Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007/02/01 by D. Ross Laybutt, D. R. Laybutt, Amanda M. Preston +10 · 31 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Endoplasmic Reticulum Stress and Disease #Pancreatic function and diabetes #Diabetes and associated disorders

paper · pdf · doi:10.1007/s00125-006-0590-z

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• Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
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• Activating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival
• Endoplasmic reticulum stress in disease pathogenesis. [europepmc]
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• Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. [europepmc]
• Beta-cell failure as a complication of diabetes. [europepmc]
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• Glucolipotoxicity of the pancreatic beta cell. [europepmc]
• Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. [europepmc]
• Endoplasmic reticulum stress and pancreatic β-cell death. [europepmc]
• Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. [europepmc]
• Role of endoplasmic reticulum stress in metabolic disease and other disorders. [europepmc]
• Endoplasmic reticulum stress and type 2 diabetes. [europepmc]
• The impact of the unfolded protein response on human disease. [europepmc]
• Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. [europepmc]
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• Recent advances in understanding the anti-diabetic actions of dietary flavonoids. [europepmc]
• Signaling pathways from the endoplasmic reticulum and their roles in disease. [europepmc]
• The role of endoplasmic reticulum stress in human pathology. [europepmc]
• Natural history of β-cell adaptation and failure in type 2 diabetes. [europepmc]
• Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. [europepmc]
• Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction. [europepmc]
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• GRP78 at the Centre of the Stage in Cancer and Neuroprotection. [europepmc]
• Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes. [europepmc]
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• A guide to understanding endoplasmic reticulum stress in metabolic disorders. [europepmc]