- Cannabidiol is a negative allosteric modulator of the cannabinoid CB 1 receptor
2015/07/27 by R B Laprairie, Robert B. Laprairie, A M Bagher +5 · 36 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Agonist #Allosteric modulator #Allosteric regulation #Biochemistry #Biology #Cannabidiol #Cannabinoid #Cannabinoid receptor #Cannabinoid receptor type 2 #Cannabis #Cannabis and Cannabinoid Research #Chemistry #Functional selectivity #Medicine #Neuroscience of respiration and sleep #Pharmacological Receptor Mechanisms and Effects #Pharmacology #Receptor
- Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
2011/07/12 by Ethan B Russo, Ethan B. Russo · 38 citations
Agricultural and Biological Sciences · Chemistry · Medicine · Nursing · #Biochemical Analysis and Sensing Techniques #Biochemistry #Cannabidiol #Cannabinoid #Cannabis #Cannabis and Cannabinoid Research #Chemistry #Dronabinol #Effects of cannabis #GABA and Rice Research #Hallucinogen #Medicine #Pharmacology #Psychiatry #Terpenoid
- Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses
1999/03/01 by Justin P. Meschler, J Meschler · 4 citations
Chemistry · Medicine · Neuroscience · Pharmacology, Toxicology and Pharmaceutics · #Agonist #Biochemistry #Biology #Cannabinoid #Cannabinoid Receptor Agonists #Cannabinoid receptor #Cannabinoid receptor type 2 #Cannabis and Cannabinoid Research #Chemistry #Forensic Toxicology and Drug Analysis #Neurotransmitter Receptor Influence on Behavior #Pharmacology #Receptor
- A novel probe for the cannabinoid receptor
1992/05/01 by William A. Devane, Aviva Breuer, Tzviel Sheskin +3 · 1 citation
Chemistry · Medicine · #Agonist #Analytical Methods in Pharmaceuticals #Biochemistry #Biological activity #Cannabinoid #Cannabinoid Receptor Agonists #Cannabinoid receptor #Cannabis and Cannabinoid Research #Chemical synthesis #Chemistry #Dronabinol #Drug Transport and Resistance Mechanisms #ED50 #Epimer #In vitro #Intrinsic activity #Ligand (biochemistry) #Potency #Receptor #Stereochemistry #Tetrahydrocannabinol
- Cannabimimetic activity (Δ1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons
1986/08/01 by Torbjörn U.C. Järbe, T.U.C. Järbe, Arto J. Hiltunen +4 · 1 citation
Chemistry · Medicine · Neuroscience · Nursing · Psychology · #Biochemical Analysis and Sensing Techniques #Biochemistry #Biology #Cannabidiol #Cannabinoid #Cannabis #Cannabis and Cannabinoid Research #Chemistry #Delta-9-tetrahydrocannabinol #Dronabinol #Epimer #Ether #Neurotransmitter Receptor Influence on Behavior #Organic chemistry #Pharmacology #Psychology #Stereochemistry #Substituent
- Stereochemical requirements for cannabinoid activity
1980/10/01 by Raphael Mechoulam, N. Lander, Tomas H. Varkony +5 · 1 citation
Chemistry · Medicine · #Analytical Chemistry and Chromatography #Biochemistry #Biological activity #Cannabinoid #Cannabis and Cannabinoid Research #Chemistry #In vitro #Molecular spectroscopy and chirality #Receptor #Stereochemistry #Substituent
- Comparative in vivo Metabolism of Δ1-tetrahydrocannabinol (Δ1-THC), cannabidiol (CBD) and cannabinol (CBN) by Several Species
1978/01/01 by D. J. Harvey, David J. Harvey, B R Martin +2 · 1 citation
Chemistry · Medicine · #Alcohol Consumption and Health Effects #Biochemistry #Biology #Cannabidiol #Cannabinoid #Cannabinol #Cannabis and Cannabinoid Research #Chemistry #Diet, Metabolism, and Disease #Enzyme #Glucuronide #Hydroxylation #In vivo #Metabolism #Stereochemistry #Tetrahydrocannabinol