1. Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice
   2025/08/26 by Hayley E. McMorrow, Andrew Cohen, Carolyn M. Lorch +6 · 1 voice · 8 citations
   Medicine · Neuroscience · #Agonist #Anorectic #Appetite #Biology #Diabetes Treatment and Management #Diabetes mellitus #Endocrinology #Food intake #Glucagon-like peptide-1 #Incretin #Internal medicine #Liraglutide #Medicine #Neuropeptide #Neuropeptide Y receptor #Neuropeptides and Animal Physiology #Peptide YY #Receptor #Regulation of Appetite and Obesity #Semaglutide #Type 2 diabetes
2. Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation
   2025/01/30 by Areesha Moiz, Kristian B. Filion, Michael A. Tsoukas +4 · 1 voice · 29 citations
   Medicine · Neuroscience · #Agonist #Appetite #Diet and metabolism studies #Endocrinology #Energy metabolism #Internal medicine #Medicine #Neuroscience #Obesity #Peripheral #Pharmacology and Obesity Treatment #Receptor #Regulation of Appetite and Obesity #Weight loss
3. Cardiovascular and diabetes outcomes among patients with obesity and type 2 diabetes after metabolic bariatric surgery or glucagon-like peptide 1 receptor agonist treatment
   2024/08/30 by Erik Stenberg, Johan Ottosson, Yang Cao +2 · 1 voice · 7 citations
   Medicine · #Agonist #Bariatric Surgery and Outcomes #Cardiovascular Disease and Adiposity #Diabetes Treatment and Management #Diabetes mellitus #Endocrinology #Gastric bypass #Gastric bypass surgery #Gastroenterology #Glucagon-like peptide 1 receptor #Internal medicine #Medicine #Obesity #Receptor #Surgery #Type 2 diabetes #Weight loss
4. Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes
   2024/02/22 by Pedro Cardoso, Katherine Young, Katie G. Young +20 · 19 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Agonist #Biology #Diabetes Management and Research #Diabetes Treatment and Management #Diabetes mellitus #Endocrinology #Gene #Genetic Associations and Epidemiology #Genetics #Glucagon-like peptide 1 receptor #Human physiology #Internal medicine #Medicine #Pharmacology #Phenotype #Receptor #Type 2 diabetes
5. Duration of ergovaline exposure influences serotonin-mediated vasoactivity of bovine mesenteric vasculature
   2023/01/01 by Ronald J Trotta, D. L. Harmon, David L Harmon +3 · 5 citations
   Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #5-HT receptor #Agonist #Anatomy #Artery #Biology #Blood vessel #Chemical synthesis and alkaloids #Chemistry #Endocrinology #Internal medicine #Medicine #Mesenteric arteries #Plant Toxicity and Pharmacological Properties #Plant and fungal interactions #Receptor #Serotonin #Vasoconstriction
6. Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice
   2022/11/09 by Junyan Lv, Yanhong Duan, Xinhe Wang +7 · 4 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Acetylcholine #Agonist #Alzheimer's disease #Biology #Cholinergic #Cholinesterase and Neurodegenerative Diseases #Disease #Hippocampal formation #Hippocampus #Internal medicine #Knockout mouse #Long-term potentiation #Medicine #Morris water navigation task #Neuroscience #Nicotinic Acetylcholine Receptors Study #Nicotinic agonist #Pharmacology #Presenilin #Psychology #Receptor #Receptor Mechanisms and Signaling #Synaptic plasticity
7. Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats
   2022/08/12 by Mozhdeh Radpour, Samira Choopani, Hamid Gholami Pourbadie +1 · 7 citations
   Immunology and Microbiology · Medicine · #Agonist #Anesthesia #Endocrinology #Epileptogenesis #Hippocampus #Immune Response and Inflammation #Inflammation #Internal medicine #Medicine #Microglia #Neonatal and fetal brain pathology #Neuroinflammation #Neuroprotection #Pharmacology #Receptor #TLR4 #Traumatic Brain Injury and Neurovascular Disturbances #Traumatic brain injury
8. Physiopathological Relevance of D-Serine in the Mammalian Cochlea
   2021/12/17 by Jing Wang, Nicolas Serratrice, Cindy J. Lee +5 · 1 citation
   Biochemistry, Genetics and Molecular Biology · Neuroscience · Chemistry · #Amino Acid Enzymes and Metabolism #Neuroscience and Neuropharmacology Research #Epigenetics and DNA Methylation #Spiral ganglion #Cochlea #NMDA receptor #Neuroscience #Agonist #Excitotoxicity #Chemistry #Receptor #Biology #Biochemistry
9. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes
   2021/06/25 by Juan P. Frías, Melanie J. Davies, Julio Rosenstock +6 · 1 citation
   Medicine · #Agonist #Diabetes Treatment and Management #Diabetes mellitus #Diabetes, Cardiovascular Risks, and Lipoproteins #Endocrinology #Glucagon-like peptide 1 receptor #Glucagon-like peptide-1 #Hyperglycemia and glycemic control in critically ill and hospitalized patients #Internal medicine #Liraglutide #Medicine #Receptor #Semaglutide #Type 2 diabetes
10. Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity
    2021/01/01 by Kathleen M. McAndrews, Sara P.Y. Che, Sara P.Y. +2 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Agonist #Biochemistry #Biology #Cancer research #Cell biology #Chemistry #Extracellular vesicles in disease #Immune system #Immunity #Immunology #Medicine #Microvesicles #Pharmacology #Physics #Receptor #Sting #Viral Infections and Vectors #interferon and immune responses
11. Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication
    2020/12/24 by Andrea Marcellini, Dawid Swieboda, Anabel Guedán +7 · 12 citations
    Immunology and Microbiology · Medicine · #Agonist #Asthma #Asthma and respiratory diseases #Budesonide #Fluticasone #Fluticasone propionate #Formoterol #Formoterol Fumarate #Glucocorticoid #Glucocorticoid receptor #IL-33, ST2, and ILC Pathways #Immune Cell Function and Interaction #Immunology #Interferon #Internal medicine #Medicine #Pharmacology #Receptor #Rhinovirus #Viral replication #Virus
12. d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders
    2020/06/09 by Herman Wolosker, Darrick T. Balu · 1 citation
    Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · Medicine · Chemistry · #Amino Acid Enzymes and Metabolism #Neuroscience and Neuropharmacology Research #Tryptophan and brain disorders #NMDA receptor #Anxiety #Serine #Neuroscience #Psychology #Agonist #Glutamate receptor #Mood disorders #Glycine #Extinction (optical mineralogy) #Mood #Psychiatry #Medicine #Receptor #Internal medicine #Chemistry #Biochemistry #Amino acid
13. Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression
    2019/11/01 by Shelly R Nason, Shelly Nason, Teayoun Kim +9 · 10 citations
    Medicine · Neuroscience · Nursing · #Agonist #Biochemical Analysis and Sensing Techniques #Biology #Endocrinology #Fatty liver #Glucagon #Glucagon receptor #Glucagon-like peptide 1 receptor #Insulin #Internal medicine #Leptin #Leptin receptor #Medicine #Obesity #Pancreatic function and diabetes #Receptor #Regulation of Appetite and Obesity #Steatosis
14. Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia
    2018/09/07 by Wojciech Jurczak, Krzysztof Chojnowski, Jiřı́ Mayer +6 · 30 citations
    Medicine · #Agonist #Biology #Blood groups and transfusion #Blood properties and coagulation #Eltrombopag #Genetics #Haematopoiesis #Immune system #Immune thrombocytopenia #Immunology #Internal medicine #Medicine #Platelet #Platelet Disorders and Treatments #Receptor #Romiplostim #Thrombopoietin #Thrombopoietin receptor
15. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations
    2018/02/17 by Miriam A Snider, David L Harmon, D. L. Harmon +2 · 7 citations
    Agricultural and Biological Sciences · Chemistry · Medicine · #5-HT receptor #Abomasum #Agonist #Artery #Biochemistry #Biology #Blood vessel #Chemistry #Contractility #Endocrinology #Internal medicine #Medicine #Mesenteric arteries #Plant and fungal interactions #Receptor #Rumen #Serotonin #Vasoconstriction
16. A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration
    2017/04/13 by Rie Yamamoto, Tomohiro Aoki, Hirokazu Koseki +12 · 18 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Agonist #Biochemistry #Biology #Cell biology #Endocrinology #Endothelial stem cell #Endothelium #In vitro #Internal medicine #Intracerebral and Subarachnoid Hemorrhage Research #Intracranial Aneurysms: Treatment and Complications #Medicine #Pharmacology #Receptor #S1PR1 #Sphingolipid Metabolism and Signaling #Sphingosine #Sphingosine-1-phosphate #Sphingosine-1-phosphate receptor #Vascular endothelial growth factor #Vascular endothelial growth factor A #Vascular permeability
17. Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes
    2015/09/17 by Cristina Hernández, Patricia Bogdanov, Lídia Corraliza +10 · 32 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Adenosine and Purinergic Signaling #Agonist #Biology #Diabetes Treatment and Management #Diabetes mellitus #Diabetic retinopathy #Endocrinology #Exenatide #Internal medicine #Liraglutide #Medicine #Neurodegeneration #Neuroprotection #Neuroscience #Ophthalmology #Pharmacology #Receptor #Retina #Retinal #Retinal Diseases and Treatments #Systemic administration #Type 2 diabetes
18. Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
    2015/09/08 by Todd Bartkowiak, Shailbala Singh, Guojun Yang +6 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Agonist #Antibody #Cancer #Cancer Immunotherapy and Biomarkers #Cancer research #Cervical cancer #Epitope #HPV infection #HPV vaccines #Immune system #Immunology #Immunotherapy #Immunotherapy and Immune Responses #Internal medicine #Medicine #Oncology #Peptide vaccine #Receptor #Vaccination #vaccines and immunoinformatics approaches
19. Cannabidiol is a negative allosteric modulator of the cannabinoid CB 1 receptor
    2015/07/27 by R B Laprairie, Robert B. Laprairie, Amina M. Bagher +5 · 35 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Agonist #Allosteric modulator #Allosteric regulation #Biochemistry #Biology #Cannabidiol #Cannabinoid #Cannabinoid receptor #Cannabinoid receptor type 2 #Cannabis #Cannabis and Cannabinoid Research #Chemistry #Functional selectivity #Medicine #Neuroscience of respiration and sleep #Pharmacological Receptor Mechanisms and Effects #Pharmacology #Receptor
20. Antidepressant-like effect of atorvastatin in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway
    2014/10/14 by Arash Shahsavarian, Shiva Javadi, Samane Jahanabadi +6 · 10 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Adipose Tissue and Metabolism #Agonist #Antagonist #Antidepressant #Atorvastatin #Behavioural despair test #Chemistry #Diabetes mellitus #Endocrinology #Hippocampus #Internal medicine #Medicine #Nitric oxide #Nitric oxide synthase #Peroxisome Proliferator-Activated Receptors #Peroxisome proliferator-activated receptor #Pharmacology #Pioglitazone #Receptor #Receptor Mechanisms and Signaling #Type 2 diabetes
21. GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans
    2014/07/29 by Liselotte van Bloemendaal, Richard G. IJzerman, Jennifer S. ten Kulve +6 · 35 citations
    Medicine · Neuroscience · #Agonist #Amygdala #Appetite #Brain stimulation reward #Diabetes Treatment and Management #Diabetes mellitus #Diet and metabolism studies #Endocrinology #Exenatide #Glucagon-like peptide 1 receptor #Internal medicine #Medicine #Nucleus accumbens #Orbitofrontal cortex #Prefrontal cortex #Receptor #Regulation of Appetite and Obesity #Type 2 diabetes
22. Agomelatine but not melatonin improves fatigue perception: A longitudinal proof-of-concept study
    2014/02/24 by M. Pardini, Matteo Pardini, Christian Cordano +17 · 1 voice · 2 citations
    Medicine · Neuroscience · Psychology · #Agomelatine #Agonist #Antidepressant #Circadian rhythm and melatonin #Endocrinology #Fibromyalgia and Chronic Fatigue Syndrome Research #Internal medicine #Medicine #Melatonin #Melatonin receptor #Olfactory and Sensory Function Studies #Psychology #Receptor #Serotonin
23. Functional remodelling of arterial endothelium during early postnatal development in rats
    2013/05/31 by Dina Gaynullina, Dina K. Gaynullina, Lubomir T. Lubomirov +7 · 13 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Agonist #Angiogenesis and VEGF in Cancer #Cardiovascular Health and Disease Prevention #Circulatory system #Endocrinology #Endothelium #Internal medicine #Medicine #Nitric Oxide and Endothelin Effects #Receptor
24. Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
    2013/01/01 by África Flores, Rafaël Maldonado, Fernando Berrendero · 1 citation
    Medicine · Neuroscience · #2-Arachidonoylglycerol #Agonist #Biochemistry #Biology #Cannabinoid #Cannabinoid receptor #Cannabinoid receptor type 2 #Cannabis and Cannabinoid Research #Depolarization-induced suppression of inhibition #Endocannabinoid system #G protein-coupled receptor #Neuropeptide #Neuroscience #Neuroscience of respiration and sleep #Orexin #Receptor #Sleep and Wakefulness Research
25. The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice
    2012/10/03 by Farzad Alemi, Daniel P. Poole, Jonathan Chiu +5 · 33 citations
    Chemistry · Medicine · #5-HT4 receptor #Agonist #Bile acid #Biology #Chemistry #Congenital gastrointestinal and neural anomalies #Deoxycholic acid #Drug Transport and Resistance Mechanisms #Endocrinology #G protein-coupled bile acid receptor #Gastrointestinal motility and disorders #Internal medicine #Lithocholic acid #Medicine #Peristalsis #Receptor
26. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons
    2011/09/10 by Yingying Wang, Ying-Ying Wang, Jiong Qin +4 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Afterhyperpolarization #Agonist #Anesthesia #Biology #Chemistry #Depolarization #Electrophysiology #Endocrinology #Epilepsy #Epilepsy research and treatment #Febrile seizure #Hyperthermia #Internal medicine #Ion channel regulation and function #Medicine #Membrane potential #Neuroscience #Neuroscience and Neuropharmacology Research #Patch clamp #Receptor #Status epilepticus
27. Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease
    2011/07/26 by Marie‐Thérèse Armentero, Marie Therese Armentero, Annalisa Pinna +5 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Adenosine #Adenosine A2A receptor #Adenosine and Purinergic Signaling #Adenosine receptor #Agonist #Basal ganglia #Biology #Central nervous system #Disease #Dopamine #Dopamine receptor D2 #Internal medicine #Medicine #Neurodegeneration #Neuroscience #Parkinson's disease #Pharmacological Receptor Mechanisms and Effects #Pharmacology #Receptor #Receptor Mechanisms and Signaling
28. Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    2010/12/22 by Luciano De Petrocellis, Alessia Ligresti, Aniello Schiano Moriello +6 · 32 citations
    Chemistry · Medicine · Neuroscience · #Agonist #Anandamide #Biochemistry #Biology #Cannabidiol #Cannabinoid #Cannabinoid receptor #Cannabis and Cannabinoid Research #Chemistry #Diacylglycerol lipase #Endocannabinoid system #Fatty acid amide hydrolase #Ion Channels and Receptors #Medicine #Monoacylglycerol lipase #Neuroscience of respiration and sleep #Pharmacology #Receptor #TRPV1 #Transient receptor potential channel
29. Thermosensitive transient receptor potential channels in human corneal epithelial cells
    2010/11/10 by Stefan Mergler, Fabian Garreis, Monika Sahlmüller +3 · 25 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Agonist #Biochemistry #Biology #Biophysics #Calcium #Capsazepine #Cell biology #Channel blocker #Chemistry #Connexins and lens biology #Intracellular #Ion Channels and Receptors #Ionomycin #Membrane potential #Neurobiology and Insect Physiology Research #Patch clamp #Receptor #Ruthenium red #TRPC #TRPC6 #TRPM8 #TRPV #TRPV1 #TRPV4 #Transient receptor potential channel
30. ApoE Promotes the Proteolytic Degradation of Aβ
    2008/06/01 by Qingguang Jiang, C.Y. Daniel Lee, Shweta Mandrekar +18 · 2 citations
    Chemistry · Medicine · Neuroscience · #Agonist #Alzheimer's disease research and treatments #Apolipoprotein E #Autophagy #Biochemistry #Biology #Cell biology #Chemistry #Cholesterol and Lipid Metabolism #Disease #Drug Transport and Resistance Mechanisms #Endocrinology #Enzyme #Inflammation #Insulin-degrading enzyme #Internal medicine #Lipid-anchored protein #Medicine #Microglia #Neprilysin #Neuroinflammation #Neuroscience #Receptor

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