CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

2010/09/23 by Sungho Lee, Sung‐Ho Lee, Nicholas H. Varvel +5 · 34 citations
Neuroscience · Medicine · #Neuroinflammation and Neurodegeneration Mechanisms #Alzheimer's disease research and treatments #Chemokine receptors and signaling

paper · pdf · doi:10.2353/ajpath.2010.100265

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• Microglia in Alzheimer’s disease
• Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone
• Role of Chemokines in the Development and Progression of Alzheimer’s Disease
• ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
• How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease
• Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
• Microglial interferon signaling and Aβ plaque pathology are enhanced in female 5xFAD Alzheimer’s disease mice, independent of estrous cycle stage
• Microglia Development and Function
• Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week
• Regulation of tau pathology by the microglial fractalkine receptor. [europepmc]
• CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. [europepmc]
• The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. [europepmc]
• Innate immunity in the central nervous system. [europepmc]
• Review: microglia of the aged brain: primed to be activated and resistant to regulation. [europepmc]
• Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. [europepmc]
• Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. [europepmc]
• Microglia, seen from the CX3CR1 angle. [europepmc]
• Microglia during development and aging. [europepmc]
• Microglia development and function. [europepmc]
• Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. [europepmc]
• IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. [europepmc]
• Inefficient clearance of myelin debris by microglia impairs remyelinating processes. [europepmc]
• Neuroinflammation in Alzheimer's disease. [europepmc]
• Microglia in Alzheimer's disease. [europepmc]
• Microglia in Alzheimer's disease. [europepmc]
• The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade. [europepmc]
• Chemokine-Induced Macrophage Polarization in Inflammatory Conditions. [europepmc]
• Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. [europepmc]
• Bidirectional Microglia-Neuron Communication in Health and Disease. [europepmc]
• Inflammation as a central mechanism in Alzheimer's disease. [europepmc]
• Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. [europepmc]
• Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy. [europepmc]
• ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. [europepmc]
• Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. [europepmc]