When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor

2009/03/10 by Tsung‐Ping Su, Teruo Hayashi, D. Bruce Vaupel · 6 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Pharmacological Receptor Mechanisms and Effects #Receptor Mechanisms and Signaling #Tryptophan and brain disorders

paper · doi:10.1126/scisignal.261pe12

openalex publication_date 2009/03/10 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/31

Abstract

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine-associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.

Citations

• Dose-Response Study of N,N-Dimethyltryptamine in Humans
• Dose-Response Study of N,N-Dimethyltryptamine in Humans
• Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics
• Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor

Cited by

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• Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter
• Predicting new molecular targets for known drugs
• LC/MS/MS analysis of the endogenous dimethyltryptamine hallucinogens, their precursors, and major metabolites in rat pineal gland microdialysate
• Neuropharmacology of N,N-dimethyltryptamine
• Estudio morfológico y morfométrico de la biopsia transbronquial en trasplante pulmonar y su evolución clínico-patológica
• Dimethyltryptamine [wikipedia]