1. Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
   2025/12/18 by Annika Oßwald, Annika Osswald, Esther Wortmann +34 · 1 voice · 5 citations
   Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Bacteria #Colorectal cancer #Drug Transport and Resistance Mechanisms #Gut bacteria #Gut flora #Gut microbiota and health #Gut microflora #Probiotics and Fermented Foods
2. The effects of the COVID-19 pandemic on neurobiological functioning in adolescents
   2025/08/12 by Justin P. Yuan, Lauren R. Borchers, Yoon Ji Lee +6 · 3 citations
   Medicine · Neuroscience · Psychology · #2019-20 coronavirus outbreak #Adverse effect #COVID-19 and Mental Health #Clinical psychology #Cognition #Coronavirus disease 2019 (COVID-19) #Developmental psychology #Disease #Internal medicine #Medicine #Neuroscience #Pandemic #Prefrontal cortex #Psychiatry #Psychology #Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) #Stress Responses and Cortisol #Tryptophan and brain disorders #Virology
3. The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model
   2025/05/10 by Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité · 8 citations
   Medicine · Neuroscience · #Adverse effect #Clinical trial #Drug #Drug development #Drug trial #Epilepsy #Epilepsy research and treatment #Internal medicine #Investigational Drugs #Medicine #Neuroscience and Neuropharmacology Research #Pathology #Pharmacological Effects and Toxicity Studies #Pharmacology #Phases of clinical research #Placebo #Psychiatry #Surrogate endpoint
4. Progression of coronary artery calcium density and major adverse cardiovascular events
   2024/09/06 by Qingchao Meng, Li Zhao, Na Zhao +4 · 6 citations
   Medicine · #Adverse effect #Calcium #Cardiac Imaging and Diagnostics #Cardiology #Cardiovascular Disease and Adiposity #Coronary Interventions and Diagnostics #Coronary artery calcium #Coronary artery disease #Internal medicine #Medicine
5. Drugs Targeting CD20 in Multiple Sclerosis: Pharmacology, Efficacy, Safety, and Tolerability
   2024/03/01 by Alise K. Carlson, Alise Carlson, Moein Amin +1 · 25 citations
   Immunology and Microbiology · Medicine · #Adverse effect #CAR-T cell therapy research #Clinical trial #Fingolimod #Immunology #Immunotherapy and Immune Responses #Intensive care medicine #Internal medicine #Lymphoma #Medicine #Monoclonal and Polyclonal Antibodies Research #Multiple sclerosis #Ocrelizumab #Ofatumumab #Oncology #Pharmacology #Rituximab #Teriflunomide #Tolerability
6. Tirzepatide: A Review in Type 2 Diabetes
   2024/02/01 by Nicole L. France, Yahiya Y. Syed · 25 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Diabetes Treatment and Management #Diabetes mellitus #Dulaglutide #Endocrinology #Exenatide #Incretin #Insulin #Internal medicine #Liraglutide #Medicine #Metabolism, Diabetes, and Cancer #Nausea #Obesity #Pharmacology and Obesity Treatment #Semaglutide #Type 2 Diabetes Mellitus #Type 2 diabetes #Weight loss
7. Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS‐CVOT design and baseline characteristics
   2023/09/25 by Stephen J. Nicholls, Deepak L Bhatt, Deepak L. Bhatt +29 · 33 citations
   Medicine · #Adverse effect #Atherosclerotic cardiovascular disease #Baseline (sea) #Cardiology #Diabetes Treatment and Management #Diabetes mellitus #Diabetes, Cardiovascular Risks, and Lipoproteins #Disease #Dulaglutide #Endocrinology #Exenatide #Hyperglycemia and glycemic control in critically ill and hospitalized patients #Internal medicine #Medicine #Type 2 diabetes
8. Therapeutic efficacy of intravenous lidocaine infusion compared with thoracic epidural analgesia in major abdominal surgery: a noninferiority randomised clinical trial
   2023/09/26 by Fabián David Casas-Arroyave, Fabian D. Casas-Arroyave, Susana C. Osorno-Upegui +2 · 15 citations
   Medicine · #Abdominal surgery #Adverse effect #Analgesic #Anesthesia #Anesthesia and Pain Management #Bupivacaine #Clinical trial #Confidence interval #Internal medicine #Lidocaine #Medicine #Morphine #Pain Management and Opioid Use #Pediatric Pain Management Techniques #Randomized controlled trial #Surgery
9. Telepsychiatry versus face-to-face treatment: systematic review and meta-analysis of randomised controlled trials
   2023/09/01 by Katsuhiko Hagi, Shunya Kurokawa, Akihiro Takamiya +6 · 19 citations
   Medicine · Psychology · #Adverse effect #COVID-19 and Mental Health #Digital Mental Health Interventions #Discontinuation #Face-to-face #Health care #Internal medicine #Medicine #Meta-analysis #Psychiatry #Telemedicine #Telemedicine and Telehealth Implementation #Telepsychiatry #Tolerability
10. Preoperative Risk Factors for Adverse Events in Adults Undergoing Bowel Resection for Inflammatory Bowel Disease: 15-Year Assessment of the American College of Surgeons National Surgical Quality Improvement Program
    2023/07/06 by Cristina Fernández, Cristina Fernandez, Zoran Gajic +13 · 11 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Appendicitis Diagnosis and Management #Colectomy #Confidence interval #Disease #Enhanced Recovery After Surgery #Inflammatory Bowel Disease #Inflammatory bowel disease #Internal medicine #Medicine #Odds ratio #Quality of life (healthcare) #Surgery #Ulcerative colitis #Young adult
11. Prolonged Symptoms after COVID-19 in Japan: A Nationwide Survey of the Symptoms and Their Impact on Patients’ Quality of Life
    2023/05/25 by Hitoshi Honda, Akane Takamatsu, Toshiki Miwa +4 · 8 citations
    Medicine · Psychology · #Adverse effect #COVID-19 and Mental Health #Chronic Obstructive Pulmonary Disease (COPD) Research #Comorbidity #Confidence interval #Confounding #Coronavirus disease 2019 (COVID-19) #Disease #Dysgeusia #Internal medicine #Long-Term Effects of COVID-19 #Medicine #Odds ratio #Physical therapy #Quality of life (healthcare)
12. Antipsychotics and obsessive–compulsive disorder/obsessive–compulsive symptoms: A pharmacovigilance study of the FDA adverse event reporting system
    2023/05/17 by Bradley G. Burk, Tilyn DiGiacomo, Shea Polancich +3 · 10 citations
    Medicine · Pharmacology, Toxicology and Pharmaceutics · Psychology · #Adverse Event Reporting System #Adverse effect #Antipsychotic #Aripiprazole #Atypical antipsychotic #Clozapine #Internal medicine #Medicine #Obsessive-Compulsive Spectrum Disorders #Pharmacovigilance #Pharmacovigilance and Adverse Drug Reactions #Psychiatry #Quetiapine #Risperidone #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment
13. Side-effects and adverse events of a shoulder- and back-support exoskeleton in workers: A systematic review
    2023/05/02 by S.E. Kranenborg, C. Greve, M.F. Reneman +3 · 16 citations
    Engineering · Medicine · #Adverse effect #Computer science #Exoskeleton #Internal medicine #Medicine #Pain Management and Treatment #Physical medicine and rehabilitation #Physical therapy #Prosthetics and Rehabilitation Robotics #Side effect (computer science) #Stroke Rehabilitation and Recovery #Usability
14. Real-life safety profile of mRNA vaccines for COVID-19: An analysis of VAERS database
    2023/03/28 by Greta Santi Laurini, Nicola Montanaro, Massimiliano Broccoli +2 · 15 citations
    Agricultural and Biological Sciences · Immunology and Microbiology · Medicine · #Adverse Event Reporting System #Adverse effect #Animal Virus Infections Studies #Chills #Confidence interval #Emergency medicine #Immunology #Immunotherapy and Immune Responses #Internal medicine #MedDRA #Medical emergency #Medicine #Odds ratio #Pediatrics #Pharmacovigilance #SARS-CoV-2 and COVID-19 Research #Vaccination
15. Safety of Janus Kinase Inhibitors in Inflammatory Bowel Diseases
    2023/03/01 by Paulina Núñez, Rodrigo Quera, Andres J. Yarur +1 · 28 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Cytokine #Cytokine Signaling Pathways and Interactions #Disease #Inflammatory Bowel Disease #Inflammatory bowel disease #Internal medicine #Janus kinase #Medicine #Pharmacology #Rheumatoid Arthritis Research and Therapies #Rheumatoid arthritis #Tofacitinib #Ulcerative colitis
16. Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
    2023/02/02 by Frank Wagner, John C Mansfield, John Mansfield +15 · 13 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adverse effect #Dermatology #Dermatology and Skin Diseases #Dosing #Erythema #Gastroenterology #Inflammatory Bowel Disease #Internal medicine #Medicine #Pathology #Pharmacodynamics #Pharmacokinetics #Pharmacology #Placebo #Psoriasis #Psoriasis: Treatment and Pathogenesis #Surgery #Tolerability #Ulcerative colitis
17. Bimekizumab efficacy and safety in patients with moderate-to-severe plaque psoriasis who switched from adalimumab, ustekinumab or secukinumab: results from phase III/IIIb trials
    2022/11/29 by Georgios Kokolakis, Richard B Warren, Richard B. Warren +16 · 9 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adalimumab #Adverse effect #Clinical trial #Dermatology #Dermatology Life Quality Index #Discontinuation #Disease #Inflammatory Bowel Disease #Internal medicine #Medicine #Psoriasis #Psoriasis Area and Severity Index #Psoriasis: Treatment and Pathogenesis #Psoriatic arthritis #Secukinumab #Spondyloarthritis Studies and Treatments #Ustekinumab
18. Integrated safety analysis of baricitinib in adults with severe alopecia areata from two randomized clinical trials
    2022/11/11 by Brett King, Arash Mostaghimi, Yutaka Shimomura +14 · 20 citations
    Medicine · #Acne and Rosacea Treatments and Effects #Adverse effect #Alopecia areata #Clinical trial #Dermatology #Discontinuation #Facial Rejuvenation and Surgery Techniques #Hair Growth and Disorders #Incidence (geometry) #Internal medicine #Medicine #Placebo #Surgery #Upper respiratory tract infection
19. The role of sodium-glucose co-transporter-2 inhibitors in frail older adults with or without type 2 diabetes mellitus
    2022/10/01 by Marc Evans, Angharad R. Morgan, Angharad R Morgan +4 · 17 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Clinical trial #Diabetes Treatment and Management #Diabetes mellitus #Disease #Drug #Drug class #Endocrinology #Intensive care medicine #Internal medicine #Medicine #Metabolism, Diabetes, and Cancer #Pharmacology #Population #Post-hoc analysis #Potassium and Related Disorders #Type 2 Diabetes Mellitus #Type 2 diabetes
20. Safety of tralokinumab in adult patients with moderate-to-severe atopic dermatitis: pooled analysis of five randomized, double-blind, placebo-controlled phase II and phase III trials
    2022/09/09 by Eric L. Simpson, Joseph F. Merola, Jonathan I. Silverberg +13 · 27 citations
    Medicine · #Adverse effect #Allergic Rhinitis and Sensitization #Asthma and respiratory diseases #Atopic dermatitis #Confidence interval #Dermatology and Skin Diseases #Gastroenterology #Immunology #Internal medicine #Medicine #Pathology #Placebo #Randomized controlled trial #Upper respiratory tract infection
21. Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial
    2022/08/12 by Hermine I. Brunner, Hermine I Brunner, Ivan Foeldvari +31 · 23 citations
    Medicine · #Adverse effect #Arthritis #Autoimmune and Inflammatory Disorders Research #Clinical endpoint #Clinical trial #Enthesitis #Internal medicine #Medicine #Ocular Diseases and Behçet’s Syndrome #Pathology #Placebo #Psoriatic arthritis #Rheumatology #Secukinumab #Spondyloarthritis Studies and Treatments
22. Action observation for upper limb rehabilitation after stroke
    2022/08/05 by Lorenna Raquel Dantas de Macêdo Borges, Aline Braga Galvão Silveira Fernandes, Jacilda Oliveira dos Passos +2 · 1 citation
    Psychology · Medicine · #Action Observation and Synchronization #Stroke Rehabilitation and Recovery #Sport Psychology and Performance #Physical medicine and rehabilitation #Stroke (engine) #Medicine #Rehabilitation #Randomized controlled trial #Activities of daily living #Physical therapy #MEDLINE #Adverse effect #Clinical trial #Upper limb #Internal medicine
23. Modulation of autophagy: a Phase II study of vorinostat plus hydroxychloroquine versus regorafenib in chemotherapy-refractory metastatic colorectal cancer (mCRC)
    2022/06/23 by Sukeshi Patel Arora, Laura Tenner, John Sarantopoulos +8 · 21 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Aflibercept #Autophagy in Disease and Therapy #Bevacizumab #Biology #Cancer #Chemotherapy #Clinical endpoint #Clinical trial #Colorectal Cancer Treatments and Studies #Colorectal cancer #Histone Deacetylase Inhibitors Research #Histone deacetylase #Hydroxychloroquine #Internal medicine #Medicine #Oncology #Regorafenib #Vorinostat
24. The role of pancreatoscopy in the diagnostic work-up of intraductal papillary mucinous neoplasms: a systematic review and meta-analysis
    2022/06/03 by David M. de Jong, Pauline M. C. Stassen, Bas Groot Koerkamp +13 · 10 citations
    Medicine · #Adverse Event Reporting System #Adverse effect #Cochrane Library #Endoscopic retrograde cholangiopancreatography #Gallbladder and Bile Duct Disorders #General surgery #Internal medicine #Intraductal papillary mucinous neoplasm #MEDLINE #Medicine #Meta-analysis #Pancreas #Pancreatic and Hepatic Oncology Research #Pancreatitis #Pancreatitis Pathology and Treatment #Radiology
25. Pacritinib: First Approval
    2022/05/01 by Yvette N. Lamb · 20 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Bone marrow #Chronic Myeloid Leukemia Treatments #Essential thrombocythemia #Internal medicine #Kruppel-like factors research #Medicine #Myelofibrosis #Myeloproliferative Neoplasms: Diagnosis and Treatment #Pharmacology #Polycythemia vera #Randomized controlled trial #Safety profile
26. Predictors of adverse events after endoscopic ultrasound-guided through-the-needle biopsy of pancreatic cysts: a recursive partitioning analysis
    2022/04/21 by Antonio Facciorusso, Bojan Kovacevic, Dennis Yang +28 · 25 citations
    Medicine · #Adverse effect #Biopsy #Colorectal Cancer Screening and Detection #Endoscopic ultrasound #Endoscopy #General surgery #Internal medicine #Medicine #Pancreatic and Hepatic Oncology Research #Pancreatitis Pathology and Treatment #Radiology
27. Recognition and management of clozapine adverse effects: A systematic review and qualitative synthesis
    2022/02/18 by Ronald J. Gurrera, Priya F. Gearin, Jonathan Love +6 · 11 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Blood disorders and treatments #Clozapine #Discontinuation #Intensive care medicine #Internal medicine #Medicine #Neutropenia #Parkinson's Disease and Spinal Disorders #Pediatrics #Pharmacology #Psychiatry #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment #Toxicity
28. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
    2022/01/16 by Craig R. Lee, Jasmine A. Luzum, Katrin Sangkuhl +14 · 26 citations
    Medicine · Pharmacology, Toxicology and Pharmaceutics · #Active metabolite #Adverse effect #Antiplatelet Therapy and Cardiovascular Diseases #CYP2C19 #Clopidogrel #Genotype #Guideline #Pharmacogenetics #Pharmacogenetics and Drug Metabolism #Platelet Disorders and Treatments #Prodrug
29. Efficacy of biological therapies and small molecules in moderate to severe ulcerative colitis: systematic review and network meta-analysis
    2021/12/22 by Nicholas Burr, Nicholas E Burr, David J Gracie +5 · 28 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Clinical trial #Confidence interval #Gastroenterology #Inflammatory Bowel Disease #Infliximab #Internal medicine #Medicine #Meta-analysis #Natural Compounds in Disease Treatment #Pathology #Placebo #Relative risk #Rheumatoid Arthritis Research and Therapies #Surgery #Tumor necrosis factor alpha #Ulcerative colitis
30. Follow-up Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel (Mesenchymal Stem Cell Treatment) in Patients With Perianal Fistulizing Crohn’s Disease: ADMIRE-CD Phase 3 Randomized Controlled Trial
    2021/12/10 by Damián Garcia-Olmo, Damián García‐Olmo, Inmaculada Gilaberte +8 · 26 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Adverse effect #Anorectal Disease Treatments and Outcomes #Autoimmune and Inflammatory Disorders #Clinical trial #Crohn's disease #Disease #Fistula #Inflammatory Bowel Disease #Internal medicine #Medicine #Mesenchymal stem cell #Pathology #Randomized controlled trial #Surgery

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