PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy

2018/06/23 by Yiyang Wang, Jieliang Shen, Yanyang Chen +5 · 25 citations
Medicine · #Spine and Intervertebral Disc Pathology #Spinal Cord Injury Research #Spinal Hematomas and Complications

paper · doi:10.1016/j.bbrc.2018.06.031

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• A Polysaccharide Purified from Morchella conica Pers. Prevents Oxidative Stress Induced by H₂O₂ in Human Embryonic Kidney (HEK) 293T Cells. [europepmc]
• Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway. [europepmc]
• Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells. [europepmc]
• SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. [europepmc]
• Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries. [europepmc]
• LDHA-Mediated Glycolytic Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration. [europepmc]
• Deficiency of MIF Accentuates Overloaded Compression-Induced Nucleus Pulposus Cell Oxidative Damage via Depressing Mitophagy. [europepmc]
• Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implications for the Pathogenesis and Potential Therapeutics. [europepmc]
• CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro. [europepmc]
• Hub Genes and Key Pathways of Intervertebral Disc Degeneration: Bioinformatics Analysis and Validation. [europepmc]
• Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review). [europepmc]
• Mitochondrial Dysfunction in Oxidative Stress-Mediated Intervertebral Disc Degeneration. [europepmc]
• Mitophagy-A New Target of Bone Disease. [europepmc]
• The role of ageing and oxidative stress in intervertebral disc degeneration. [europepmc]
• Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation. [europepmc]
• PINK1/Parkin-mediated mitophagy enhances the survival of Staphylococcus aureus in bovine macrophages. [europepmc]
• The role of autophagy in bone metabolism and clinical significance. [europepmc]
• Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities. [europepmc]
• Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration. [europepmc]
• The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration. [europepmc]
• Role of Autophagy and Pyroptosis in Intervertebral Disc Degeneration. [europepmc]
• Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases. [europepmc]
• Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies. [europepmc]
• PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging. [europepmc]
• Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi-Axial Perspective of Mechanical, Immune, and Metabolic Pathways. [europepmc]