Systematic identification of genomic markers of drug sensitivity in cancer cells

2012/03/01 by Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn +58 · 18 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #PARP inhibition in cancer therapy #Cancer Genomics and Diagnostics #RNA modifications and cancer

paper · doi:10.1038/nature11005

Cited by

• Genetic and transcriptional evolution alters cancer cell line drug response
• Translational Horizons in the Tumor Microenvironment: Harnessing Breakthroughs and Targeting Cures
• The Hallmarks of Predictive Oncology
• Lassoed Forests: Random Forests with Adaptive Lasso Post-selection
• Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
• Mapping drug mechanisms with ProteomicsDB: unified omics and cell sensitivity data at scale
• Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells
• The complex landscape of luminal breast cancer
• The present and future of the Cancer Dependency Map
• Evaluation of statistical approaches for association testing in noisy drug screening data
• Discovering Association Rules in High-Dimensional Small Tabular Data
• MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach
• Systems biology successes and areas for opportunity in prostate cancer
• The Cancer Genome Atlas Pan-Cancer analysis project
• Conditional Independence Testing using Generative Adversarial Networks
• Increasing trustworthiness of machine learning-based drug sensitivity prediction with a multivariate random forest approach
• Beyond the traditional dish: Advanced 3D ex vivo culture platforms for tumor modelling
• Genetic Features for Drug Responses in Cancer -- Investigating an Ensemble-Feature-Selection Approach