- COVID-19 Vaccines: Adenoviral Vectors
2021/10/05 by Catherine Jacob-Dolan, Dan H. Barouch · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #2019-20 coronavirus outbreak #Biology #Coronavirus #Coronavirus disease 2019 (COVID-19) #Disease #Gene #Infectious disease (medical specialty) #Medicine #Outbreak #Pandemic #SARS-CoV-2 and COVID-19 Research #Serotype #Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) #Viral Infections and Outbreaks Research #Viral vector #Virology #Virus-based gene therapy research
- Chitosan for gene delivery: Methods for improvement and applications
2019/03/21 by Di Chuan, Tao Jin, Rangrang Fan +2 · 26 citations
Biochemistry, Genetics and Molecular Biology · #Advanced biosensing and bioanalysis techniques #Biochemistry #Biology #Chitosan #Computational biology #Delivery system #Gene #Gene delivery #Genetic enhancement #Genetics #Immune system #Immunogenicity #Immunology #Materials science #Nanotechnology #Pharmacology #RNA Interference and Gene Delivery #Recombinant DNA #Vector (molecular biology) #Viral vector #Virus-based gene therapy research
- Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
2017/07/01 by Michael Naso, Brian Tomkowicz, William L. Perry +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Adeno-associated virus #Bioinformatics #Biology #Computational biology #Gene #Gene delivery #Genetic enhancement #Genetics #Medicine #RNA Interference and Gene Delivery #Recombinant DNA #Vector (molecular biology) #Vectors in gene therapy #Viral Infections and Immunology Research #Viral vector #Virology #Virus #Virus-based gene therapy research
- Gene Therapy in a Patient with Sickle Cell Disease
2017/03/01 by Jean-Antoine Ribeil, Jean‐Antoine Ribeil, Salima Hacein-Bey-Abina +33 · 30 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Biology #Busulfan #Disease #Gene #Genetic enhancement #Genetics #Globin #Hematopoietic stem cell transplantation #Hemoglobin #Hemoglobinopathies and Related Disorders #Hemoglobinopathy #Immunology #Internal medicine #Medicine #Missense mutation #Mutation #Parvovirus B19 Infection Studies #Recombinant DNA #Sickle cell anemia #Viral vector #Virus-based gene therapy research
- Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction
2017/01/12 by Pierluigi Lesizza, Giulia Prosdocimo, Valentina Martinelli +3 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Biotechnology #Cardiac Fibrosis and Remodeling #Cardiac function curve #Cardiology #Cardioprotection #Cell biology #Cell culture #Congenital heart defects research #Heart failure #In vivo #Intracardiac injection #Medicine #MicroRNA in disease regulation #Myocardial infarction #Pharmacology #Recombinant DNA #Regeneration (biology) #Systemic administration #Transfection #Viral vector #microRNA
- Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis
2016/11/16 by Eric W F W Alton, Eric W.F.W. Alton, Jeffery M Beekman +59 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Biology #Cystic fibrosis #Cystic fibrosis transmembrane conductance regulator #Energy Harvesting in Wireless Networks #Gene #Genetic enhancement #Genetics #Immunology #Internal medicine #Medicine #Neuraminidase inhibitor #Pathology #RNA Interference and Gene Delivery #Transduction (biophysics) #Vector (molecular biology) #Vectors in gene therapy #Viral vector #Virology #Virus-based gene therapy research
- Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?
2012/02/08 by Harald Mikkers, Karin Pike-Overzet, Karin Pike‐Overzet +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #CRISPR and Genetic Engineering #Computational biology #Embryonic stem cell #Gene #Genetic enhancement #Genetics #Genome #Haematopoiesis #Hematopoietic stem cell #Human immunodeficiency virus (HIV) #Immunology #Induced pluripotent stem cell #Insertional mutagenesis #Lentivirus #Medicine #Mutagenesis #Mutation #Pluripotent Stem Cells Research #Severe combined immunodeficiency #Stem cell #Viral disease #Viral vector #Virus-based gene therapy research
- We still have a Long Way to go to Effectively Deliver Genes!
2012/01/01 by Daniele Pezzoli, Roberto Chiesa, Luigi De Nardo +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced biosensing and bioanalysis techniques #Bioinformatics #Biology #Computational biology #Computer science #Gene #Gene delivery #Gene silencing #Genetic enhancement #Genetics #Materials science #Medicine #Nanotechnology #RNA Interference and Gene Delivery #Risk analysis (engineering) #Vector (molecular biology) #Viral vector #Virus-based gene therapy research
- Viral vectors as vaccine platforms: deployment in sight
2011/04/22 by Christine S Rollier, Christine S. Rollier, Arturo Reyes-Sandoval +6 · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Encephalitis #Genetics #HIV Research and Treatment #Immune system #Immunity #Immunology #Licensure #Medicine #Recombinant DNA #Vector (molecular biology) #Viral encephalitis #Viral replication #Viral vector #Virology #Virology and Viral Diseases #Virus #Virus-based gene therapy research
- Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor
2010/10/06 by Yangbing Zhao, Edmund Moon, Edmund K. Moon +12 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adoptive cell transfer #Antigen #Biology #CAR-T cell therapy research #Cancer immunotherapy #Cancer research #Chimeric antigen receptor #Electroporation #Gene #Genetic enhancement #Immune system #Immunology #Immunotherapy #Recombinant DNA #T cell #Viral Infectious Diseases and Gene Expression in Insects #Viral vector #Virus-based gene therapy research
- Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
2010/09/01 by Marina Cavazzana-Calvo, Marina Cavazzana, Emmanuel Payen +47 · 9 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Allele #Biology #Blood transfusion #Gene #Genetic enhancement #Genetics #Haematopoiesis #Hemoglobinopathies and Related Disorders #Immunology #RNA Interference and Gene Delivery #Stem cell #Thalassemia #Transfusion therapy #Viral vector #Virus-based gene therapy research
- The evolution of gene therapy in X-linked severe combined immunodeficiency
2009/05/01 by Tonya S. Rans, Ronald England, Ronald W. England · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adverse effect #Animal Genetics and Reproduction #Biology #Gene #Genetic enhancement #Genetics #Immune system #Immunodeficiency #Immunodeficiency and Autoimmune Disorders #Immunology #Internal medicine #Medicine #Oncology #Retrovirus #Severe combined immunodeficiency #Vector (molecular biology) #Viral vector #Virus #Virus-based gene therapy research
- Semliki Forest virus vectors for gene therapy
2003/08/01 by Kenneth Lundström · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Alphavirus #Biology #Capsid #Gene #Genetic enhancement #Genetics #Heterologous #Mosquito-borne diseases and control #Oncolytic virus #Plasmid #RNA #Recombinant DNA #Replicon #Retrovirus #Semliki Forest virus #Vectors in gene therapy #Viral Infections and Vectors #Viral vector #Virology #Virus #Virus-based gene therapy research
- Occurrence of leukaemia following gene therapy of X-linked SCID
2003/07/01 by Donald B. Kohn, Michel Sadelain, Joseph C. Glorioso · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #CAR-T cell therapy research #Cancer #Gene #Gene transfer #Genetic enhancement #Genetics #Immune system #Immunology #Internal medicine #Medicine #Oncology #RNA Interference and Gene Delivery #Recombinant DNA #Viral vector #Virus-based gene therapy research
- Immune response following intraocular delivery of recombinant viral vectors
2003/05/20 by Jean Bennett, J Bennett · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adeno-associated virus #Adenoviridae #Biology #Gene #Genetic enhancement #Genetics #Herpesvirus Infections and Treatments #Immune system #Immunology #Lentivirus #Recombinant DNA #Recombinant virus #Vector (molecular biology) #Viral disease #Viral vector #Virology #Virus #Virus-based gene therapy research #interferon and immune responses