- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells
2025/08/25 by Katie Greenin‐Whitehead, Eyal Rozenfeld, Anthony Moreno‐Sanchez +5 · 2 voices · 2 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Animal Behavior and Reproduction #Biochemistry #Biology #Cell biology #Cell culture #Chemistry #Drosophila melanogaster #Ectopic expression #Electrophysiology #Endocrinology #Endogeny #Genetics #Homeostasis #Insect and Arachnid Ecology and Behavior #Ion channel #Mushroom bodies #Neurobiology and Insect Physiology Research #Neuroscience #Patch clamp #Receptor #Sodium #Sodium channel
- Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials
2024/12/19 by Phil Alexander Köster, Enrico Leipold, Jenny Tigerholm +4 · 8 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biochemistry #Biology #Biophysics #Chemistry #Current clamp #Depolarization #Electrophysiology #Gating #Ion channel regulation and function #Membrane potential #Neuroscience #Neuroscience and Neuropharmacology Research #Nociception #Nociceptor #Pain Mechanisms and Treatments #Patch clamp #Physics #Receptor #Sodium #Sodium channel #Subthreshold conduction
- Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons
2023/04/26 by Swetha E. Murthy · 14 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biochemistry #Biology #Biophysics #Channel (broadcasting) #Chemical and Physical Studies #Chemistry #Computer science #Conductance #Dorsal root ganglion #Electrophysiology #Erythrocyte Function and Pathophysiology #Ion channel #Ion channel regulation and function #Membrane potential #Neuroscience #Patch clamp #Physics #Receptor #Sensory system #Somatosensory system #Telecommunications
- The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
2022/01/17 by Kristopher M. Kahlig, Liam Scott, Robert J. Hatch +5 · 17 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · Psychology · #Anesthesia #Anticonvulsant #Biochemistry #Carbamazepine #Chemistry #Epilepsy #Inhibitory postsynaptic potential #Internal medicine #Ion channel regulation and function #Lamotrigine #Medicine #Neuroscience #Neuroscience and Neural Engineering #Neuroscience and Neuropharmacology Research #Patch clamp #Pharmacology #Psychology #Receptor #Sodium #Sodium channel #Sodium channel blocker #Tolerability
- Regulation of voltage-gated potassium channels by PI(4,5)P2
2012/07/30 by Martin Kruse, Gerald R.V. Hammond, Gerald Hammond +1 · 28 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biochemistry #Biology #Biophysics #Cardiac electrophysiology and arrhythmias #Cell biology #Chemistry #Depolarization #G protein #G protein-coupled inwardly-rectifying potassium channel #Inward-rectifier potassium ion channel #Ion channel #Ion channel regulation and function #Membrane potential #Neuroscience and Neuropharmacology Research #Patch clamp #Phosphatase #Phosphorylation #Pi #Potassium channel #Receptor #Signal transduction #Voltage-gated potassium channel
- Hyperthermia induces epileptiform discharges in cultured rat cortical neurons
2011/09/10 by Ying-Ying Wang, Yingying Wang, Jiong Qin +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Afterhyperpolarization #Agonist #Anesthesia #Biology #Chemistry #Depolarization #Electrophysiology #Endocrinology #Epilepsy #Epilepsy research and treatment #Febrile seizure #Hyperthermia #Internal medicine #Ion channel regulation and function #Medicine #Membrane potential #Neuroscience #Neuroscience and Neuropharmacology Research #Patch clamp #Receptor #Status epilepticus
- Thermosensitive transient receptor potential channels in human corneal epithelial cells
2010/11/10 by Stefan Mergler, Fabian Garreis, Monika Sahlmüller +3 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Agonist #Biochemistry #Biology #Biophysics #Calcium #Capsazepine #Cell biology #Channel blocker #Chemistry #Connexins and lens biology #Intracellular #Ion Channels and Receptors #Ionomycin #Membrane potential #Neurobiology and Insect Physiology Research #Patch clamp #Receptor #Ruthenium red #TRPC #TRPC6 #TRPM8 #TRPV #TRPV1 #TRPV4 #Transient receptor potential channel
- Arachidonic acid inhibition of L-type calcium (CaV1.3b) channels varies with accessory CaVβ subunits
2009/03/30 by Mandy L. Roberts-Crowley, Ann R. Rittenhouse · 19 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Arachidonic acid #Biochemistry #Biology #Biophysics #Calcium #Cardiac electrophysiology and arrhythmias #Cav1.2 #Chemistry #Electrophysiology #Enzyme #Gating #Ion channel regulation and function #L-type calcium channel #Neuroscience #Neuroscience and Neuropharmacology Research #Patch clamp #Protein subunit #Receptor #Voltage-dependent calcium channel
- Ca2+-activated K+ Channels in Murine Endothelial Cells: Block by Intracellular Calcium and Magnesium
2008/01/14 by Jonathan Ledoux, Adrian D. Bonev, Mark T. Nelson · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Apamin #BK channel #Biochemistry #Biology #Biophysics #Calcium #Calcium-activated potassium channel #Cardiac action potential #Cardiac electrophysiology and arrhythmias #Charybdotoxin #Chemistry #Depolarization #Electrophysiology #Internal medicine #Inward-rectifier potassium ion channel #Ion channel #Ion channel regulation and function #Medicine #Membrane potential #Neuroscience and Neuropharmacology Research #Patch clamp #Potassium channel #Receptor #Repolarization #Reversal potential #SK channel #T-type calcium channel #Voltage-dependent calcium channel
- STIM1, an essential and conserved component of store-operated Ca2 + channel function
2005/05/02 by Jack Roos, Paul J. DiGregorio, Andriy V. Yeromin +11 · 35 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biochemistry #Biology #Cell biology #Chemistry #Endoplasmic reticulum #Extracellular #Gene #Gene knockdown #Genetics #HEK 293 cells #Ion Channels and Receptors #Ion channel regulation and function #Jurkat cells #ORAI1 #Patch clamp #RNA #RNA interference #Receptor #Respiratory and Cough-Related Research #STIM1 #T cell #Thapsigargin
- Mechanisms of postinhibitory rebound and its modulation by serotonin in excitatory swim motor neurons of the medicinal leech
2005/04/18 by James D. Angstadt, Jeffrey L. Grassmann, Kraig M. Theriault +1 · 1 citation
Agricultural and Biological Sciences · Chemistry · Environmental Science · Neuroscience · Psychology · #5-HT receptor #Animal Behavior and Reproduction #Biochemistry #Biology #Biophysics #Chemistry #Depolarization #Electrophysiology #Excitatory postsynaptic potential #Hirudo medicinalis #Hyperpolarization (physics) #Inhibitory postsynaptic potential #Leech #Membrane potential #Neurobiology and Insect Physiology Research #Neuroscience #Patch clamp #Physiological and biochemical adaptations #Psychology #Receptor #Serotonin #Stereochemistry #Stimulus (psychology)
- A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells
2004/04/08 by Robert B. Clark, Matteo E. Mangoni, Andreas Lueger +3 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · Neuroscience · Chemistry · #Cardiac electrophysiology and arrhythmias #Ion channel regulation and function #Neuroscience and Neural Engineering #Repolarization #Depolarization #Diastolic depolarization #Chemistry #Pacemaker potential #Membrane potential #Sinoatrial node #Biophysics #Internal medicine #Myocyte #Patch clamp #Electrophysiology #Endocrinology #Biochemistry #Biology #Medicine #Heart rate
- Overexpressed Cavβ3 Inhibits N-type (Cav2.2) Calcium Channel Currents through a Hyperpolarizing Shift of “Ultra-slow” and “Closed-state” Inactivation
2004/03/15 by Takahiro Yasuda, Richard J. Lewis, David J. Adams · 11 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Biochemistry #Biology #Biophysics #Calcium #Chemistry #Conductance #Divalent #Ion channel regulation and function #L-type calcium channel #Membrane potential #Neuroscience and Neural Engineering #Neuroscience and Neuropharmacology Research #Patch clamp #Protein subunit #Receptor #Reversal potential #Voltage-dependent calcium channel #Xenopus
- A Chloride Channel at the Basolateral Membrane of the Distal-convoluted Tubule
2003/03/31 by Stéphane Lourdel, Stéphane Lourdel, Marc Paulais +4 · 22 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Biochemistry #Biology #Biophysics #Calcium #Chemistry #Chloride channel #Cotransporter #Distal convoluted tubule #Epithelial polarity #Forskolin #Intracellular #Ion Channels and Receptors #Ion Transport and Channel Regulation #Ion channel regulation and function #Ion transporter #Membrane #Membrane potential #Patch clamp #Pipette #Reabsorption #Reversal potential #Selectivity #Sodium
- Gating Kinetics of the α1i T-Type Calcium Channel
2001/10/15 by Charles J. Frazier, Jose R. Serrano, José Ramón Serrano +6 · 9 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biochemistry #Biology #Biophysics #Calcium #Cardiac electrophysiology and arrhythmias #Chemistry #Electrophysiology #Gating #HEK 293 cells #Ion channel regulation and function #Kinetics #Neuroscience #Neuroscience and Neural Engineering #Patch clamp #Physics #Potassium channel #Time constant #Voltage-dependent calcium channel
- Biophysical Characterization of Rat Caudal Hypothalamic Neurons: Calcium Channel Contribution to Excitability
2000/12/01 by Yi-Ping Fan, Eric M. Horn, Tony G. Waldrop · 1 citation
Neuroscience · Psychology · Chemistry · #Neuroscience of respiration and sleep #Neuroendocrine regulation and behavior #Sleep and Wakefulness Research #Bursting #Depolarization #Membrane potential #Neuroscience #Chemistry #Patch clamp #Biophysics #Neuron #Nifedipine #Electrophysiology #Current clamp #Voltage clamp #Calcium #Slice preparation #Resting potential #Biology
- Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila melanogaster GABA receptor (RDL) stably expressed in a Drosophila cell line
2000/08/01 by Françoise Grolleau, David B. Sattelle, David B Sattelle · 5 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Biochemistry #Biology #Biophysics #Chemistry #Chloride channel #Drosophila melanogaster #Electrophysiology #Fipronil #GABA receptor #GABAA receptor #Insect and Pesticide Research #Ion channel regulation and function #Neuroscience #Nicotinic Acetylcholine Receptors Study #Patch clamp #Picrotoxin #Receptor #Reversal potential
- Electrophysiology of Myocardial Cells in the Epicardial, Midmyocardial, and Endocardial Layers of the Ventricle
1997/03/01 by Anton Lukas · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Cardiac electrophysiology and arrhythmias #Ion channel regulation and function #Cardiac Arrhythmias and Treatments #Endocardium #Repolarization #Medicine #Ventricle #Internal medicine #Cardiology #Electrophysiology #Stimulation #Cardiac transient outward potassium current #Patch clamp
- Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K.
1994/10/01 by Lawrence G. Palmer, L G Palmer, Lida Antonian +3 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Amiloride #Apical membrane #Biochemistry #Biology #Biophysics #Chemistry #Conductance #Depolarization #Endocrinology #Internal medicine #Ion Transport and Channel Regulation #Ion channel #Ion channel regulation and function #Medicine #Membrane #Membrane potential #Neuroscience and Neuropharmacology Research #Ouabain #Patch clamp #Physics #Pipette #Receptor #Sodium
- The use of the patch clamp technique to study second messenger-mediated cellular events
1988/09/01 by E. Neher, Erwin Neher · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Biology #Biophysics #Cell biology #Chemistry #Electrophysiology #Ion channel regulation and function #Molecular biology #Neuroscience #Neuroscience and Neuropharmacology Research #Nicotinic Acetylcholine Receptors Study #Patch clamp #Physics
- Veratridine modifies open sodium channels.
1988/03/01 by Steven Barnes, S Barnes, B Hille +1 · 11 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Analytical Chemistry (journal) #Biochemistry #Biology #Biophysics #Chemistry #Chromatography #Conductance #Depolarization #Electrophysiology #Ion channel regulation and function #Membrane potential #Neuroscience #Neuroscience and Neural Engineering #Neuroscience and Neuropharmacology Research #Neurotoxin #Patch clamp #Physics #Reversal potential #Sodium #Sodium channel #Veratridine
- Ionic events responsible for the cardiac resting and action potential
1982/01/01 by Martin Morad, Leslie Tung · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Biology #Biophysics #Cardiac action potential #Cardiac electrophysiology and arrhythmias #Cardiac transient outward potassium current #Chemistry #Depolarization #Electrophysiology #Internal medicine #Ion #Ion channel #Ion channel regulation and function #Ion transporter #Medicine #Membrane potential #Neuroscience and Neural Engineering #Patch clamp #Plateau (mathematics) #Repolarization #Resting potential #Sodium #Sodium channel #Ventricular action potential
- Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
1981/08/01 by Owen P. Hamill, O. P. Hamill, Alain Marty +6 · 7 citations
Chemistry · Engineering · Neuroscience · #Artificial intelligence #Biology #Biophysics #Chemistry #Computer science #Current (fluid) #Current clamp #Electrical engineering #Electrophysiology #Engineering #Materials science #Membrane #Microfluidic and Bio-sensing Technologies #Neural dynamics and brain function #Neuroscience #Neuroscience and Neural Engineering #Patch clamp #Resolution (logic)
- The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes
1978/07/01 by Erwin Neher, Bert Sakmann, Joe Henry Steinbach · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Neuroscience · #Advanced Sensor and Energy Harvesting Materials #Biochemistry #Biology #Biophysics #Chemistry #Current (fluid) #Ion channel regulation and function #Membrane #Neuroscience and Neural Engineering #Patch clamp #Physics #Pipette #Receptor