- Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson’s Disease
2026/02/09 by Erna Sól Sigmarsdóttir, Vasileios Voutsinos, Kristoffer E. Johansson +4 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Disease #Gene #Genetic variants #Key (lock) #Mitophagy #Mutation #Parkin #Parkinson's Disease Mechanisms and Treatments #Pathogenicity #Ubiquitin and proteasome pathways
- Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf
2024/04/05 by Fang Chen · 10 citations
Chemistry · Medicine · #Adipose Tissue and Metabolism #Antioxidant #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cancer research #Cell biology #Chemistry #FIS1 #Gene knockdown #Internal medicine #MFN1 #MFN2 #Medicine #Mitochondrial DNA #Mitochondrion #Mitophagy #PINK1 #Parkin #Pharmacology #Quercetin #Sirtuins and Resveratrol in Medicine #mitochondrial fusion
- Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6
2024/01/29 by Tsz Chui Sophia Leung, Eviatar Fields, Namrata Rana +5 · 11 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Amyotrophic Lateral Sclerosis Research #Autophagy #Biology #Disease #Gene #Genetic Neurodegenerative Diseases #Genetics #Medicine #Mitochondrial DNA #Mitochondrial Encephalomyopathies #Mitochondrial Function and Pathology #Mitochondrial disease #Mitochondrial myopathy #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's disease #Pathology
- Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis
2022/04/14 by Qiaoyun Bai, Zhiguang Wang, Yihua Piao +9 · 12 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Cancer research #Chemistry #Genomics, phytochemicals, and oxidative stress #Immunology #Inflammation #Internal medicine #Medicine #Mitophagy #Oxidative stress #Parkin #Pharmacology #Reactive oxygen species #Sesame and Sesamin Research #Sesamin #Superoxide dismutase #Tumor necrosis factor alpha
- PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy
2018/06/23 by Yiyang Wang, Jieliang Shen, Yanyang Chen +5 · 25 citations
Medicine · #Apoptosis #Autophagy #Biochemistry #Biology #Cell biology #Internal medicine #Medicine #Mitochondrion #Mitophagy #Oxidative stress #PI3K/AKT/mTOR pathway #PINK1 #PTEN #Parkin #Senescence #Signal transduction #Spinal Cord Injury Research #Spinal Hematomas and Complications #Spine and Intervertebral Disc Pathology #Tensin
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014/04/21 by Lesley A. Kane, Michael Lazarou, Adam I. Fogel +5 · 44 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #Molecular biology #PINK1 #Parkin #Phosphorylation #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase
- Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
2010/05/10 by Joo-Yong Lee, Joo‐Yong Lee, Yoshito Nagano +4 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Aggresome #Autophagy #Autophagy in Disease and Therapy #Biology #Cell biology #Disease #Gene #Genetics #Histone Deacetylase Inhibitors Research #Medicine #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Parkinsonism #Protein aggregation #Ubiquitin #Ubiquitin ligase
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008/11/24 by Derek Narendra, Derek P. Narendra, Atsushi Tanaka +3 · 74 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biology #Cell biology #Disease #Drosophila melanogaster #Gene #Genetics #Internal medicine #Medicine #Mitochondrial Function and Pathology #Mitochondrion #Mitophagy #PINK1 #Parkin #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Ubiquitin #Ubiquitin ligase