- Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction
2021/11/09 by Li Xiong, Li Chen, Liting Wu +9 · 20 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biochemistry #Biology #Cancer-related molecular mechanisms research #Cell biology #Circular RNAs in diseases #Diabetes mellitus #Endocrinology #Endoplasmic Reticulum Stress and Disease #Exosome #Insulin resistance #Internal medicine #Islet #Lipotoxicity #Medicine #Microvesicles #microRNA
- Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
2020/09/07 by Nathalie Esser, Kristina M. Utzschneider, Steven E. Kahn · 34 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #BETA (programming language) #Beta cell #Bioinformatics #Biology #Context (archaeology) #Diabetes mellitus #Diet, Metabolism, and Disease #Endocrinology #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Pathogenesis #Type 2 diabetes
- Use of Streptozotocin in Rodent Models of Islet Transplantation
2020/01/01 by Aileen King, Aileen J. F. King, Elisabet Estil·les +1 · 1 citation
Medicine · #Beta cell #Biology #Cannabis and Cannabinoid Research #Diabetes Management and Research #Diabetes mellitus #Endocrinology #Glycemic #Internal medicine #Islet #Kidney #Medicine #Pancreatic function and diabetes #Rodent #Streptozotocin #Transplantation
- Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes
2019/12/09 by Tong Sun, Xiao Han · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #BETA (programming language) #Beta cell #Bioinformatics #Biology #Computer science #Diabetes and associated disorders #Diabetes mellitus #Disease #Endocrinology #Glucose homeostasis #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Type 2 diabetes
- microRNA-375 regulates glucose metabolism-related signaling for insulin secretion
2019/11/07 by Olivier Dumortier, Gaia Fabris, Didier F Pisani +13 · 19 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biology #Carbohydrate metabolism #Endocrinology #Glucose homeostasis #Glycolysis #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Metabolism #MicroRNA in disease regulation #Pancreatic function and diabetes #RNA modifications and cancer #Secretion
- Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice
2019/09/20 by Jian Ma, Xin He, Yan Cao +10 · 10 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Beta cell #Biology #Cancer-related gene regulation #Cell biology #Chromatin #Endocrinology #Epigenetics and DNA Methylation #Gene #Gene expression #Genetics #Glucose homeostasis #Histone #Histone methyltransferase #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Methylation #Methyltransferase #Pancreatic function and diabetes #Protein arginine methyltransferase 5
- Alpha cell dysfunction in type 1 diabetes
2018/02/01 by Gina L. C. Yosten, Gina L.C. Yosten · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Alpha (finance) #Alpha cell #Beta cell #Biology #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Glucagon #Glucose homeostasis #Hyperglucagonemia #Hypoglycemia #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Type 1 diabetes #Type 2 diabetes
- Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets
2015/10/16 by Ksenia Tugay, Claudiane Guay, Ana Claudia Marques +6 · 21 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Ageing #BETA (programming language) #Beta cell #Biology #Diabetes and associated disorders #Downregulation and upregulation #Endocrinology #Gene #Gene expression #Genetics #Insulin #Internal medicine #Islet #Medicine #MicroRNA in disease regulation #Microarray #Microarray analysis techniques #Pancreatic function and diabetes #Pancreatic islets #Transcriptome #microRNA
- Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase
2015/07/27 by Teresa Rodriguez-Calvo, Teresa Rodríguez-Calvo, Jessica S. Suwandi +6 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibody #Antigen #Autoantibody #Beta cell #Biology #CD8 #Diabetes Management and Research #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Immunology #Inflammation #Insulitis #Internal medicine #Islet #Major histocompatibility complex #Medicine #Pancreas #Pancreatic function and diabetes #Pancreatic islets #Pathology #Type 1 diabetes
- The use of animal models in diabetes research
2012/02/21 by Aileen King · 3 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes and associated disorders #Diabetes Management and Research #Diabetes mellitus #Type 2 diabetes #Insulin resistance #Medicine #Beta cell #Type 1 diabetes #Insulin #Internal medicine #Pancreas #BETA (programming language) #Endocrinology #Animal model #Computer science #Islet
- Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
2011/08/23 by Francesca Fiory, F. Fiory, A. Lombardi +9 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Advanced Glycation End Products research #Aldose Reductase and Taurine #Beta cell #Biochemistry #Biology #Chemistry #Endocrinology #Enzyme #Glucose uptake #Glycogen synthase #Insulin #Insulin receptor #Insulin resistance #Internal medicine #Islet #Medicine #Methylglyoxal #Pancreatic function and diabetes #Protein kinase B #Receptor #Signal transduction #Tyrosine phosphorylation
- Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death
2009/10/29 by Junqin Chen, Ghislaine Fontes, Ghislaine Fontès +3 · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Beta cell #Biochemistry #Biology #Cell biology #Chemistry #Diabetes and associated disorders #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Insulin #Internal medicine #Islet #Medicine #Oxidative stress #Programmed cell death #Redox biology and oxidative stress #TXNIP #Thioredoxin #Unfolded protein response
- β-Cell–Mediated Signaling Predominates Over Direct α-Cell Signaling in the Regulation of Glucagon Secretion in Humans
2009/09/03 by Benjamin A. Cooperberg, Philip E. Cryer · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes Treatment and Management #Diabetes and associated disorders #Endocrinology #Internal medicine #Glucagon #Alpha cell #Glimepiride #Medicine #Hypoglycemia #Sulfonylurea #Secretion #Beta cell #Diabetes mellitus #Alpha (finance) #Glucagon-like peptide-1 #Type 2 diabetes #Insulin #Islet
- Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
2008/07/31 by Iván Quesada, Ivan Quesada, Eva Tudurí +3 · 32 citations
Medicine · #Alpha cell #Beta cell #Biochemistry #Biology #Blood sugar regulation #Carbohydrate metabolism #Cell #Cell physiology #Diabetes Management and Research #Diabetes Treatment and Management #Diabetes mellitus #Endocrinology #Glucagon #Glucose homeostasis #Homeostasis #Hormone #Insulin #Insulin resistance #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Paracrine signalling #Receptor
- Too Much Glucagon, Too Little Insulin
2008/07/01 by Rebecca J. Brown, Ninet Sinaii, Kristina I. Rother · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Diabetes and associated disorders #Pancreatic function and diabetes #Diabetes Management and Research #Hyperglucagonemia #Glucagon #Medicine #Internal medicine #Postprandial #Endocrinology #Alpha cell #Diabetes mellitus #Insulin #Type 1 diabetes #Type 2 diabetes #Glucagon-like peptide-1 #Beta cell #Islet
- The mechanisms of alloxan- and streptozotocin-induced diabetes
2007/12/17 by Sigurd Lenzen, S. Lenzen · 37 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alloxan #Beta cell #Biochemistry #Biology #Carbohydrate metabolism #Chemistry #Diabetes mellitus #Diet, Metabolism, and Disease #Endocrinology #GLUT2 #Glucokinase #Glucose transporter #Glutathione #Insulin #Internal medicine #Islet #Medicine #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes #Reactive oxygen species #Streptozotocin
- High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes
2007/07/27 by Chang-jiang Huang, Chia-yu Lin, Chia‐Yu Lin +5 · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Beta cell #Biochemistry #Biology #CHOP #Cell biology #Diabetes and associated disorders #Diabetes mellitus #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Unfolded protein response
- Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
2007/02/01 by D. Ross Laybutt, D. R. Laybutt, A. M. Preston +10 · 34 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Beta cell #Biochemistry #Biology #Cell biology #Diabetes and associated disorders #Downregulation and upregulation #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Gene #Heat shock protein #Insulin #Internal medicine #Islet #Medicine #Pancreatic function and diabetes #Pancreatic islets #Programmed cell death #Unfolded protein response #XBP1
- Exposure to Chronic High Glucose Induces β-Cell Apoptosis Through Decreased Interaction of Glucokinase With Mitochondria
2005/09/01 by Won-Ho Kim, Won–Ho Kim, June Woo Lee +7 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Apoptosome #Autophagy in Disease and Therapy #Beta cell #Biochemistry #Biology #Caspase #Cell biology #Cell culture #Cytochrome c #Endocrinology #Glucokinase #Glycolysis #Hexokinase #Insulin #Internal medicine #Islet #Medicine #Metabolism #Metabolism, Diabetes, and Cancer #Mitochondrion #Pancreatic function and diabetes #Programmed cell death #Transfection
- The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus
2001/09/01 by Sigurd Lenzen, S. Lenzen, M. Tiedge +17 · 6 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Autoimmune disease #Autoimmunity #Beta cell #Diabetes and associated disorders #Diabetes mellitus #Disease #Endocrinology #Glycosuria #Immunology #Insulin #Insulitis #Internal medicine #Islet #Ketonuria #Medicine #Pancreatic function and diabetes #Polyuria #T-cell and B-cell Immunology #Type 1 diabetes
- Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*
1990/07/01 by Jun‐ichi Miyazaki, JUN-ICHI MIYAZAKI, KIMI ARAKI +13 · 30 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antigen #Beta cell #Biochemistry #Biology #Cell #Cell culture #Diabetes Management and Research #Diabetes and associated disorders #Endocrinology #Glucose transporter #Immunology #Insulin #Internal medicine #Islet #MHC class I #Major histocompatibility complex #Medicine #Pancreatic function and diabetes #Secretion