- Sex and age shape mitochondrial function in a long-lived seabird
2026/03/27 by Matteo Beccardi, Justine Bertram, Sandra Bouwhuis +4 · 2 voices · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Ageing #Avian ecology and behavior #Bioenergetics #Ectotherm #Function (biology) #Mitochondrial DNA #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #Physiological and biochemical adaptations
- Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson’s Disease
2026/02/09 by Erna Sól Sigmarsdóttir, Vasileios Voutsinos, Kristoffer E. Johansson +4 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Disease #Gene #Genetic variants #Key (lock) #Mitophagy #Mutation #Parkin #Parkinson's Disease Mechanisms and Treatments #Pathogenicity #Ubiquitin and proteasome pathways
- Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF
2024/09/27 by Akira Yoshii, Timothy S. McMillen, Yajun Wang +9 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Autophagy #Beta oxidation #Biochemistry #Cardiac Fibrosis and Remodeling #Cardiology #Cardiovascular Function and Risk Factors #Chemistry #Ejection fraction #Endocrinology #Energy metabolism #Heart failure #Heart failure with preserved ejection fraction #Internal medicine #Medicine #Metabolism #Mitochondrial Function and Pathology #Mitochondrial ROS #Mitochondrion #Mitophagy #Oxidative stress #Phosphocreatine
- Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat
2024/05/31 by Yayu Chen, Gen Wei, Xiaojin Feng +2 · 6 citations
Chemistry · Medicine · Neuroscience · #Anesthesia and Neurotoxicity Research #Apoptosis #Autophagy #Biochemistry #Biology #Cell biology #Chemistry #Cognition #Downregulation and upregulation #Hippocampal formation #Hippocampus #Intensive Care Unit Cognitive Disorders #Medicine #Mitochondrial fission #Mitochondrion #Mitophagy #Neuroscience #PINK1 #Pharmacology #Postoperative cognitive dysfunction #Programmed cell death #Pyroptosis
- Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf
2024/04/05 by Fang Chen · 10 citations
Chemistry · Medicine · #Adipose Tissue and Metabolism #Antioxidant #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cancer research #Cell biology #Chemistry #FIS1 #Gene knockdown #Internal medicine #MFN1 #MFN2 #Medicine #Mitochondrial DNA #Mitochondrion #Mitophagy #PINK1 #Parkin #Pharmacology #Quercetin #Sirtuins and Resveratrol in Medicine #mitochondrial fusion
- Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6
2024/01/29 by Tsz Chui Sophia Leung, Eviatar Fields, Namrata Rana +5 · 11 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Amyotrophic Lateral Sclerosis Research #Autophagy #Biology #Disease #Gene #Genetic Neurodegenerative Diseases #Genetics #Medicine #Mitochondrial DNA #Mitochondrial Encephalomyopathies #Mitochondrial Function and Pathology #Mitochondrial disease #Mitochondrial myopathy #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's disease #Pathology
- Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1
2023/01/10 by Feliciano Monterrubio-Ledezma, Fernando Navarro‐García, Lourdes Massieu +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Nursing · #Nuclear Structure and Function #Mitochondrial Function and Pathology #Trace Elements in Health #Progeria #Mitochondrion #Cell biology #Mitochondrial biogenesis #Biology #Mitophagy #Biogenesis #Premature aging #Lamin #Autophagy #Genetics #Gene #Nucleus #Apoptosis
- PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
2022/12/08 by Yun Li, Hengxing Chen, Xuan Xie +14 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Bacteria #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cancer, Hypoxia, and Metabolism #Cell biology #Chemistry #Homeostasis #Mitophagy #Multidrug tolerance #Oxidative phosphorylation #PI3K/AKT/mTOR signaling in cancer #PINK1 #Phosphorylation #Redox
- Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway
2022/07/31 by Weike Liu, Huajing Song, Jing Xu +7 · 13 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Caveolin-1 and cellular processes #Cell biology #Chemistry #Endocrinology #Endothelial dysfunction #Kruppel-like factors research #Mitochondrion #Mitophagy #Oxidative stress #PINK1
- Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis
2022/04/14 by Qiaoyun Bai, Zhiguang Wang, Yihua Piao +9 · 12 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Cancer research #Chemistry #Genomics, phytochemicals, and oxidative stress #Immunology #Inflammation #Internal medicine #Medicine #Mitophagy #Oxidative stress #Parkin #Pharmacology #Reactive oxygen species #Sesame and Sesamin Research #Sesamin #Superoxide dismutase #Tumor necrosis factor alpha
- PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy
2018/06/23 by Yiyang Wang, Jieliang Shen, Yanyang Chen +5 · 25 citations
Medicine · #Apoptosis #Autophagy #Biochemistry #Biology #Cell biology #Internal medicine #Medicine #Mitochondrion #Mitophagy #Oxidative stress #PI3K/AKT/mTOR pathway #PINK1 #PTEN #Parkin #Senescence #Signal transduction #Spinal Cord Injury Research #Spinal Hematomas and Complications #Spine and Intervertebral Disc Pathology #Tensin
- Weaning disrupts intestinal antioxidant status, impairs intestinal barrier and mitochondrial function, and triggers mitophagy in piglets1
2018/03/01 by Shu Cao, S T Cao, C C Wang +7 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Andrology #Antioxidant #Apoptosis #Autophagy #Biochemistry #Biology #Chemistry #Diet and metabolism studies #Endocrinology #Glutathione peroxidase #Glutathione reductase #Gut microbiota and health #Internal medicine #Jejunum #Malondialdehyde #Medicine #Mitophagy #Nutritional Studies and Diet #Oxidative stress #Superoxide dismutase #Weaning
- Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis
2017/07/01 by Dario C Altieri, Dario C. Altieri · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ATP Synthase and ATPases Research #Apoptosis #Autophagy #Biology #Cancer #Cancer, Hypoxia, and Metabolism #Cell #Cell biology #Disease #Druggability #Gene #Genetics #Medicine #Metastasis #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #Organelle #Pathology #Reprogramming
- Mitochondrial biology, targets, and drug delivery
2015/04/05 by Lara Milane, Malav Trivedi, Amit Singh +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #ATP Synthase and ATPases Research #Apoptosis #Autophagy #Biology #Cell biology #Cellular pathology #DNAJA3 #Genetics #Heteroplasmy #Medicine #Metabolism and Genetic Disorders #Mitochondrial DNA #Mitochondrial Function and Pathology #Mitochondrial disease #Mitochondrial fission #Mitochondrion #Mitophagy #PINK1 #Pathology #mitochondrial fusion
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014/04/21 by Lesley A. Kane, Michael Lazarou, Adam I. Fogel +5 · 44 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #Molecular biology #PINK1 #Parkin #Phosphorylation #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase
- The role of mitochondria in the oncogenic signal transduction
2014/01/04 by Christian Frezza · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Autophagy #Biology #Cancer, Hypoxia, and Metabolism #Cancer-related Molecular Pathways #Cell #Cell biology #Genetics #Intracellular #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #Organelle #Programmed cell death #Signal transduction
- Mitophagy: mechanisms, pathophysiological roles, and analysis
2012/07/01 by Wen-Xing Ding, Xiao-Ming Yin · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #Mitochondrial Function and Pathology #Heme Oxygenase-1 and Carbon Monoxide #Mitophagy #Autophagy #Mitochondrion #Parkin #Cell biology #Programmed cell death #Biology #PINK1 #Apoptosis #Medicine #Biochemistry #Parkinson's disease
- Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
2010/05/10 by Joo-Yong Lee, Joo‐Yong Lee, Yoshito Nagano +4 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Aggresome #Autophagy #Autophagy in Disease and Therapy #Biology #Cell biology #Disease #Gene #Genetics #Histone Deacetylase Inhibitors Research #Medicine #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Parkinsonism #Protein aggregation #Ubiquitin #Ubiquitin ligase
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008/11/24 by Derek Narendra, Derek P. Narendra, Atsushi Tanaka +3 · 75 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biology #Cell biology #Disease #Drosophila melanogaster #Gene #Genetics #Internal medicine #Medicine #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Ubiquitin #Ubiquitin ligase
- Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
2008/01/17 by Gilad Twig, Alvaro Elorza, Álvaro A. Elorza +22 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Endoplasmic Reticulum Stress and Disease #FIS1 #Gene #Lipid bilayer fusion #MFN2 #Membrane #Mitochondrial DNA #Mitochondrial Function and Pathology #Mitochondrial fission #Mitochondrion #Mitophagy #mitochondrial fusion