Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity

2021/01/01 by Kathleen M. McAndrews, Sara P.Y. Che, Sara P.Y. +2 · 25 citations
Immunology and Microbiology · Medicine · Biochemistry, Genetics and Molecular Biology · #interferon and immune responses #Viral Infections and Vectors #Extracellular vesicles in disease

paper · doi:10.1016/j.jbc.2021.100523

Abstract

specifically, in enhancing cancer therapy outcomes.

Cited by

• Polyvalent design in the cGAS-STING pathway. [europepmc]
• Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics. [europepmc]
• Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. [europepmc]
• Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy. [europepmc]
• Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy. [europepmc]
• Exosome-Mediated Therapeutic Strategies for Management of Solid and Hematological Malignancies. [europepmc]
• Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy. [europepmc]
• The roles of extracellular vesicles in the immune system. [europepmc]
• Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling. [europepmc]
• Extracellular Vesicles and Their Roles in the Tumor Immune Microenvironment. [europepmc]
• cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus. [europepmc]
• Endogenous Lipid Carriers-Bench-to-Bedside Roadblocks in Production and Drug Loading of Exosomes. [europepmc]
• The role of extracellular vesicles in cancer. [europepmc]
• cGAMP the travelling messenger. [europepmc]
• Exosomes: potential diagnostic markers and drug carriers for adenomyosis. [europepmc]
• Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment. [europepmc]
• Extracellular vesicles as tools and targets in therapy for diseases. [europepmc]
• Application of exosomes in tumor immunity: recent progresses. [europepmc]
• The biology and function of extracellular vesicles in immune response and immunity. [europepmc]
• cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics. [europepmc]
• Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung. [europepmc]
• Engineered Immunomodulatory Extracellular Vesicles from Epithelial Cells with the Capacity for Stimulation of Innate and Adaptive Immunity in Cancer and Autoimmunity. [europepmc]
• Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer. [europepmc]
• Engineered exosomes: a promising drug delivery platform with therapeutic potential. [europepmc]
• Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy. [europepmc]

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