumi Nakamura-Uchiyama +1 · 12 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cell biology #Dermal papillae #Extracellular matrix #Gene #Genetically modified mouse #Genetics #Hair Growth and Disorders #Hair follicle #In vitro #In vivo #Proteoglycan #Signal transduction #Skin and Cellular Biology Research #Transgene #Versican #Wnt signaling pathway #Wnt/β-catenin signaling in development and cancer
7. Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease
   2012/06/27 by Magdalena Kulijewicz‐Nawrot, Alexei Verkhratsky, Alexander Chvátal +3 · 28 citations
   Medicine · Neuroscience · #Alzheimer's disease research and treatments #Atrophy #Biochemistry #Biology #Cognition #Entorhinal cortex #Genetically modified mouse #Glial fibrillary acidic protein #Hippocampus #Immunohistochemistry #Medicine #Neuroinflammation and Neurodegeneration Mechanisms #Neuroscience #Neuroscience and Neuropharmacology Research #Pathology #Prefrontal cortex #Transgene
8. Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
   2011/12/05 by Andre Berner, A. K. Berner, O. Brouwers +21 · 30 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Advanced Glycation End Products research #Biochemistry #Biology #Chemistry #Chronic Kidney Disease and Diabetes #Diabetes mellitus #Diabetic retinopathy #Endocrinology #Enzyme #Genetically modified mouse #Glial fibrillary acidic protein #Glycation #Immunohistochemistry #Internal medicine #Lactoylglutathione lyase #Medicine #Methylglyoxal #Retina #Retinal #Retinal Diseases and Treatments #Transgene
9. Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease
   2011/05/31 by Charles Y. Shao, Charles Shao, Suzanne S. Mirra +5 · 28 citations
   Medicine · Neuroscience · #Alzheimer's disease #Alzheimer's disease research and treatments #Biology #Cholinesterase and Neurodegenerative Diseases #Degeneration (medical) #Disease #Gene #Genetically modified mouse #Genetics #Internal medicine #Medicine #Neurodegeneration #Neuronal degeneration #Neuropathology #Neuroscience #Neuroscience and Neuropharmacology Research #Pathology #Postsynaptic potential #Receptor #Tau pathology #Transgene
10. CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models
    2010/09/23 by Sungho Lee, Sung‐Ho Lee, Nicholas H. Varvel +5 · 36 citations
    Medicine · Neuroscience · #Alzheimer's disease #Alzheimer's disease research and treatments #Amyloid (mycology) #Amyloid beta #Biology #CX3CR1 #Chemokine #Chemokine receptor #Chemokine receptors and signaling #Disease #Genetically modified mouse #Immunology #Inflammation #Medicine #Microglia #Neurodegeneration #Neuroinflammation #Neuroinflammation and Neurodegeneration Mechanisms #Pathology #Transgene
11. Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat–Fed Mice
    2010/09/14 by Phillip J. White, Makoto Arita, Ryo Taguchi +2 · 28 citations
    Medicine · Nursing · #Adipokines, Inflammation, and Metabolic Diseases #Adipose Tissue and Metabolism #Adipose tissue #Biochemistry #Biology #Diabetes mellitus #Endocrinology #Fatty Acid Research and Health #Fatty liver #Genetically modified mouse #Inflammation #Insulin #Insulin resistance #Internal medicine #Medicine #Transgene #Type 2 diabetes #White adipose tissue
12. Smooth Muscle–Specific Deletion of Nitric Oxide–Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice
    2010/01/11 by Dieter Groneberg, Peter König, Peter König +4 · 26 citations
    Medicine · #Biochemistry #Biology #Blood Pressure and Hypertension Studies #Endocrinology #Gene #Genetically modified mouse #Guanylate cyclase #Internal medicine #Knockout mouse #Medicine #Nitric Oxide and Endothelin Effects #Nitric oxide #Receptor #Renin-Angiotensin System Studies #Smooth muscle #Soluble guanylyl cyclase #Tamoxifen #Transgene #Vascular smooth muscle
13. Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice
    2008/12/07 by Jang Hyeon Cho, Jang-Hyeon Cho, Xiuqian Mu +2 · 7 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Biology #Cell biology #Cre recombinase #Drug-Induced Ocular Toxicity #Estrogen receptor #Gene #Genetically modified mouse #Genetics #Glaucoma and retinal disorders #Neuroscience #Optic nerve #Retinal Development and Disorders #Retinal ganglion cell #Tamoxifen #Transgene
14. Myelin oligodendrocyte glycoprotein‐35–55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA‐DR2‐transgenic mice
    2004/04/05 by Cathleen Rich, Jason M. Link, Jason M. Link +12 · 18 citations
    Immunology and Microbiology · Medicine · Neuroscience · #Biology #Central nervous system #Encephalomyelitis #Experimental autoimmune encephalomyelitis #Gene #Genetically modified mouse #Genetics #Glycoprotein #Immunology #Immunotherapy and Immune Responses #Molecular biology #Monoclonal and Polyclonal Antibodies Research #Multiple sclerosis #Myelin #Myelin basic protein #Myelin oligodendrocyte glycoprotein #Neuroscience #T-cell and B-cell Immunology #Transgene
15. Electrical Coupling and Neuronal Synchronization in the Mammalian Brain
    2004/02/01 by Michael V.L Bennett, Michael V. L. Bennett, R. Suzanne Zukin +1 · 10 citations
    Biochemistry, Genetics and Molecular Biology · Neuroscience · #Biological neural network #Biology #Cell #Cell biology #Cell type #Connexin #Connexins and lens biology #Coupling (piping) #Electrical Synapses #Gap junction #Gene #Genetically modified mouse #Genetics #Ion channel regulation and function #Mammalian brain #Materials science #Neuron #Neuroscience #Neuroscience and Neuropharmacology Research #Synapse #Transgene
16. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    2003/11/25 by Alexander Egle, Alan W. Harris, Mary L. Bath +3 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Antibody #B cell #Biology #Center (category theory) #Chemistry #Chronic Lymphocytic Leukemia Research #Follicular lymphoma #Gene #Genetically modified mouse #Genetics #Germinal center #Immunology #Lymphoma #Lymphoma Diagnosis and Treatment #Medicine #PI3K/AKT/mTOR signaling in cancer #Pathology #Transgene
17. Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration
    2002/05/01 by Bernadette H LaMonte, Bernadette H. LaMonte, Karen E. Wallace +12 · 2 citations
    Medicine · Neuroscience · #Amyotrophic Lateral Sclerosis Research #Amyotrophic lateral sclerosis #Axoplasmic transport #Biology #Cell biology #Disease #Dynactin #Dynein #Genetically modified mouse #Genetics #Medicine #Microtubule #Motor neuron #Neurogenetic and Muscular Disorders Research #Neurological diseases and metabolism #Neuron #Neuroscience #Pathology #Spinal cord #Transgene
18. Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein
    2001/07/06 by Dawinder S. Sohal, Mai Nghiem, Mai P. Nghiem +8 · 30 citations
    Biochemistry, Genetics and Molecular Biology · #Biology #CRISPR and Genetic Engineering #Cell biology #Cre recombinase #Cre-Lox recombination #Fusion protein #Gene #Gene expression #Gene targeting #Genetically modified mouse #Genetics #Molecular biology #Mutant #RNA and protein synthesis mechanisms #Recombinant DNA #Recombinase #Recombination #Tamoxifen #Transgene #Viral Infectious Diseases and Gene Expression in Insects
19. Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein
    1998/09/01 by Douglas H. Smith, Michio Nakamura, Tracy K. McIntosh +14 · 26 citations
    Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Aluminum toxicity and tolerance in plants and animals #Alzheimer's disease #Alzheimer's disease research and treatments #Amyloid (mycology) #Amyloid precursor protein #Biochemistry #Biology #Disease #Endocrinology #Gene #Genetically modified mouse #Hippocampal formation #Hippocampus #Histopathology #Internal medicine #Medicine #Neuroscience #Pathology #Psychiatry #S100 Proteins and Annexins #Transgene #Traumatic brain injury
20. Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains
    1997/08/01 by Robert Feil, Jürgen Wagner, J D Wagner +3 · 39 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Biology #Cell biology #Chemical Synthesis and Analysis #Chemistry #Chimera (genetics) #Cre recombinase #DNA #DNA and Nucleic Acid Chemistry #Estrogen and related hormone effects #Estrogen receptor #Fusion protein #Gene #Genetically modified mouse #Genetics #Ligand (biochemistry) #Molecular biology #Mutagenesis #Mutation #Receptor #Recombinant DNA #Recombinase #Recombination #Transgene