Metrics other than potency reveal systematic variation in responses to cancer drugs

2013/09/08 by Mohammad Fallahi-Sichani, Mohammad Fallahi‐Sichani, Saman Honarnejad +6 · 3 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Cancer therapeutics and mechanisms #Computational Drug Discovery Methods #Receptor Mechanisms and Signaling

paper · doi:10.1038/nchembio.1337

crossref issued 2013/09/08 · crossref published 2013/09/08 · crossref published-online 2013/09/08 · openalex publication_date 2013/09/08 · crossref created 2013/09/08 · crossref published-print 2013/11/01 · crossref deposited 2024/05/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/02

Citations

• Cyclin is degraded by the ubiquitin pathway
• Understanding the Dose-Effect Relationship
• Systematic identification of genomic markers of drug sensitivity in cancer cells
• Predicting new molecular targets for known drugs

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• Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
• Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
• Peter Karl Sorger [wikipedia]