1991/10/10 by Günter Burg, Reinhard Dummer, Martin Wilhelm +7 · 2 citations
Immunology and Microbiology · Medicine · #Antigen #Biology #CD3 #CD30 #CD5 #CD8 #Chemotherapy #Cutaneous lymphoproliferative disorders research #Immune Cell Function and Interaction #Immune system #Immunology #Interferon #Internal medicine #Leukopenia #Lymphoma #Medicine #Natural killer T cell #Pathology #Peripheral blood mononuclear cell #T cell #T-cell and Retrovirus Studies
paper · pdf · doi:10.1056/nejm199110103251506
openalex publication_date 1991/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
WE report an unusual form of cutaneous T-cell lymphoma characterized by subcutaneous tumors that regress spontaneously, fever, progressive leukopenia, high levels of interferon gamma in the serum, and an increased natural-killer-cell activity of peripheral-blood mononuclear cells. Histologically, the infiltrate consists of nonepidermotropic, pleomorphic lymphoid cells located in the subcutaneous fatty tissue. These cells express the phenotype of immature (CD1+, CD3+, CD4-, CD5-, CD8-), activated (CD30+, CD25+, HLA-DR+) T cells positive for delta T-cell receptors. They express the natural-killer-cell phenotype (CD56+) and produce interferon gamma in cell culture. Case Report A 70-year-old woman presented in March 1985 with recurrent, spontaneously regressing, . . .