- Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
2024/04/03 by Tina Baker, Hoda Sharifian, Paul J. Newcombe +23 · 27 citations
Immunology and Microbiology · Medicine · #Antibody #Blockade #Disease #Immunology #Interferon #Internal medicine #Lupus erythematosus #Medicine #Receptor #Rheumatoid Arthritis Research and Therapies #Systemic Lupus Erythematosus Research #Systemic lupus erythematosus #interferon and immune responses
- Engineering and Delivery of cGAS-STING Immunomodulators for the Immunotherapy of Cancer and Autoimmune Diseases
2023/10/06 by Shurong Zhou, Furong Cheng, Yu Zhang +2 · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Cancer immunotherapy #Cancer research #Chemistry #Cytomegalovirus and herpesvirus research #IRF3 #Immune system #Immunology #Immunotherapy #Innate immune system #Interferon #Medicine #Pharmacology #Stimulator of interferon genes #Sting #Virus-based gene therapy research #interferon and immune responses
- Ubiquitination network in the type I IFN‐induced antiviral signaling pathway
2023/05/17 by Qian Zhao, Renxia Zhang, Caixia Qiao +3 · 15 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Mathematics · Medicine · #Biology #Cell biology #Cytokine Signaling Pathways and Interactions #Effector #Gene #Genetics #Immunology #Innate immune system #Interferon #JAK-STAT signaling pathway #Janus kinase #NF-κB Signaling Pathways #Receptor #STAT protein #STAT3 #Signal transduction #Transcription factor #Tyrosine kinase #Ubiquitin #interferon and immune responses #stat
- Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
2022/10/06 by Aurélien Sokal, Paul Bastard, Pascal Chappert +64 · 25 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Autoantibody #B cell #Biology #Diabetes and associated disorders #Germinal center #Humoral immunity #Immune Cell Function and Interaction #Immunology #Interferon #Medicine #Memory B cell #SARS-CoV-2 and COVID-19 Research #Vaccination #Virology
- Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication
2020/12/24 by Andrea Marcellini, Dawid Swieboda, Anabel Guedán +7 · 12 citations
Immunology and Microbiology · Medicine · #Agonist #Asthma #Asthma and respiratory diseases #Budesonide #Fluticasone #Fluticasone propionate #Formoterol #Formoterol Fumarate #Glucocorticoid #Glucocorticoid receptor #IL-33, ST2, and ILC Pathways #Immune Cell Function and Interaction #Immunology #Interferon #Internal medicine #Medicine #Pharmacology #Receptor #Rhinovirus #Viral replication #Virus
- ImmGen report: sexual dimorphism in the immune system transcriptome
2019/09/20 by Shani T. Gal-Oz, Bárbara Maier, Hideyuki Yoshida +7 · 1 citation
Immunology and Microbiology · #Immune Cell Function and Interaction #Reproductive System and Pregnancy #T-cell and B-cell Immunology #Sexual dimorphism #Immune system #Biology #Innate immune system #Transcriptome #Interferon #Immunology #Gene #Sex characteristics #Gene expression profiling #Genetics #Gene expression #Zoology
- The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
2019/05/13 by Juli Bai, Feng Liu · 27 citations
Immunology and Microbiology · Medicine · #Apoptosis #Autophagy #Biology #Cell biology #Genetics #Immune system #Immunity #Immunology #Inflammation #Innate immune system #Insulin #Insulin resistance #Interferon #Metabolic pathway #Metabolism #Mosquito-borne diseases and control #PI3K/AKT/mTOR pathway #Signal transduction #Stimulator of interferon genes #Sting #Viral Infections and Vectors #interferon and immune responses #mTORC1
- Type I interferon induces CXCL13 to support ectopic germinal center formation
2019/02/05 by Alice E. Denton, Silvia Innocentin, Edward J. Carr +11 · 1 voice · 31 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #B cell #Biology #CXCL13 #Cell biology #Cell culture #Chemokine #Ectopic expression #Genetics #Germinal center #Immune Cell Function and Interaction #Immune Response and Inflammation #Immunology #Inflammasome and immune disorders #Inflammation #Interferon #Lymphatic system #Medicine #Population
- Tyrosine kinase 2 is not limiting human antiviral type III interferon responses
2016/09/12 by Sebastian Fuchs, Petra Kaiser‐Labusch, Julia Bank +5 · 26 citations
Immunology and Microbiology · #Biology #Cell biology #Cytokine #Immune Cell Function and Interaction #Immune Response and Inflammation #Immunology #Interferon #Interferon type I #Janus kinase #Janus kinase 1 #Platelet-derived growth factor receptor #Receptor #Signal transduction #T-cell and B-cell Immunology #Tyrosine kinase #Tyrosine kinase 2
- Influence of interferon-α on the expression of the cancer stem cell markers in pancreatic carcinoma cells
2014/04/13 by Yifan Zhu, Svetlana Karakhanova, Xiaolun Huang +3 · 16 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #CD24 #CD44 #Cancer #Cancer Cells and Metastasis #Cancer research #Cancer stem cell #Cancer, Hypoxia, and Metabolism #Cell #Cytokine #Immune cells in cancer #Immunology #In vivo #Interferon #Medicine #Metastasis #Pancreatic cancer #Population #Stem cell #Stem cell marker
- Degos Disease
2011/03/16 by Cynthia M. Magro, Jonathan C. Poe, Connie Kim +5 · 26 citations
Medicine · #Angiopathy #Diabetes mellitus #Gastrointestinal tract #Immunology #Interferon #Internal medicine #Medicine #Parvovirus B19 Infection Studies #Pathology #Systemic Lupus Erythematosus Research #Vascular disease #Viral Infections and Immunology Research
- 'The Impact of GSP on Developing Country Exports to the EU' Brighton: Department of Economics Working Paper, University of Sussex
2011/01/01 by Ellen F. Foxman, James A. Storer, Kiran Vanaja +5 · 2 citations
Economics, Econometrics and Finance · Medicine · #Apoptosis #Biology #Cell biology #Economic history #Economics #Genetics #Global trade and economics #Interferon #Political science #Respiratory viral infections research #Rhinovirus #Viral Infections and Vectors #Viral gastroenteritis research and epidemiology #Viral replication #Virology #Virus
- Genetic Dissection of Interferon-Antagonistic Functions of Rabies Virus Phosphoprotein: Inhibition of Interferon Regulatory Factor 3 Activation Is Important for Pathogenicity
2010/11/18 by Martina Rieder, Krzysztof Brzózka, Christian K. Pfaller +3 · 1 citation
Immunology and Microbiology · Medicine · #Rabies epidemiology and control #interferon and immune responses #Virology and Viral Diseases #Biology #IRF3 #IRF7 #Virology #Phosphoprotein #Interferon #Interferon regulatory factors #Rabies virus #Virus #Viral replication #Nucleoprotein #Molecular biology #Transcription factor #Phosphorylation #Gene #Cell biology #Genetics
- Roles for NK Cells and an NK Cell-Independent Source of Intestinal Gamma Interferon for Innate Immunity toCryptosporidium parvumInfection
2009/08/18 by Farah Barakat, Farah M. Barakat, Vincent McDonald +2 · 25 citations
Health Professions · Immunology and Microbiology · #Biology #Cryptosporidium #Cryptosporidium parvum #Feces #Immune Cell Function and Interaction #Immune system #Immunity #Immunology #Innate immune system #Innate lymphoid cell #Interferon #Interferon gamma #Microbiology #Parasitic Infections and Diagnostics #Pediatric health and respiratory diseases #Virology
- Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
2007/12/18 by Richard E. Randall, Stephen Goodbourn · 40 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Herpesvirus Infections and Treatments #Immune system #Immunology #Interferon #Mechanism (biology) #Virology #Virus #Virus-based gene therapy research #interferon and immune responses
- Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage
2007/03/12 by Claire Dunn, Maurizia Brunetto, Maurizia Rossana Brunetto +19 · 28 citations
Immunology and Microbiology · Medicine · #Apoptosis #Biology #Cytokine #Hepatitis B Virus Studies #Hepatitis B virus #Hepatocyte #Immune Cell Function and Interaction #Immune system #Immunology #In vitro #Inflammation #Innate immune system #Interferon #Interleukin #Tumor necrosis factor alpha #Viral gastroenteritis research and epidemiology #Virus
- Porcine Innate and Adaptative Immune Responses to Influenza and Coronavirus Infections
2006/10/01 by Bernard Charley, Sabine Riffault, Kristien Van Reeth · 1 citation
Agricultural and Biological Sciences · Medicine · Immunology and Microbiology · #Animal Virus Infections Studies #Influenza Virus Research Studies #Immunotherapy and Immune Responses #Virus #Immune system #Virology #Innate immune system #Biology #Immunology #Coronavirus #Vaccination #Interferon #Influenza A virus #Medicine #Infectious disease (medical specialty) #Coronavirus disease 2019 (COVID-19) #Disease
- Rabies Viral Mechanisms to Escape the IFN System: The Viral Protein P Interferes with IRF-3, Stat1, and PML Nuclear Bodies
2006/05/01 by Mounira K. Chelbi‐Alix, Aurore Vidy, Jamila El Bougrini +1 · 1 citation
Immunology and Microbiology · Medicine · #interferon and immune responses #Viral Infections and Vectors #Herpesvirus Infections and Treatments #STAT1 #Interferon #Biology #Promyelocytic leukemia protein #Virology #Nuclear transport #Viral replication #Phosphorylation #Interferon regulatory factors #Antiviral protein #Nuclear protein #Gene #Cell biology #RNA #Transcription factor #Virus #Cytoplasm #Cell nucleus #Genetics
- Antiviral therapy of HCV in the cirrhotic and transplant candidate
2006/01/01 by Steven K. Herrine, Victor J. Navarro · 1 citation
Medicine · #Hepatitis C virus research #Hepatitis B Virus Studies #Liver Disease Diagnosis and Treatment #Medicine #Hepatocellular carcinoma #Cirrhosis #Regimen #Antiviral therapy #Liver transplantation #Liver disease #Internal medicine #Interferon #Hepatitis C #Intensive care medicine #Transplantation #Gastroenterology #Oncology #Immunology #Chronic hepatitis #Virus
- Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
2005/07/04 by Frank O. Nestlé, Frank O. Nestle, Curdin Conrad +8 · 37 citations
Immunology and Microbiology · Medicine · #Alpha interferon #Biology #Dendritic cell #Immune system #Immunology #Immunotherapy and Immune Responses #Innate immune system #Interferon #Interferon gamma #Interferon type I #Medicine #Plasmacytoid dendritic cell #Psoriasis #Psoriasis: Treatment and Pathogenesis #T-cell and B-cell Immunology
- Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes
2004/08/09 by Victoria Auerbuch, Dirk G. Brockstedt, Nicole Meyer-Morse +2 · 1 citation
Immunology and Microbiology · Medicine · Veterinary · #Bacteria #Biology #Cell biology #Cytokine #Cytokine Signaling Pathways and Interactions #Immune Response and Inflammation #Immune system #Immunity #Immunology #In vivo #Interferon #Interferon gamma #Interferon type I #Intracellular #Intracellular parasite #Listeria monocytogenes #Microbiology #Spleen #Tumor necrosis factor alpha #Veterinary medicine and infectious diseases
- Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
2001/09/01 by Michael P Manns, Michael P. Manns, John G. McHutchison +15 · 2 citations
Medicine · #Alpha interferon #Chronic hepatitis #Gastroenterology #Hepatitis B Virus Studies #Hepatitis C #Hepatitis C virus #Hepatitis C virus research #Hepatitis Viruses Studies and Epidemiology #Immunology #Interferon #Interferon alfa #Internal medicine #Medicine #Peginterferon alfa-2a #Ribavirin #Virus
- A Subcutaneous Delta-Positive T-Cell Lymphoma That Produces Interferon Gamma
1991/10/10 by Günter Burg, Reinhard Dummer, Martin Wilhelm +7 · 2 citations
Immunology and Microbiology · Medicine · #Antigen #Biology #CD3 #CD30 #CD5 #CD8 #Chemotherapy #Cutaneous lymphoproliferative disorders research #Immune Cell Function and Interaction #Immune system #Immunology #Interferon #Internal medicine #Leukopenia #Lymphoma #Medicine #Natural killer T cell #Pathology #Peripheral blood mononuclear cell #T cell #T-cell and Retrovirus Studies
- Molecular analysis of a human interferon‐inducible gene family
1991/07/01 by Andrew R. LEWIN, Andrew R. Lewin, Laurence E. Reid +7 · 26 citations
Immunology and Microbiology · Medicine · #Biology #Computational biology #Cytokine Signaling Pathways and Interactions #Gene #Genetics #Interferon #Monoclonal and Polyclonal Antibodies Research #interferon and immune responses