1. Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
   2025/10/09 by Daniel Domínguez Azorín, Dirk C. Hoffmann, Nils Hebach +27 · 2 voices
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Cancer #Cancer cell #Disease #Drug #Drug development #Glioblastoma #Glioma Diagnosis and Treatment #Identification (biology) #Microtubule and mitosis dynamics #Neurogenesis and neuroplasticity mechanisms #Protein kinase C
2. The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model
   2025/05/10 by Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité · 8 citations
   Medicine · Neuroscience · #Adverse effect #Clinical trial #Drug #Drug development #Drug trial #Epilepsy #Epilepsy research and treatment #Internal medicine #Investigational Drugs #Medicine #Neuroscience and Neuropharmacology Research #Pathology #Pharmacological Effects and Toxicity Studies #Pharmacology #Phases of clinical research #Placebo #Psychiatry #Surrogate endpoint
3. Novel clinical trial designs emerging from the molecular reclassification of cancer
   2025/01/22 by Mina Nikanjam, Shumei Kato, Teresa Allen +2 · 8 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Bioinformatics #Biology #Biomarker #Biomarker discovery #Cancer Genomics and Diagnostics #Clinical trial #Computational biology #Computer science #Disease #Drug #Drug development #Genome #Genomics #Internal medicine #Lung Cancer Treatments and Mutations #Medicine #Pathology #Personalization #Personalized medicine #Pharmacology #Precision medicine #Proteomics #Radiomics and Machine Learning in Medical Imaging
4. PMDA Perspective on Use of Real‐World Data and Real‐World Evidence as an External Control: Recent Examples and Considerations
   2025/01/03 by Junichi Asano, Hiromi Sugano, Hiroyuki Murakami +3 · 5 citations
   Economics, Econometrics and Finance · Engineering · Mathematics · Medicine · #Business #Clinical trial #Computer science #Control (management) #Data science #Drug #Drug approval #Drug development #Engineering #Health Systems, Economic Evaluations, Quality of Life #Management science #Medicine #Pharmaceutical Economics and Policy #Pharmacology #Real world data #Risk analysis (engineering) #Statistical Methods in Clinical Trials
5. Recent progress in Stevens–Johnson syndrome/toxic epidermal necrolysis: diagnostic criteria, pathogenesis and treatment
   2024/08/14 by Natsumi Hama, Shigeki Aoki, Chun-Bing Chen +42 · 13 citations
   Medicine · #Autoimmune Bullous Skin Diseases #Dermatology #Disease #Drug #Drug development #Drug-Induced Adverse Reactions #Immunology #Intensive care medicine #Medicine #Mucocutaneous zone #Pathology #Pharmacology #Toxic epidermal necrolysis #Urticaria and Related Conditions
6. Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy
   2023/11/27 by Freya R. Weth, Georgia B. Hoggarth, Anya F. Weth +5 · 29 citations
   Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · Medicine · #Bioinformatics #Biology #Cancer #Click Chemistry and Applications #Computational Drug Discovery Methods #Context (archaeology) #Drug #Drug development #Drug discovery #Drug repositioning #Medicine #Pharmacology #Protein Degradation and Inhibitors #Repurposing #Risk analysis (engineering)
7. Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis
   2023/10/26 by Francesco Bonella, Paolo Spagnolo, Chris Ryerson +1 · 29 citations
   Medicine · #Clinical endpoint #Clinical trial #Disease #Drug #Drug development #Eosinophilic Disorders and Syndromes #Idiopathic pulmonary fibrosis #Intensive care medicine #Internal medicine #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Lung #Medicine #Nintedanib #Pharmacology #Pirfenidone #Sarcoidosis and Beryllium Toxicity Research
8. Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification
   2023/09/20 by Jeffrey L. Cummings, Amanda M. Leisgang Osse, Jefferson W. Kinney · 27 citations
   Computer Science · Medicine · Neuroscience · #Alzheimer's disease #Alzheimer's disease research and treatments #Bioinformatics #Biology #Biomarker #Cholinesterase and Neurodegenerative Diseases #Clinical trial #Cognitive decline #Computational Drug Discovery Methods #Dementia #Disease #Drug #Drug development #Drug repositioning #Internal medicine #Medicine #Neurodegeneration #Neuroprotection #Neuroscience #Pharmacology
9. Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel therapeutics
   2023/08/18 by Jessica R Pickett, Yuao Wu, Lucía F. Zacchi +3 · 27 citations
   Immunology and Microbiology · Medicine · #Atherosclerosis and Cardiovascular Diseases #Biochemistry #Bioinformatics #Biology #Cancer research #Cell #Cell Adhesion Molecules Research #Cell adhesion #Cell adhesion molecule #Cell biology #Drug #Drug development #Drug discovery #Function (biology) #ICAM-1 #Immunology #Medicine #Phagocytosis and Immune Regulation #Pharmacology #VCAM-1
10. Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies
    2023/07/13 by Nora Jamaladdin, Romain Sigaud, Daniela Kocher +12 · 2 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer #Cancer therapeutics and mechanisms #Clinical pharmacology #Clinical trial #Drug #Drug development #Intensive care medicine #Internal medicine #Medicine #Neuroblastoma Research and Treatments #Oncology #Pediatric cancer #Pharmaceutical studies and practices #Pharmacokinetics #Pharmacology #Volume of distribution
11. Adagrasib: First Approval
    2023/02/01 by Sohita Dhillon · 26 citations
    Medicine · #Cancer #Cancer research #Cancer-related Molecular Pathways #Clinical trial #Colorectal Cancer Treatments and Studies #Colorectal cancer #Drug #Drug approval #Drug development #Internal medicine #KRAS #Lung Cancer Treatments and Mutations #Medicine #Oncology #Pharmacology
12. Pimitespib: First Approval
    2022/08/20 by Sheridan M. Hoy · 26 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer, Hypoxia, and Metabolism #Chemotherapy #Colorectal Cancer Treatments and Studies #Drug #Drug development #GiST #Heat shock protein #Heat shock proteins research #Hsp90 #Hsp90 inhibitor #Imatinib #Intensive care medicine #Internal medicine #Medicine #Oncology #Pharmacology #Pharmacotherapy #Stromal cell
13. Landscape Analysis of the Application of Artificial Intelligence and Machine Learning in Regulatory Submissions for Drug Development From 2016 to 2021
    2022/06/16 by Qi Liu, Ruihao Huang, Julie Hsieh +12 · 24 citations
    Computer Science · Engineering · Immunology and Microbiology · Mathematics · Medicine · #Artificial intelligence #Biosimilars and Bioanalytical Methods #Computational Drug Discovery Methods #Computer science #Drug #Drug development #Drug repositioning #Engineering #Food and drug administration #License #Machine learning #Medicine #Pharmacology #Regulatory science #Repurposing #Statistical Methods in Clinical Trials
14. Biomarker Qualification at the European Medicines Agency: A Review of Biomarker Qualification Procedures From 2008 to 2020
    2022/02/09 by Elisabeth Bakker, Natalie M. Hendrikse, Falk Ehmann +6 · 24 citations
    Economics, Econometrics and Finance · Immunology and Microbiology · Mathematics · Medicine · #Agency (philosophy) #Biology #Biomarker #Biomarker discovery #Biosimilars and Bioanalytical Methods #Context (archaeology) #Drug #Drug development #Health Systems, Economic Evaluations, Quality of Life #Medical physics #Medicine #Pharmacology #Statistical Methods in Clinical Trials
15. Expert Panel Review to Compare FDA and EMA Guidance on Drug Development and Endpoints in Nonalcoholic Steatohepatitis
    2021/11/22 by Rohit Loomba, Vlad Ratziu, Stephen A. Harrison +9 · 27 citations
    Medicine · #Diet, Metabolism, and Disease #Drug #Drug development #Fatty liver #Internal medicine #Liver Disease Diagnosis and Treatment #Liver Diseases and Immunity #Medicine #Nonalcoholic fatty liver disease #Nonalcoholic steatohepatitis #Pharmacology #Steatohepatitis
16. Evolving Acceptance and Use of RWE for Regulatory Decision Making on the Benefit/Risk Assessment of a Drug in Japan
    2021/09/16 by Kinue Nishioka, Tomomi Makimura, Akihiro Ishiguro +3 · 22 citations
    Economics, Econometrics and Finance · Mathematics · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Business #Computer science #Computer security #Drug #Drug approval #Drug development #Health Systems, Economic Evaluations, Quality of Life #Medicine #Pharmacology #Pharmacy and Medical Practices #Regulatory science #Risk analysis (engineering) #Risk assessment #Statistical Methods in Clinical Trials
17. Alternative strategies in cardiac preclinical research and new clinical trial formats
    2021/03/03 by Fabian Philipp Kreutzer, Anna Meinecke, K. E. Schmidt +3 · 17 citations
    Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #3D Printing in Biomedical Research #Bioinformatics #Biology #Biomedical Ethics and Regulation #Clinical trial #Computer science #Drug #Drug development #Drug discovery #Drug repositioning #Intensive care medicine #Medical physics #Medicine #Pathology #Pharmacology #Pluripotent Stem Cells Research #Repurposing #Risk analysis (engineering) #Translational research
18. Regulators, Pivotal Clinical Trials, and Drug Regulation in the Age of COVID-19
    2020/12/21 by Joel Lexchin, Janice Graham, Matthew Herder +2 · 10 citations
    Economics, Econometrics and Finance · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Agency (philosophy) #Clinical trial #Coronavirus disease 2019 (COVID-19) #Disease #Drug #Drug approval #Drug development #Economics #Flexibility (engineering) #Food and drug administration #Health Systems, Economic Evaluations, Quality of Life #Infectious disease (medical specialty) #Law #Medicine #Pathology #Pharmaceutical Economics and Policy #Pharmaceutical industry and healthcare #Pharmacology #Political science #Public administration #Public relations #Regulatory affairs #Regulatory agency #Regulatory science #Transparency (behavior)
19. Utilising Graph Machine Learning within Drug Discovery and Development
    2020/12/09 by Thomas Gaudelet, Ben Day, Gaudelet, Thomas +26 · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · Engineering · Medicine · #Artificial intelligence #Bioinformatics #Bioinformatics and Genomic Networks #Biology #Click Chemistry and Applications #Computational Drug Discovery Methods #Computer science #Context (archaeology) #Data science #Drug #Drug development #Drug discovery #Drug repositioning #Engineering #FOS: Biological sciences #FOS: Computer and information sciences #Graph #Identification (biology) #Machine Learning (cs.LG) #Machine learning #Medicine #Pharmacology #Pipeline (software) #Quantitative Methods (q-bio.QM) #Repurposing #Theoretical computer science #cs.LG #q-bio.QM
20. Treatment of muscle‐invasive and advanced bladder cancer in 2020
    2020/08/07 by Vaibhav G. Patel, William K. Oh, William Oh +1 · 27 citations
    Medicine · #Bioinformatics #Biology #Bladder and Urothelial Cancer Treatments #Bladder cancer #Cancer #Cancer Immunotherapy and Biomarkers #Cancer research #Drug #Drug development #Immunotherapy #Internal medicine #Medicine #Oncology #Pharmacology #Urinary and Genital Oncology Studies
21. Biomarkers in Pharmaceutical Research
    2015/09/26 by Xuemei Zhao, Vijay Modur, Leonidas N. Carayannopoulos +3 · 19 citations
    Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Bioinformatics #Biological Research and Disease Studies #Biology #Biomarker #Biomarker discovery #Clinical trial #Disease #Drug #Drug development #GDF15 and Related Biomarkers #Internal medicine #Medicine #Oncology #Pathology #Personalized medicine #Pharmaceutical sciences #Pharmacology #Precision medicine #Proteomics #Regulatory science #Statistical Methods in Clinical Trials
22. Cancer Chemoprevention: Successes and Failures
    2012/11/13 by Sherri Patterson, Sherri L Patterson, Karen Colbert Maresso +2 · 24 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer #Cancer Research and Treatments #Cancer drugs #Cancer, Lipids, and Metabolism #Clinical trial #Disease #Drug #Drug development #Food and drug administration #Intensive care medicine #Internal medicine #Medicine #Metabolism, Diabetes, and Cancer #Pharmacology
23. Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials
    2012/04/04 by Rupert W. Leong, R Leong, M L T Vieira +9 · 29 citations
    Economics, Econometrics and Finance · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Clinical pharmacology #Clinical trial #Drug #Drug development #Food and drug administration #Internal medicine #Medicine #Pharmaceutical Economics and Policy #Pharmaceutical studies and practices #Pharmacogenetics and Drug Metabolism #Pharmacokinetics #Pharmacology #Physiologically based pharmacokinetic modelling
24. Drug Safety Sciences and the Bottleneck in Drug Development
    2011/05/19 by P B Watkins, PB Watkins · 27 citations
    Economics, Econometrics and Finance · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Business #Clinical trial #Drug #Drug approval #Drug development #Finance #Food and drug administration #Health Systems, Economic Evaluations, Quality of Life #Intensive care medicine #Internal medicine #Liability #Medicine #New drug application #Pharmaceutical Economics and Policy #Pharmacogenetics and Drug Metabolism #Pharmacology #Revenue
25. Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs
    2010/02/03 by Joseph A. DiMasi, J A DiMasi, Laurent J. Feldman +4 · 36 citations
    Business, Management and Accounting · Economics, Econometrics and Finance · Medicine · #Biotechnology and Related Fields #Business #Clinical pharmacology #Clinical trial #Drug #Drug approval #Drug class #Drug development #Intellectual Property and Patents #Internal medicine #Investigational Drugs #Medicine #New drug application #Pharmaceutical Economics and Policy #Pharmacology
26. Therapeutic antibodies: successes, limitations and hopes for the future
    2009/04/28 by Patrick Chames, Marc Van Regenmortel, Étienne Weiss +2 · 32 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Bioinformatics #Biology #Clinical trial #Drug #Drug development #Immune system #Immunology #Intensive care medicine #Medicine #Monoclonal and Polyclonal Antibodies Research #Monoclonal antibody #Pathology #Pharmacology #Protein purification and stability #T-cell and B-cell Immunology
27. Recent Advances in Artemisinin Production Through Heterologous Expression
    2008/10/31 by Patrick R. Arsenault, Kristin K. Wobbe, Pamela J. Weathers · 1 citation
    Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Viral Infectious Diseases and Gene Expression in Insects #Pharmacogenetics and Drug Metabolism #Malaria Research and Control #Artemisinin #Artemisia annua #Metabolic engineering #Plasmodium falciparum #Biology #Biopharmaceutical #Sesquiterpene lactone #Drug discovery #Heterologous #Synthetic biology #Heterologous expression #Drug development #Saccharomyces cerevisiae #Computational biology #Biotechnology #Malaria #Biochemistry #Drug #Gene #Pharmacology #Sesquiterpene #Recombinant DNA
28. Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products
    2008/01/30 by Eugen Koren, Holly W. Smith, Elizabeth Shores +20 · 28 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibody #Biology #Biopharmaceutical #Biosimilars and Bioanalytical Methods #Biotechnology #Clinical trial #Drug #Drug development #Immunogenicity #Immunology #Intensive care medicine #Internal medicine #Licensure #Medicine #Monoclonal and Polyclonal Antibodies Research #Pharmacology #Protein purification and stability
29. Ethnobotany and Ethnopharmacy - Their Role for Anti-Cancer Drug Development
    2006/02/28 by Michael Heinrich, Paul Bremner · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · #Natural product bioactivities and synthesis #Ethnobotany #Convention #Convention on Biological Diversity #Curcumin #Drug development #Traditional medicine #Drug #Medicine #Medicinal plants #Biology #Pharmacology #Ecology #Sociology #Social science #Biodiversity
30. The value of plants used in traditional medicine for drug discovery.
    2001/03/01 by Daniel S. Fabricant, N.R. Farnsworth · 2 citations
    Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Synthesis and bioactivity of alkaloids #Ethnobotanical and Medicinal Plants Studies #Phytochemistry and Bioactivity Studies #Ethnomedicine #Drug discovery #Drug #Traditional medicine #Drug development #Medicine #Computer science #Data science #Medicinal plants #Biology #Pharmacology #Bioinformatics

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