1. CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice
   2023/10/04 by Angela J. T. Bosch, Lena Keller, Laura Steiger +16 · 17 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adipokines, Inflammation, and Metabolic Diseases #Biochemistry #Biology #Cell biology #Cytokine #Downregulation and upregulation #Endocrinology #Glucose homeostasis #Immune cells in cancer #Immune system #Immunology #In vitro #Insulin #Insulin resistance #Internal medicine #Islet #Macrophage #Medicine #Metabolism, Diabetes, and Cancer #Secretagogue #Secretion
2. Interorgan crosstalk in pancreatic islet function and pathology
   2022/01/11 by Ronald M. Evans, Zong Wei · 12 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biology #Cell biology #Chemistry #Crosstalk #Diabetes Treatment and Management #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Function (biology) #Internal medicine #Islet #Medicine #Optics #Pancreas #Pancreatic function #Pancreatic function and diabetes #Pancreatic islets #Pathology #Physics
3. Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction
   2021/11/09 by Li Xiong, Li Chen, Liting Wu +9 · 20 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biochemistry #Biology #Cancer-related molecular mechanisms research #Cell biology #Circular RNAs in diseases #Diabetes mellitus #Endocrinology #Endoplasmic Reticulum Stress and Disease #Exosome #Insulin resistance #Internal medicine #Islet #Lipotoxicity #Medicine #Microvesicles #microRNA
4. Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
   2020/09/07 by Nathalie Esser, Kristina M. Utzschneider, Steven E. Kahn · 34 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #BETA (programming language) #Beta cell #Bioinformatics #Biology #Context (archaeology) #Diabetes mellitus #Diet, Metabolism, and Disease #Endocrinology #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Pathogenesis #Type 2 diabetes
5. Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion
   2020/08/27 by Weiwei Xu, Lina Schiffer, Mirza Muhammad Fahd Qadir +11 · 10 citations
   Medicine · #Androgen #Aromatase #Biology #Dihydrotestosterone #Endocrinology #Hormonal Regulation and Hypertension #Hormonal and reproductive studies #Hormone #Insulin #Internal medicine #Intracrine #Islet #Medicine #Pancreatic function and diabetes #Pancreatic islets #Paracrine signalling #Receptor #Testosterone (patch)
6. Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells
   2020/03/31 by Siming Liu, Joseph A. Promes, Mikako Harata +8 · 18 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Adipose Tissue and Metabolism #Adipose tissue #Adipose triglyceride lipase #Biology #Cell biology #Chemistry #Endocannabinoid system #Endocrinology #Insulin #Internal medicine #Islet #Lipid droplet #Lipid metabolism and biosynthesis #Lipolysis #Medicine #Monoacylglycerol lipase #Pancreatic function and diabetes
7. Use of Streptozotocin in Rodent Models of Islet Transplantation
   2020/01/01 by Aileen King, Aileen J. F. King, Elisabet Estil·les +1 · 1 citation
   Medicine · #Beta cell #Biology #Cannabis and Cannabinoid Research #Diabetes Management and Research #Diabetes mellitus #Endocrinology #Glycemic #Internal medicine #Islet #Kidney #Medicine #Pancreatic function and diabetes #Rodent #Streptozotocin #Transplantation
8. Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes
   2019/12/09 by Tong Sun, Xiao Han · 1 citation
   Biochemistry, Genetics and Molecular Biology · Medicine · #BETA (programming language) #Beta cell #Bioinformatics #Biology #Computer science #Diabetes and associated disorders #Diabetes mellitus #Disease #Endocrinology #Glucose homeostasis #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Type 2 diabetes
9. microRNA-375 regulates glucose metabolism-related signaling for insulin secretion
   2019/11/07 by Olivier Dumortier, Gaia Fabris, Didier F Pisani +13 · 19 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biology #Carbohydrate metabolism #Endocrinology #Glucose homeostasis #Glycolysis #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism #MicroRNA in disease regulation #Pancreatic function and diabetes #RNA modifications and cancer #Secretion
10. Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice
    2019/09/20 by Jian Ma, Xin He, Yan Cao +10 · 10 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biology #Cancer-related gene regulation #Cell biology #Chromatin #Endocrinology #Epigenetics and DNA Methylation #Gene #Gene expression #Genetics #Glucose homeostasis #Histone #Histone methyltransferase #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Methylation #Methyltransferase #Pancreatic function and diabetes #Protein arginine methyltransferase 5
11. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis
    2019/02/13 by Andrew W. Norris, Andrew W Norris, Katie Larson Ode +8 · 27 citations
    Medicine · #Cystic Fibrosis Research Advances #Cystic fibrosis #Cystic fibrosis transmembrane conductance regulator #Cystic fibrosis-related diabetes #Diabetes mellitus #Endocrinology #Fibrosis #Impaired glucose tolerance #Inflammation #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Pediatric Hepatobiliary Diseases and Treatments #Type 2 diabetes
12. Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
    2018/12/12 by Michael R. Rickels, R. Paul Robertson · 1 citation
    Medicine · #Pancreatic function and diabetes #Diabetes Management and Research #Cannabis and Cannabinoid Research #Transplantation #Islet #Medicine #Pancreas transplantation #Pancreas #Diabetes mellitus #Islet cell transplantation #Hypoglycemia #Pancreatitis #Type 1 diabetes #Insulin #Glycemic #Internal medicine #Endocrinology #Kidney transplantation
13. Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk
    2018/06/21 by the Type 1 Diabetes TrialNet Study Group, Mustafa Tosur, Susan M. Geyer +6 · 24 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Autoimmunity #Biology #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Disease #Endocrinology #Ethnic group #Genetics #Human physiology #Immunology #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Sociology #Type 1 diabetes #Type 2 diabetes
14. Alpha cell dysfunction in type 1 diabetes
    2018/02/01 by Gina L. C. Yosten, Gina L.C. Yosten · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · #Alpha (finance) #Alpha cell #Beta cell #Biology #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Glucagon #Glucose homeostasis #Hyperglucagonemia #Hypoglycemia #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Type 1 diabetes #Type 2 diabetes
15. Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets
    2017/06/06 by Matthew J. Westacott, Nikki L. Farnsworth, Joshua R. St. Clair +8 · 25 citations
    Medicine · #Adipose Tissue and Metabolism #Biology #Cannabis and Cannabinoid Research #Cell biology #Diabetes mellitus #Endocrinology #Gap junction #Insulin #Insulin oscillation #Internal medicine #Intracellular #Islet #Medicine #Pancreatic function and diabetes #Pancreatic islets #Secretion #Type 2 diabetes
16. Increased vimentin in human α- and β-cells in type 2 diabetes
    2017/03/27 by Maaike M Roefs, Maaike M. Roefs, Françoise Carlotti +21 · 22 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Glucagon #Immunohistochemistry #Insulin #Internal medicine #Islet #Medicine #Mesenchymal stem cell #Metabolism, Diabetes, and Cancer #PDX1 #Pancreas #Pancreatic function and diabetes #Pathology #Vimentin
17. Clinical pancreatic islet transplantation
    2016/11/11 by A. M. James Shapiro, Marta Pokrywczyńska, Marta Pokrywczynska +1 · 1 citation
    Medicine · #Cannabis and Cannabinoid Research #Diabetes Management and Research #Diabetes mellitus #Endocrinology #Immunosuppression #Intensive care medicine #Internal medicine #Islet #Islet cell transplantation #Medicine #Pancreatic function and diabetes #Transplantation #Type 1 diabetes #Type 2 Diabetes Mellitus
18. Early sympathetic islet neuropathy in autoimmune diabetes: lessons learned and opportunities for investigation
    2016/06/24 by Thomas O. Mundinger, Gerald J. Taborsky · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Biology #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Immune system #Immunology #Insulitis #Internal medicine #Islet #Medicine #Neuroscience #Pancreatic function and diabetes #Type 1 diabetes
19. Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves
    2016/05/13 by Thomas O. Mundinger, Qi Mei, Alan K. Foulis +3 · 2 citations
    Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes Management and Research #Diabetes and associated disorders #Internal medicine #Medicine #Endocrinology #Diabetes mellitus #Islet #Type 1 diabetes #Sympathetic nervous system #Glucagon #Type 2 diabetes #Hypoglycemia #Pancreas #Autonomic nervous system #Insulin #Blood pressure #Heart rate
20. Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets
    2015/10/16 by Ksenia Tugay, Claudiane Guay, Ana C. Marques +6 · 21 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Ageing #BETA (programming language) #Beta cell #Biology #Diabetes and associated disorders #Downregulation and upregulation #Endocrinology #Gene #Gene expression #Genetics #Insulin #Internal medicine #Islet #Medicine #MicroRNA in disease regulation #Microarray #Microarray analysis techniques #Pancreatic function and diabetes #Pancreatic islets #Transcriptome #microRNA
21. Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase
    2015/07/27 by Teresa Rodríguez-Calvo, Teresa Rodriguez-Calvo, Jessica S. Suwandi +6 · 25 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Antibody #Antigen #Autoantibody #Beta cell #Biology #CD8 #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Immunology #Inflammation #Insulitis #Internal medicine #Islet #Major histocompatibility complex #Medicine #Pancreas #Pancreatic function and diabetes #Pancreatic islets #Pathology #Type 1 diabetes
22. Calcium release channel RyR2 regulates insulin release and glucose homeostasis
    2015/04/05 by Gaetano Santulli, Gennaro Pagano, Celestino Sardu +9 · 2 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Calcium #Calcium metabolism #Cardiac electrophysiology and arrhythmias #Catecholaminergic polymorphic ventricular tachycardia #Cell biology #Endocrinology #Endoplasmic reticulum #Glucose homeostasis #Homeostasis #Insulin #Insulin resistance #Internal medicine #Ion channel regulation and function #Islet #Medicine #Pancreatic function and diabetes #Pancreatic islets #Ryanodine receptor #Ryanodine receptor 2 #Unfolded protein response
23. Human Islet Morphology Revisited
    2015/01/20 by Susan Bonner-Weir, Susan Bonner‐Weir, Brooke A. Sullivan +1 · 27 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Internal medicine #Islet #Medicine #Pancreas #Pancreatic function and diabetes
24. Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens
    2014/09/03 by Sonja Kleffel, Andrea Vergani, Sara Tezza +17 · 25 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Antigen #B cell #Biology #CD40 #Cytotoxic T cell #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Genetics #Immune tolerance #Immunology #Islet #Pancreatic function and diabetes #Regulatory B cells #T-cell and B-cell Immunology
25. The use of animal models in diabetes research
    2012/02/21 by Aileen King · 3 citations
    Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes and associated disorders #Diabetes Management and Research #Diabetes mellitus #Type 2 diabetes #Insulin resistance #Medicine #Beta cell #Type 1 diabetes #Insulin #Internal medicine #Pancreas #BETA (programming language) #Endocrinology #Animal model #Computer science #Islet
26. Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
    2011/08/23 by F. Fiory, Francesca Fiory, Assunta Lombardi +9 · 27 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Advanced Glycation End Products research #Aldose Reductase and Taurine #Beta cell #Biochemistry #Biology #Chemistry #Endocrinology #Enzyme #Glucose uptake #Glycogen synthase #Insulin #Insulin receptor #Insulin resistance #Internal medicine #Islet #Medicine #Methylglyoxal #Pancreatic function and diabetes #Protein kinase B #Receptor #Signal transduction #Tyrosine phosphorylation
27. Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death
    2009/10/29 by Junqin Chen, Ghislaine Fontes, Ghislaine Fontès +3 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Beta cell #Biochemistry #Biology #Cell biology #Chemistry #Diabetes and associated disorders #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Insulin #Internal medicine #Islet #Medicine #Oxidative stress #Programmed cell death #Redox biology and oxidative stress #TXNIP #Thioredoxin #Unfolded protein response
28. Central amylin expression and its induction in rat dams
    2009/10/07 by Árpád Dobolyi, Arpád Dobolyi · 27 citations
    Chemistry · Medicine · Neuroscience · Psychology · #Amylin #Biology #Chemistry #Endocrinology #Gene #Gene expression #Hypothalamus #In situ hybridization #Insulin #Internal medicine #Islet #Medicine #Neuroendocrine regulation and behavior #Neuropeptide #Neuropeptides and Animal Physiology #Preoptic area #Receptor #Regulation of Appetite and Obesity #Stria terminalis
29. β-Cell–Mediated Signaling Predominates Over Direct α-Cell Signaling in the Regulation of Glucagon Secretion in Humans
    2009/09/03 by Benjamin A. Cooperberg, Philip E. Cryer · 1 citation
    Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes Treatment and Management #Diabetes and associated disorders #Endocrinology #Internal medicine #Glucagon #Alpha cell #Glimepiride #Medicine #Hypoglycemia #Sulfonylurea #Secretion #Beta cell #Diabetes mellitus #Alpha (finance) #Glucagon-like peptide-1 #Type 2 diabetes #Insulin #Islet
30. Sequence and Crowding Effects in the Aggregation of a 10-Residue Fragment Derived from Islet Amyloid Polypeptide
    2009/05/29 by Eva Rivera, John Straub, John E. Straub +1 · 13 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alzheimer's disease research and treatments #Amylin #Amyloid (mycology) #Amyloid fibril #Amyloid β #Biochemistry #Biology #Biophysics #Chemistry #Context (archaeology) #Crystallography #Dimer #Fibril #Insulin #Islet #Molecular dynamics #Nucleation #Peptide #Peptide sequence #Prion Diseases and Protein Misfolding #Protein Structure and Dynamics #Sequence (biology)

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