Peter K. Sorger

1. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
   2020/12/01 by Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker +20 · 14 citations
   Medicine · Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Adipose Tissue and Metabolism #Cancer, Hypoxia, and Metabolism #Immune cells in cancer
2. Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death
   2008/11/26 by John G. Albeck, John M. Burke, Sabrina L. Spencer +2 · 6 citations
   Biochemistry, Genetics and Molecular Biology · #Cell death mechanisms and regulation #RNA Interference and Gene Delivery #ATP Synthase and ATPases Research
3. Dissecting Variability in Responses to Cancer Chemotherapy Through Systems Pharmacology
   2010/06/02 by R Yang, Robert Yang, Mario Niepel +5 · 27 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Cancer #Cancer Genomics and Diagnostics #Cancer chemotherapy #Chemotherapy #Internal medicine #Medicine #Monoclonal and Polyclonal Antibodies Research #Pharmacogenetics and Drug Metabolism #Pharmacology
4. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
   2018/07/11 by Jia‐Ren Lin, Benjamin Izar, Shu Wang +5 · 6 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Advanced Fluorescence Microscopy Techniques #Immunotherapy and Immune Responses #Single-cell and spatial transcriptomics
5. Metrics other than potency reveal systematic variation in responses to cancer drugs
   2013/09/08 by Mohammad Fallahi-Sichani, Mohammad Fallahi‐Sichani, Saman Honarnejad +6 · 4 citations
   Biochemistry, Genetics and Molecular Biology · Computer Science · #Cancer therapeutics and mechanisms #Computational Drug Discovery Methods #Receptor Mechanisms and Signaling
6. Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy
   2017/12/01 by Adam C. Palmer, Peter K. Sorger · 3 citations
   Computer Science · Mathematics · Pharmacology, Toxicology and Pharmaceutics · #Computational Drug Discovery Methods #Mathematical Biology Tumor Growth #Pharmacogenetics and Drug Metabolism
7. Programming biological models in Python using PySB
   2013/02/19 by Carlos F. Lopez, Jeremy L. Muhlich, John A. Bachman +1 · 3 citations
   Biochemistry, Genetics and Molecular Biology · #Gene Regulatory Network Analysis #Protein Structure and Dynamics #Microbial Metabolic Engineering and Bioproduction
8. Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2
   2000/06/01 by Max Dobles, Vasco Liberal, Martin L Scott +3 · 3 citations
   Biochemistry, Genetics and Molecular Biology · #DNA Repair Mechanisms #Genomics and Chromatin Dynamics #Microtubule and mitosis dynamics
9. A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis
   2005/12/08 by Kevin A. Janes, John G. Albeck, Suzanne Gaudet +3 · 4 citations
   Computer Science · Biochemistry, Genetics and Molecular Biology · #Computational Drug Discovery Methods #Receptor Mechanisms and Signaling #Protein Kinase Regulation and GTPase Signaling
10. Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation
    1997/11/01 by Kenneth B Kaplan, Kenneth B. Kaplan, Anthony A Hyman +3 · 2 citations
    Biochemistry, Genetics and Molecular Biology · #Fungal and yeast genetics research #Microtubule and mitosis dynamics
11. The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade
    2006/03/01 by Kevin A. Janes, Suzanne Gaudet, John G. Albeck +3 · 2 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Cell Adhesion Molecules Research #Glycosylation and Glycoproteins Research #Proteoglycans and glycosaminoglycans research
12. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    2009/04/12 by Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck +2 · 2 citations
    Biochemistry, Genetics and Molecular Biology · #CRISPR and Genetic Engineering #Cell Image Analysis Techniques #Cell death mechanisms and regulation
13. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
    2016/05/02 by Marc Hafner, Mario Niepel, Mirra Chung +2 · 3 citations
    Biochemistry, Genetics and Molecular Biology · Computer Science · #Computational Drug Discovery Methods #Genomics and Chromatin Dynamics #Protein Degradation and Inhibitors
14. Multi-Modal Foundation Models for Computational Pathology: A Survey
    2025/03/12 by Dong Li, Li, Dong, Guihong Wan +17 · 4 citations
    Computer Science · Medicine · #AI in cancer detection #Artificial Intelligence (cs.AI) #Computer Vision and Pattern Recognition (cs.CV) #FOS: Computer and information sciences #Medical Image Segmentation Techniques #Radiomics and Machine Learning in Medical Imaging
15. Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
    2019/06/06 by Marc Hafner, Caitlin E. Mills, Kartik Subramanian +8 · 2 citations
    Medicine · #Advanced Breast Cancer Therapies #Biology #Breast cancer #CDK inhibitor #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell cycle #Chronic Lymphocytic Leukemia Research #Computational biology #Cyclin-dependent kinase #Cyclin-dependent kinase 1 #Cyclin-dependent kinase 2 #Cyclin-dependent kinase 4 #Genetics #Internal medicine #Kinase #Medicine #Metastatic breast cancer #Palbociclib #Pharmacology #Protein kinase A
16. Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
    2024/12/20 by Tanjina Kader, Jia‐Ren Lin, Clemens B. Hug +26 · 2 voices · 18 citations
    Medicine · Biochemistry, Genetics and Molecular Biology · #Ovarian cancer diagnosis and treatment #Single-cell and spatial transcriptomics #Ferroptosis and cancer prognosis
17. MITI Minimum Information guidelines for highly multiplexed tissue images
    2021/08/21 by Denis Schapiro, Schapiro, Denis, Clarence Yapp +84 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Cancer Genomics and Diagnostics #Radiomics and Machine Learning in Medical Imaging #Single-cell and spatial transcriptomics #eess.IV #q-bio.OT
18. A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines
    2019/07/01 by Mario Niepel, Marc Hafner, Caitlin E. Mills +32 · 2 citations
    Biochemistry, Genetics and Molecular Biology · Computer Science · #Cell Image Analysis Techniques #Computational Drug Discovery Methods #Advanced Biosensing Techniques and Applications
19. Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
    2021/01/21 by Avilash Cramer, Deborah Plana, Helen Yang +13 · 2 citations
    Immunology and Microbiology · Medicine · #Medical Device Sterilization and Disinfection #Infection Control and Ventilation
20. Molecular Analysis of Kinetochore-Microtubule Attachment in Budding Yeast
    2001/07/01 by Xiangwei He, Daniel R Rines, Daniel R. Rines +4 · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Fungal and yeast genetics research #Genomics and Chromatin Dynamics #Microtubule and mitosis dynamics
21. Cancer patient survival can be accurately parameterized, revealing time-dependent therapeutic effects and doubling the precision of small trials
    2021/05/17 by Deborah Plana, Geoffrey Fell, Brian M. Alexander +2 · 1 citation
    Mathematics · Economics, Econometrics and Finance · Biochemistry, Genetics and Molecular Biology · #Statistical Methods in Clinical Trials #Health Systems, Economic Evaluations, Quality of Life #Cancer Genomics and Diagnostics
22. Biophysical prediction of protein–peptide interactions and signaling networks using machine learning
    2020/01/06 by Joseph M. Cunningham, Julia R. Rogers, Grigoriy Koytiger +2 · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Machine Learning in Bioinformatics #Protein Structure and Dynamics #RNA and protein synthesis mechanisms
23. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
    1988/09/01 by Peter K. Sorger, Hugh R.B. Pelham · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Environmental Science · #Heat shock proteins research #Physiological and biochemical adaptations #thermodynamics and calorimetric analyses
24. A Crisis-Responsive Framework for Medical Device Development during the COVID-19 Pandemic
    2020/09/24 by Marc‐Joseph Antonini, Deborah Plana, Shriya S. Srinivasan +10 · 1 citation
    Economics, Econometrics and Finance · Medicine · Health Professions · #Health Systems, Economic Evaluations, Quality of Life #Biomedical Ethics and Regulation #Healthcare cost, quality, practices
25. Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data
    2021/11/08 by Rumana Rashid, Yu‐An Chen, Yu-An Chen +10 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Computer Science · #AI in cancer detection #Cancer Genomics and Diagnostics #Cell Image Analysis Techniques
26. From word models to executable models of signaling networks using automated assembly
    2017/11/01 by Benjamin M. Gyori, John A. Bachman, Kartik Subramanian +3 · 1 citation
    Computer Science · Medicine · Neuroscience · #Cholinesterase and Neurodegenerative Diseases #Computational Drug Discovery Methods #Computer science #Library science #Medical education #Medical school #Medicine #Neuroscience and Neural Engineering
27. 3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators
    2021/06/07 by Malia McAvoy, Ai‐Tram N. Bui, Christopher L. Hansen +19 · 1 citation
    Dentistry · Engineering · Medicine · #2019-20 coronavirus outbreak #3d printed #Computer science #Coronavirus disease 2019 (COVID-19) #Dental Research and COVID-19 #Engineering #Infection Control and Ventilation #Infectious disease (medical specialty) #Internal medicine #Manufacturing engineering #Materials science #Medicine #Respirator #Reuse #SARS-CoV-2 detection and testing #Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) #Virology #Waste management
28. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    2001/01/01 by Loren S. Michel, Vasco Liberal, Anupam Chatterjee +9 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · #Anaphase #Biology #Cancer #Cancer research #Cancer-related Molecular Pathways #Cell #Cell biology #Cell cycle #Cell cycle checkpoint #Cell division #Chromosome #Chromosome instability #Chromosome segregation #G2-M DNA damage checkpoint #Genetics #Genomics and Chromatin Dynamics #Mad2 #Metaphase #Microtubule and mitosis dynamics #Mitosis #Mitotic exit #Spindle apparatus #Spindle checkpoint
29. Measuring and Modeling Apoptosis in Single Cells
    2011/03/01 by Sabrina L. Spencer, Sabrina L. Spencer, Peter K. Sorger +1 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Computer Science · #Cell death mechanisms and regulation #Computational Drug Discovery Methods #Gene Regulatory Network Analysis
30. Evolution of delayed resistance to immunotherapy in a melanoma responder
    2021/05/03 by David Liu, Jia‐Ren Lin, Jia-Ren Lin +43 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Cancer research #Ecology #Immune system #Immunology #Immunotherapy #Immunotherapy and Immune Responses #Medicine #Melanoma #Resistance (ecology) #T-cell and B-cell Immunology #vaccines and immunoinformatics approaches
31. Heat shock factor is regulated differently in yeast and HeLa cells
    1987/09/01 by Peter K. Sorger, Michael Lewis, Michael J. Lewis +2 · 2 citations
    Biochemistry, Genetics and Molecular Biology · Chemistry · #Binding site #Biochemistry #Biology #Cell biology #DNA #Gene #Genetics, Aging, and Longevity in Model Organisms #HSF1 #HSPA14 #HSPA4 #HeLa #Heat shock #Heat shock factor #Heat shock protein #Heat shock proteins research #Hsp70 #In vitro #Molecular biology #Transcription (linguistics) #Transcription factor #Yeast #thermodynamics and calorimetric analyses
32. Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
    2021/08/28 by Caitlin E. Mills, Kartik Subramanian, Marc Hafner +9 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Medicine · #Advanced Fluorescence Microscopy Techniques #Biochemistry #Bioinformatics #Biology #Biomedical engineering #Cell #Cell Image Analysis Techniques #Chemistry #Computational biology #Computer science #Drop (telecommunication) #Engineering #Flow cytometry #High-content screening #High-throughput screening #Limiting #Materials science #Medicine #Molecular biology #Multiplexing #Nanotechnology #Single-cell and spatial transcriptomics
33. Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms
    2021/10/01 by Mohammed AlQuraishi, Peter K. Sorger · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Gene Regulatory Network Analysis #Protein Structure and Dynamics
34. Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
    2017/03/20 by Floris Foijer, Lee A. Albacker, Björn Bakker +12 · 1 citation
    Medicine · Biochemistry, Genetics and Molecular Biology · #Cancer-related Molecular Pathways #Genomic variations and chromosomal abnormalities #Cancer Genomics and Diagnostics
35. Regulatory and Safety Considerations in Deploying a Locally Fabricated, Reusable Face Shield in a Hospital Responding to the COVID-19 Pandemic
    2020/06/19 by Arash Mostaghimi, Marc‐Joseph Antonini, Deborah Plana +13 · 1 citation
    Medicine · Health Professions · #Infection Control and Ventilation #Disaster Response and Management #Infection Control in Healthcare
36. Copanlisib in combination with nivolumab formicrosatellite stable colorectal cancer: a phase 1/2 trial
    2026/07/23 by Eric S. Christenson, Jeremiah A. Wala, Rose Parkinson +24 · 1 voice
    Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer Immunotherapy and Biomarkers #Colorectal Cancer Treatments and Studies #PI3K/AKT/mTOR signaling in cancer