Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

2011/03/03 by Lale Ozcan, Lale Özcan, Ira Tabas · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Endoplasmic Reticulum Stress and Disease #Pancreatic function and diabetes #Autophagy in Disease and Therapy

paper · doi:10.1146/annurev-med-043010-144749

Abstract

Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress.

Citations

• Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

Cited by

• Navigating Misfolded Terrain: ER-Associated Degradation of Membrane Proteins
• Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

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