- Gastrointestinal stromal tumour (GIST): British Sarcoma Group clinical practice guidelines
2024/06/05 by Ian Judson, Robin L. Jones, Newton A. C. S. Wong +5 · 25 citations
Medicine · #Clinical Practice #Clinical trial #Etiology #Family medicine #Gastric Cancer Management and Outcomes #Gastrointestinal Tumor Research and Treatment #GiST #Incidence (geometry) #Intensive care medicine #Internal medicine #MEDLINE #Medicine #Pathology #Sarcoma #Sarcoma Diagnosis and Treatment #Stromal cell
- Pimitespib: First Approval
2022/08/20 by Sheridan M. Hoy · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer, Hypoxia, and Metabolism #Chemotherapy #Colorectal Cancer Treatments and Studies #Drug #Drug development #GiST #Heat shock protein #Heat shock proteins research #Hsp90 #Hsp90 inhibitor #Imatinib #Intensive care medicine #Internal medicine #Medicine #Oncology #Pharmacology #Pharmacotherapy #Stromal cell
- Secondary KIT mutations: the GIST of drug resistance and sensitivity
2019/02/22 by Andrea Napolitano, Bruno Vincenzi · 27 citations
Medicine · #Acquired resistance #Bioinformatics #Biology #Cancer #Cancer research #Drug #Drug resistance #Gastric Cancer Management and Outcomes #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #Genetics #GiST #Internal medicine #Medicine #Oncology #Pharmacology #Receptor #Stromal cell #Tyrosine kinase #Tyrosine-kinase inhibitor
- Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib
2017/08/29 by Heikki Joensuu, Jean‐Yves Blay, Jean-Yves Blay +22 · 17 citations
Medicine · #Adverse effect #Chemotherapy #Clinical endpoint #Clinical trial #Dysgeusia #Gastroenterology #Gastrointestinal Bleeding Diagnosis and Treatment #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Imatinib mesylate #Internal medicine #Medicine #Progressive disease #Refractory (planetary science) #Response Evaluation Criteria in Solid Tumors #Stromal cell #Surgery #Tolerability
- Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach
2017/05/23 by Yukinori Kurokawa, Han‐Kwang Yang, Han-Kwang Yang +27 · 25 citations
Medicine · #Breast cancer #Cancer #Chemotherapy #Clinical endpoint #Clinical trial #Gastroenterology #Gastrointestinal Bleeding Diagnosis and Treatment #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Imatinib mesylate #Internal medicine #Medicine #Neoadjuvant therapy #Neutropenia #Stomach #Stromal cell #Surgery #Survival rate
- Definition and clinical significance of tumour rupture in gastrointestinal stromal tumours of the small intestine
2016/03/14 by T Hølmebakk, Toto Hølmebakk, Bodil Bjerkehagen +9 · 25 citations
Medicine · #Ascites #Biopsy #Confidence interval #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Hazard ratio #Internal medicine #Intraperitoneal and Appendiceal Malignancies #Laparotomy #Malignancy #Medicine #Mitotic index #Pathology #Perforation #Peritoneum #Peritonitis #Stromal cell #Surgery
- Esophageal Gastrointestinal Stromal Tumor
2014/01/21 by W. B. Robb, Emilie Bruyère, E. Bruyere +11 · 8 citations
Medicine · #Biopsy #Cancer #Enucleation #Esophageal cancer #Esophagectomy #Esophagus #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Internal medicine #Medicine #Radiology #Stromal cell #Surgery
- Enucleation of Esophageal Submucosal Tumors: A Single Institution's Experience
2013/12/17 by Sumin Shin, Yong Soo Choi, Young Mog Shim +3 · 15 citations
Medicine · #Cancer #Dysphagia #Enucleation #Esophageal Cancer Research and Treatment #Esophageal cancer #Esophagectomy #Esophagus #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Internal medicine #Leiomyoma #Medicine #Retrospective cohort study #Stromal cell #Surgery #Thoracoscopy #Thoracotomy
- Long-term Results of Adjuvant Imatinib Mesylate in Localized, High-Risk, Primary Gastrointestinal Stromal Tumor
2013/07/16 by Ronald P. DeMatteo, Karla V. Ballman, Cristina R. Antonescu +12 · 25 citations
Medicine · #Adjuvant #Adjuvant therapy #Cancer #Clinical endpoint #Clinical trial #Gastroenterology #Gastrointestinal Bleeding Diagnosis and Treatment #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Imatinib mesylate #Internal medicine #Medicine #Metastasis #Oncology #Primary tumor #Stromal cell #Stromal tumor #Surgery
- Vatalanib for metastatic gastrointestinal stromal tumour (GIST) resistant to imatinib: final results of a phase II study
2011/05/01 by H Joensuu, Heikki Joensuu, Filippo de Braud +26 · 15 citations
Medicine · #Cancer #Gastroenterology #Gastrointestinal Bleeding Diagnosis and Treatment #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Imatinib mesylate #Internal medicine #Medicine #Oncology #Pharmacology #Stromal cell #Sunitinib #Tyrosine-kinase inhibitor
- Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour
2010/08/20 by P Hohenberger, Peter Hohenberger, Ulrich Ronellenfitsch +11 · 26 citations
Medicine · #Abdominal cavity #Adjuvant therapy #Chemotherapy #Duodenum #Gastroenterology #Gastrointestinal Bleeding Diagnosis and Treatment #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Internal medicine #Medicine #PDGFRA #Stomach #Stromal cell #Stromal tumor #Surgery
- A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region
2010/06/29 by P A Cassier, Philippe A. Cassier, Françoise Ducimetière +17 · 26 citations
Medicine · #Epidemiology #Gastrointestinal Tumor Research and Treatment #GiST #Imatinib #Incidence (geometry) #Internal medicine #Medicine #Metastasis and carcinoma case studies #Oncology #PDGFRA #Pathology #Prospective cohort study #Sarcoma #Sarcoma Diagnosis and Treatment #Stromal cell #Stromal tumor
- BRAFMutation Status in Gastrointestinal Stromal Tumors
2009/12/19 by Isabelle Hostein, Nicolas Faur, Charlotte Primois +11 · 25 citations
Medicine · #Biology #Cancer research #Gastrointestinal Tumor Research and Treatment #Gene #Genetics #GiST #MAPK/ERK pathway #Medicine #Mutation #Neurofibromatosis and Schwannoma Cases #PDGFRA #Protein kinase B #Proto-Oncogene Proteins c-kit #Sarcoma Diagnosis and Treatment #Signal transduction #Stromal cell #Stromal tumor #V600E
- Surgical Considerations for the Management and Resection of Esophageal Gastrointestinal Stromal Tumors
2007/11/01 by Matthew G. Blum, Karl Y. Bilimoria, Jeffrey D. Wayne +4 · 18 citations
Medicine · #CD117 #CD34 #Cancer #Enucleation #Esophageal cancer #Esophagectomy #Esophagus #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Internal medicine #Leiomyoma #Leiomyosarcoma #Medicine #Pathology #Sarcoma #Sarcoma Diagnosis and Treatment #Stromal cell #Submucosa #Sunitinib #Surgery
- Hypothyroidism after Sunitinib Treatment for Patients with Gastrointestinal Stromal Tumors
2006/11/07 by Jayesh Desai, Leila Yassa, Ellen Marqusee +8 · 26 citations
Medicine · #Cancer #Gastrointestinal Tumor Research and Treatment #GiST #Internal medicine #Medicine #Neuroendocrine Tumor Research Advances #Oncology #Renal cell carcinoma treatment #Stromal cell #Sunitinib
- Combined Surgical and Molecular Therapy
2006/07/19 by Jason S. Gold, Ronald P. DeMatteo · 25 citations
Medicine · #Adjuvant therapy #Cancer #Cancer research #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Imatinib #Imatinib mesylate #Immunohistochemistry #Internal medicine #Interstitial cell of Cajal #Medicine #Oncology #PDGFRA #Pathology #Stromal cell #Stromal tumor #Sunitinib #Targeted therapy #Teratomas and Epidermoid Cysts #Tyrosine kinase #Tyrosine-kinase inhibitor
- Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
2006/03/28 by N Théou-Anton, Nathalie Théou–Anton, S Tabone +10 · 11 citations
Medicine · #Autocrine signalling #Biology #Cancer research #Cell biology #Cell culture #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #Genetics #GiST #Immunohistochemistry #Immunology #Interstitial cell of Cajal #Medicine #Paracrine signalling #Pathology #Proto-Oncogene Proteins c-kit #Receptor #Receptor tyrosine kinase #Sarcoma Diagnosis and Treatment #Stem cell #Stem cell factor #Stromal cell #Tyrosine kinase
- Gastrointestinal stromal tumors in Iceland, 1990–2003: The Icelandic GIST study, a population‐based incidence and pathologic risk stratification study
2005/05/17 by Geir Tryggvason, Hjörtur Gíslason, Hjörtur G. Gíslason +2 · 27 citations
Medicine · #Gastric Cancer Management and Outcomes #Gastroenterology #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Incidence (geometry) #Internal medicine #Medicine #Oncology #Pathology #Population #Stromal cell #Stromal tumor
- Protein Kinase C θ (PKCθ) Expression and Constitutive Activation in Gastrointestinal Stromal Tumors (GISTs)
2004/08/01 by Anette Duensing, Nora Joseph, Nora E. Joseph +11 · 19 citations
Medicine · #Biology #Cancer #Cancer research #Cell biology #Chronic Myeloid Leukemia Treatments #Gastrointestinal Tumor Research and Treatment #GiST #Imatinib #Imatinib mesylate #Immunohistochemistry #Internal medicine #Kinase #Medicine #PDGFRA #Pathology #Platelet Disorders and Treatments #Protein kinase C #Proto-Oncogene Proteins c-kit #Receptor #Receptor tyrosine kinase #Stem cell factor #Stromal cell #Tyrosine kinase #Tyrosine-kinase inhibitor
- The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status
2004/07/01 by Robert B. West, Christopher L. Corless, Xin Chen +12 · 28 citations
Medicine · #Biology #Cancer research #Gastrointestinal Tumor Research and Treatment #Gene #Genetics #GiST #Medicine #Metastasis and carcinoma case studies #Mutation #PDGFRA #Pathology #Proto-Oncogene Proteins c-kit #Sarcoma Diagnosis and Treatment #Stromal cell
- Two Hundred Gastrointestinal Stromal Tumors
2000/01/01 by Ronald P. DeMatteo, Jonathan J. Lewis, Denis H. Y. Leung +5 · 29 citations
Medicine · #Adjuvant therapy #Cancer #Chemotherapy #Disease #Gastrointestinal Tumor Research and Treatment #Gastrointestinal disorders and treatments #GiST #Internal medicine #Medicine #Metastasis #Minimally Invasive Surgical Techniques #Pathology #Primary tumor #Sarcoma #Stromal cell #Stromal tumor #Surgery #Survival rate
- Mutations in Exon 11 of c-Kit Occur Preferentially in Malignant versus Benign Gastrointestinal Stromal Tumors and Do Not Occur in Leiomyomas or Leiomyosarcomas
1999/01/01 by Jerzy Lasota, Marek Jasiński, Marek Jasinski +3 · 30 citations
Immunology and Microbiology · Medicine · #Biology #CD117 #CD34 #Cancer research #Exon #Gastrointestinal Tumor Research and Treatment #Gastrointestinal tract #Gene #Genetics #Germline mutation #GiST #Immunohistochemistry #Leiomyoma #Leiomyosarcoma #Mast cells and histamine #Medicine #Mutation #Pathology #Platelet Disorders and Treatments #Point mutation #Smooth Muscle Tumor #Stromal cell #Stromal tumor