Predicting new molecular targets for known drugs

2009/11/01 by Michael J. Keiser, Vincent Setola, John J. Irwin +17 · 11 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Chemical Synthesis and Analysis #Computational Drug Discovery Methods #Receptor Mechanisms and Signaling

paper · doi:10.1038/nature08506

crossref issued 2009/11/01 · crossref published 2009/11/01 · crossref published-online 2009/11/01 · crossref published-print 2009/11/01 · openalex publication_date 2009/11/01 · crossref created 2009/11/01 · crossref deposited 2025/02/12 · openalex created_date 2025/10/10 · crossref indexed 2026/08/02 · openalex updated_date 2026/08/02

Citations

• Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
• Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex
• Basic local alignment search tool
• When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor
• The Expanded Biology of Serotonin
• Drug Target Identification Using Side-Effect Similarity

Cited by

• Synthesis and characterization of high‐purity N,N‐dimethyltryptamine hemifumarate for human clinical trials
• Characterization of the synthesis of N,N‐dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry
• Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
• Neuropharmacology of N,N-dimethyltryptamine
• A survey of yeast genomic assays for drug and target discovery
• The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor
• DREADDs for Neuroscientists
• Metrics other than potency reveal systematic variation in responses to cancer drugs
• Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs
• Genetics and Pharmacogenetics of Aminergic Transmitter Pathways in Functional Gastrointestinal Disorders
• Dimethyltryptamine [wikipedia]